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Simple and versatile methods for quantifying functional groups, ligands, and biomolecules on nanomaterials

  • Many applications of nanomaterials in the life sciences require the controlled functionalization of these materials with ligands like polyethylene glycol (PEG) and/or biomolecules such as peptides, proteins, and DNA. This enables to tune their hydrophilicity and biocompatibility, minimize unspecific interactions, improve biofunction-nalization efficiencies, and enhance blood circulation times and is the ultimate prerequisite for their use as reporters in assays or the design of targeted optial probes for bioimaging. At the core of these functionalization strategies are reliable and validated methods for surface group and ligand quantification that can be preferably performed with routine laboratory instrumentation, require only small amounts of substances, and are suitable for many different types of nanomaterials. We present here versatile and simple concepts for the quantification of common functional groups, ligands, and biomolecules on different types of organic and inorganicMany applications of nanomaterials in the life sciences require the controlled functionalization of these materials with ligands like polyethylene glycol (PEG) and/or biomolecules such as peptides, proteins, and DNA. This enables to tune their hydrophilicity and biocompatibility, minimize unspecific interactions, improve biofunction-nalization efficiencies, and enhance blood circulation times and is the ultimate prerequisite for their use as reporters in assays or the design of targeted optial probes for bioimaging. At the core of these functionalization strategies are reliable and validated methods for surface group and ligand quantification that can be preferably performed with routine laboratory instrumentation, require only small amounts of substances, and are suitable for many different types of nanomaterials. We present here versatile and simple concepts for the quantification of common functional groups, ligands, and biomolecules on different types of organic and inorganic nano-materials, using different types of optical reporters and method validation with the aid of multimodal reporters and mass balances.zeige mehrzeige weniger

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Metadaten
Autor*innen:Ute Resch-GengerORCiD
Koautor*innen:Nithiya Nirmalananthan-Budau, Marko Moser, Daniel Geißsler, Thomas Behnke, Ralf Schneider
Dokumenttyp:Vortrag
Veröffentlichungsform:Präsentation
Sprache:Englisch
Jahr der Erstveröffentlichung:2018
Organisationseinheit der BAM:1 Analytische Chemie; Referenzmaterialien
1 Analytische Chemie; Referenzmaterialien / 1.2 Biophotonik
DDC-Klassifikation:Naturwissenschaften und Mathematik / Chemie / Analytische Chemie
Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Ingenieurwissenschaften und zugeordnete Tätigkeiten
Freie Schlagwörter:Absolute fluorescence quantum yield; Fluorescence decay kinetics; Integrating sphere spectroscopy; PEG ligands; Surface group analysis; Upconverting nanoparticles
Themenfelder/Aktivitätsfelder der BAM:Chemie und Prozesstechnik
Material
Material / Degradation von Werkstoffen
Umwelt
Umwelt / Sensorik
Veranstaltung:RSC Symposium on Nanoparticle concentration – critical needs and state-of-the-art measurement
Veranstaltungsort:London, UK
Beginndatum der Veranstaltung:24.04.2018
Enddatum der Veranstaltung:25.04.2018
Bemerkung:
Geburtsname von Nirmalananthan-Budau, Nithiya: Nirmalananthan, N. -  Birth name of Nirmalananthan-Budau, Nithiya: Nirmalananthan, N.
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:23.05.2018
Referierte Publikation:Nein
Eingeladener Vortrag:Nein
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