AI-assisted detection and characterization of early Barrett's neoplasia: Results of an Interim analysis

  • Aims  Evaluation of the add-on effect an artificial intelligence (AI) based clinical decision support system has on the performance of endoscopists with different degrees of expertise in the field of Barrett's esophagus (BE) and Barrett's esophagus-related neoplasia (BERN). Methods  The support system is based on a multi-task deep learning model trained to solve a segmentation and several classification tasks. The training approach represents an extension of the ECMT semi-supervised learning algorithm. The complete system evaluates a decision tree between estimated motion, classification, segmentation, and temporal constraints, to decide when and how the prediction is highlighted to the observer. In our current study, ninety-six video cases of patients with BE and BERN were prospectively collected and assessed by Barrett's specialists and non-specialists. All video cases were evaluated twice – with and without AI assistance. The order of appearance, either with or without AI support, was assigned randomly. Participants were asked to detect and characterize regions of dysplasia or early neoplasia within the video sequences. Results  Standalone sensitivity, specificity, and accuracy of the AI system were 92.16%, 68.89%, and 81.25%, respectively. Mean sensitivity, specificity, and accuracy of expert endoscopists without AI support were 83,33%, 58,20%, and 71,48 %, respectively. Gastroenterologists without Barrett's expertise but with AI support had a comparable performance with a mean sensitivity, specificity, and accuracy of 76,63%, 65,35%, and 71,36%, respectively. Conclusions  Non-Barrett's experts with AI support had a similar performance as experts in a video-based study.

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Author:Michael Meinikheim, Robert MendelORCiD, Andreas Probst, Markus W. ScheppachORCiD, Elisabeth Schnoy, Sandra Nagl, Christoph Römmele, Friederike Prinz, Jakob Schlottmann, Daniela Golger, Christoph PalmORCiDGND, Helmut Messmann, Alanna EbigboORCiD
DOI:https://doi.org/10.1055/s-0043-1765437
Parent Title (English):Endoscopy
Publisher:Thieme
Document Type:conference proceeding (presentation, abstract)
Language:English
Year of first Publication:2023
Release Date:2023/05/08
Volume:55
Issue:S02
Pagenumber:S169
Konferenzangabe:ESGE Days 2023
Institutes:Fakultät Informatik und Mathematik
Regensburg Center of Health Sciences and Technology - RCHST
Fakultät Informatik und Mathematik / Regensburg Medical Image Computing (ReMIC)
Begutachtungsstatus:peer-reviewed
research focus:Lebenswissenschaften und Ethik
Licence (German):Keine Lizenz - Es gilt das deutsche Urheberrecht: § 53 UrhG