Combination of Monte-Carlo simulations and experimental results to determine the microscopic energy depoit at DNA
- The quantification of radiation induced damage to DNA in aqueous en- vironment is of fundamental interest for dosimetry and its application in radiation-therapy and protection. We present a combined experi- mental and simulational approach to quantify and compare radiation induced damage to biomolecules in liquid environment for a wide range of primary radiation sources e. g. photons, electrons or ions and tar- gets, such as DNA, proteins or cells.[1] To show its viability, we will apply this method to an experimentally challenging systems, the di- rect irradiation of plasmid DNA (pUC19) in water with electrons as primary particles. Here we combine Geant4 electron-scattering simula- tions with calculations concerning the diffusion and convection induced movement of the biomolecules, within a coarse-grained model of the irradiated liquid. Additionally a microscopic target model for the plas- mid DNA based on the relation of lineal energy and radiation quality is used toThe quantification of radiation induced damage to DNA in aqueous en- vironment is of fundamental interest for dosimetry and its application in radiation-therapy and protection. We present a combined experi- mental and simulational approach to quantify and compare radiation induced damage to biomolecules in liquid environment for a wide range of primary radiation sources e. g. photons, electrons or ions and tar- gets, such as DNA, proteins or cells.[1] To show its viability, we will apply this method to an experimentally challenging systems, the di- rect irradiation of plasmid DNA (pUC19) in water with electrons as primary particles. Here we combine Geant4 electron-scattering simula- tions with calculations concerning the diffusion and convection induced movement of the biomolecules, within a coarse-grained model of the irradiated liquid. Additionally a microscopic target model for the plas- mid DNA based on the relation of lineal energy and radiation quality is used to calculate the effective target volume.…
Autor*innen: | Marc Benjamin HahnORCiD |
---|---|
Koautor*innen: | Tihomir Solomun, Heinz SturmORCiD |
Dokumenttyp: | Posterpräsentation |
Veröffentlichungsform: | Präsentation |
Sprache: | Englisch |
Jahr der Erstveröffentlichung: | 2018 |
Organisationseinheit der BAM: | 6 Materialchemie |
6 Materialchemie / 6.6 Physik und chemische Analytik der Polymere | |
DDC-Klassifikation: | Naturwissenschaften und Mathematik / Chemie / Analytische Chemie |
Freie Schlagwörter: | DNA; DNA damage; DNA radiation damage; Dosimetry; Electron scattering; Geant4; Hydroxyl radicals; Low energy electrons; Microdosimetry; Monte-Carlo simulation; Radiation damage; Target volume |
Themenfelder/Aktivitätsfelder der BAM: | Chemie und Prozesstechnik |
Veranstaltung: | DPG-Frühjahrstagung der Sektion Kondensierte Materie gemeinsam mit der EPS |
Veranstaltungsort: | Berlin, Germany |
Beginndatum der Veranstaltung: | 11.03.2018 |
Enddatum der Veranstaltung: | 16.03.2018 |
Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
Datum der Freischaltung: | 27.03.2018 |
Referierte Publikation: | Nein |