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Detection Of Celiac Disease Using A Deep Learning Algorithm

  • Aims Celiac disease (CD) is a complex condition caused by an autoimmune reaction to ingested gluten. Due to its polymorphic manifestation and subtle endoscopic presentation, the diagnosis is difficult and thus the disorder is underreported. We aimed to use deep learning to identify celiac disease on endoscopic images of the small bowel. Methods Patients with small intestinal histology compatible with CD (MARSH classification I-III) were extracted retrospectively from the database of Augsburg University hospital. They were compared to patients with no clinical signs of CD and histologically normal small intestinal mucosa. In a first step MARSH III and normal small intestinal mucosa were differentiated with the help of a deep learning algorithm. For this, the endoscopic white light images were divided into five equal-sized subsets. We avoided splitting the images of one patient into several subsets. A ResNet-50 model was trained with the images from four subsets and then validated with the remaining subset. This process was repeated for each subset, such that each subset was validated once. Sensitivity, specificity, and harmonic mean (F1) of the algorithm were determined. Results The algorithm showed values of 0.83, 0.88, and 0.84 for sensitivity, specificity, and F1, respectively. Further data showing a comparison between the detection rate of the AI model and that of experienced endoscopists will be available at the time of the upcoming conference. Conclusions We present the first clinical report on the use of a deep learning algorithm for the detection of celiac disease using endoscopic images. Further evaluation on an external data set, as well as in the detection of CD in real-time, will follow. However, this work at least suggests that AI can assist endoscopists in the endoscopic diagnosis of CD, and ultimately may be able to do a true optical biopsy in live-time.

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Verfasserangaben:Markus W. ScheppachORCiD, David Rauber, Robert MendelORCiD, Christoph PalmORCiDGND, Michael F. Byrne, Helmut Messmann, Alanna EbigboORCiD
DOI:https://doi.org/10.1055/s-0041-1724970
Titel des übergeordneten Werkes (Englisch):Endoscopy
Verlag:Georg Thieme Verlag
Verlagsort:Stuttgart
Dokumentart:Konferenzveröffentlichung (Präsentation, Abstract)
Sprache der Veröffentlichung:Englisch
Jahr der Veröffentlichung:2021
Datum der Freischaltung:30.07.2021
Freies Schlagwort / Tag:Celiac Disease; Deep Learning
Jahrgang:53
Ausgabe / Heft:S 01
Aufsatznummer:S256
Bemerkung:
Digital poster exhibition
Konferenzangabe:ESGE Days 2021
Fakultäten / Institute / Einrichtungen:Fakultät Informatik und Mathematik
Regensburg Center of Health Sciences and Technology - RCHST
Fakultät Informatik und Mathematik / Regensburg Medical Image Computing (ReMIC)
Begutachtungsstatus:peer-reviewed
Forschungsschwerpunkt:Lebenswissenschaften und Ethik
Lizenz (Deutsch):Keine Lizenz - Es gilt das deutsche Urheberrecht: § 53 UrhG