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Experimentally validated simulation of coronary stents considering different dogboning ratios and asymmetric stent positioning

  • In-stent restenosis remains a major problem of arteriosclerosis treatment by stenting. Expansion-optimized stents could reduce this problem. With numerical simulations, stent designs/ expansion behaviours can be effectively analyzed. For reasons of efficiency, simplified models of balloon-expandable stents are often used, but their accuracy must be challenged due to insufficient experimental validation. In this work, a realistic stent life-cycle simulation has been performed including balloon folding, stent crimping and free expansion of the balloon-stent-system. The successful simulation and validation of two stent designs with homogenous and heterogeneous stent stiffness and an asymmetrically positioned stent on the balloon catheter confirm the universal applicability of the simulation approach. Dogboning ratio, as well as the final dimensions of the folded balloon, the crimped and expanded stent, correspond well to the experimental dimensions with only slight deviations. In contrast to the detailed stent life-cycle simulation, a displacement-controlled simulation can not predict the transient stent expansion, but is suitable to reproduce the final expanded stent shape and the associated stress states. The detailed stent life-cycle simulation is thus essential for stent expansion analysis/optimization, whereas for reasons of computational efficiency, the displacement-controlled approach can be considered in the context of pure stress analysis.

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Metadaten
Verfasserangaben:Lisa WiesentORCiD, Ulrich Schultheiss, Christof Schmid, Thomas SchratzenstallerORCiD, Aida NonnORCiDGND
DOI:https://doi.org/10.1371/journal.pone.0224026
Titel des übergeordneten Werkes (Englisch):PlOS One
Verlag:PLOS
Dokumentart:Artikel aus einer Zeitschrift/Zeitung
Sprache der Veröffentlichung:Englisch
Jahr der Veröffentlichung:2019
Datum der Freischaltung:12.05.2020
Freies Schlagwort / Tag:Catheters; Coronary stenting; Deformation; Stent implantation; Stiffness
GND-Schlagwort:Stent; Ballondilatation; Numerische Strömungssimulation
Jahrgang:14
Ausgabe / Heft:10
Aufsatznummer:e0224026
Erste Seite:1
Letzte Seite:25
Fakultäten / Institute / Einrichtungen:Fakultät Maschinenbau
Regensburg Center of Biomedical Engineering - RCBE
Fakultät Maschinenbau / Labor Medizinprodukte
Fakultät Maschinenbau / Computational Mechanics and Materials Lab (CMM)
Begutachtungsstatus:peer-reviewed
OpenAccess Publikationsweg:Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium
Forschungsschwerpunkt:Lebenswissenschaften und Ethik
Lizenz (Deutsch):Creative Commons - CC BY - Namensnennung 4.0 International