Polymorphism in Simvastatin: A Single Crystal X-ray Diffraction, Themodynamic, and MDSimulation Study
- Simvastatin is a prominent member of the statin family, a class of antilipidemic drugs widely used in the treatment of high plasma cholesterol levels, and thus in the prevention of atherosclerosis and cardiovascular diseases. Simvastatin is typically employed as a solid and it is well known that, in this case, the detection and characterization of polymorphism is of considerable importance. Polymorphs differ by their packing arrangements and also, occasionally, by the conformations of the molecules in the crystal lattice. These structural variations are normally reflected by differences in physical properties, such as solubility and dissolution rate in a given media, which may significantly affect the bioavailability of a drug. The lack of control of polymorphism can, therefore, play havoc with the safe use of a drug.
Autor*innen: | F. M. Piedada |
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Koautor*innen: | R. G. Simöes, C.E.S. Bernardes, A. Joseph, Werner Kraus, H. Diogo, Franziska EmmerlingORCiD, M. E. M. da Piedada |
Dokumenttyp: | Posterpräsentation |
Veröffentlichungsform: | Präsentation |
Sprache: | Englisch |
Jahr der Erstveröffentlichung: | 2017 |
DDC-Klassifikation: | Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Ingenieurwissenschaften und zugeordnete Tätigkeiten |
Freie Schlagwörter: | Polymorphism; X-ry Diffraction |
Veranstaltung: | COST Action CM1402 |
Veranstaltungsort: | Lincoln, United Kingdom |
Beginndatum der Veranstaltung: | 26.06.2017 |
Enddatum der Veranstaltung: | 26.06.2017 |
Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
Datum der Freischaltung: | 09.08.2017 |
Referierte Publikation: | Nein |