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Separation and surface groups quantification of polystyrene nanoparticles using capillary electrophoresis (CE) and asymmetrcal flow-field-flow fractionation (AF4)

  • Nowadays, different nanoparticles have been developed for commercial applications. However, since data on toxicity are barely available, their increasing application in cosmetic products, food and their release in the environment might cause severe problems. Since a range of physical, chemical, and biological characteristics of NPs are closely related to particle size and surface functionalization, precise separation and surface groups quantification is essential to acquire an in-depth understanding of their properties. In this work, the performance of asymmetrical flow field flow fractionation (AF4) and capillary electrophoresis (CE) for the separation of nanoparticles (NPs) with different sizes, coatings, and coating densities was investigated and optimized. For the first time, a two-dimensional off-line hyphenation of both techniques (AF4-CE) was developed. The results clearly demonstrated, that AF4-CE hyphenation can significantly improve the separation resolution and reduce theNowadays, different nanoparticles have been developed for commercial applications. However, since data on toxicity are barely available, their increasing application in cosmetic products, food and their release in the environment might cause severe problems. Since a range of physical, chemical, and biological characteristics of NPs are closely related to particle size and surface functionalization, precise separation and surface groups quantification is essential to acquire an in-depth understanding of their properties. In this work, the performance of asymmetrical flow field flow fractionation (AF4) and capillary electrophoresis (CE) for the separation of nanoparticles (NPs) with different sizes, coatings, and coating densities was investigated and optimized. For the first time, a two-dimensional off-line hyphenation of both techniques (AF4-CE) was developed. The results clearly demonstrated, that AF4-CE hyphenation can significantly improve the separation resolution and reduce the peak broadening in CE. Also, for the first time, CE was employed to determine the coating density of NPs and the results were in good agreement with the values acquired with conductometric titration.zeige mehrzeige weniger

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Metadaten
Autor*innen:Zengchao You
Dokumenttyp:Vortrag
Veröffentlichungsform:Präsentation
Sprache:Englisch
Jahr der Erstveröffentlichung:2019
Organisationseinheit der BAM:6 Materialchemie
6 Materialchemie / 6.3 Strukturanalytik
DDC-Klassifikation:Naturwissenschaften und Mathematik / Chemie / Analytische Chemie
Freie Schlagwörter:Capillary electrophoresis; Nanoparticle
Themenfelder/Aktivitätsfelder der BAM:Chemie und Prozesstechnik
Veranstaltung:2nd CE Forum
Veranstaltungsort:Karlsruhe, Germany
Beginndatum der Veranstaltung:11.12.2019
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:16.12.2019
Referierte Publikation:Nein
Eingeladener Vortrag:Nein
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