Guided crystallization: The influence of solvent and concentration
- Theoretical and experimental studies indicate that crystal nucleation can take more complex pathways than expected on the ground of the classical nucleation theory. A direct in situ observation of the different pathways of nucleation from solution is challenging since the paths can be influenced by heterogeneous nucleation sites, such as container walls. The custom-made acoustic levitator using in these experiments regulates the influence that solid surfaces, temperature, and humidity have on the crystallization process. The investigations of the crystallization process of paracetamol were performed with in situ analytical techniques and theoretical simulations to gain a comprehensive insight into processes, occurring intermediates, and required reaction conditions. The targeted choice of the solvent and the concentration enabled the guidance of the pathways, therefore, resulting in the isolation of one desired crystalline structure.
Autor*innen: | Thi Yen Nguyen |
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Koautor*innen: | C. E. S. Bernardes, M. E. Minas da Piedade, K. Rademann, Franziska EmmerlingORCiD |
Dokumenttyp: | Posterpräsentation |
Veröffentlichungsform: | Präsentation |
Sprache: | Englisch |
Jahr der Erstveröffentlichung: | 2017 |
DDC-Klassifikation: | Naturwissenschaften und Mathematik / Chemie / Analytische Chemie |
Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Ingenieurwissenschaften und zugeordnete Tätigkeiten | |
Freie Schlagwörter: | Crystallization; Molecular dynamic simulation; Pair distribution function analysis; Polymorphism; XRD |
Veranstaltung: | Annual COST meeting |
Veranstaltungsort: | Lincoln, United Kingdom |
Beginndatum der Veranstaltung: | 25.06.2017 |
Enddatum der Veranstaltung: | 27.06.2017 |
Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
Datum der Freischaltung: | 25.07.2017 |
Referierte Publikation: | Nein |