Design and validation of an additively manufactured flowCell–static mixer combination for inline NMR spectroscopy
- There have been an increasing number of publications on flow chemistry applications of compact NMR. Despite this, there is so far no comprehensive workflow for the technical design of flow cells. Here, we present an approach that is suitable for the design of an NMR flow cell with an integrated static mixing unit. This design moves the mixing of reactants to the active NMR detection region within the NMR instrument, presenting a feature that analyses chemical reactions faster (5–120 s region) than other common setups. During the design phase, the targeted mixing homogeneity of the components was evaluated for different types of mixing units based on CFD simulation. Subsequently, the flow cell was additively manufactured from ceramic material and metal tubing. Within the targeted working mass flow range, excellent mixing properties as well as narrow line widths were confirmed in validation experiments, comparable to common glassThere have been an increasing number of publications on flow chemistry applications of compact NMR. Despite this, there is so far no comprehensive workflow for the technical design of flow cells. Here, we present an approach that is suitable for the design of an NMR flow cell with an integrated static mixing unit. This design moves the mixing of reactants to the active NMR detection region within the NMR instrument, presenting a feature that analyses chemical reactions faster (5–120 s region) than other common setups. During the design phase, the targeted mixing homogeneity of the components was evaluated for different types of mixing units based on CFD simulation. Subsequently, the flow cell was additively manufactured from ceramic material and metal tubing. Within the targeted working mass flow range, excellent mixing properties as well as narrow line widths were confirmed in validation experiments, comparable to common glass tubes.…
Autor*innen: | Martin Bornemann-PfeifferORCiD, Simon KernORCiD, N. Jurtz, Tobias Thiede, M. Kraume, Michael MaiwaldORCiD |
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Dokumenttyp: | Zeitschriftenartikel |
Veröffentlichungsform: | Verlagsliteratur |
Sprache: | Englisch |
Titel des übergeordneten Werkes (Englisch): | Industrial & Engineering Chemistry Research |
Jahr der Erstveröffentlichung: | 2019 |
Organisationseinheit der BAM: | 1 Analytische Chemie; Referenzmaterialien |
1 Analytische Chemie; Referenzmaterialien / 1.4 Prozessanalytik | |
8 Zerstörungsfreie Prüfung | |
8 Zerstörungsfreie Prüfung / 8.5 Röntgenbildgebung | |
Verlag: | American Chemical Society |
Verlagsort: | Washington |
Jahrgang/Band: | 58 |
Ausgabe/Heft: | 42 |
Erste Seite: | 19562 |
Letzte Seite: | 19570 |
DDC-Klassifikation: | Naturwissenschaften und Mathematik / Chemie / Analytische Chemie |
Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Ingenieurwissenschaften und zugeordnete Tätigkeiten | |
Freie Schlagwörter: | Flow Chemistry; Inline NMR Spectroscopy; Integrated Processes; Modular Production; Process Analytical Technology; Reaction Monitoring; Static Mixing |
Themenfelder/Aktivitätsfelder der BAM: | Chemie und Prozesstechnik |
Chemie und Prozesstechnik / Chemische Charakterisierung und Spurenanalytik | |
Material | |
Umwelt | |
Umwelt / Sensorik | |
DOI: | 10.1021/acs.iecr.9b03746 |
URL: | https://pubs.acs.org/doi/abs/10.1021/acs.iecr.9b03746 |
ISSN: | 0888-5885 |
ISSN: | 1520-5045 |
Bemerkung: | Geburtsname von Bornemann-Pfeiffer, Martin: Bornemann, M. - Birth name of Bornemann-Pfeiffer, Martin: Bornemann, M. |
Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
Datum der Freischaltung: | 23.09.2019 |
Referierte Publikation: | Ja |
Datum der Eintragung als referierte Publikation: | 18.12.2019 |