• Treffer 39 von 193
Zurück zur Trefferliste

Detection of aluminum nanoparticles in biological media and in vitro

  • Aluminum is the third most abundant element in the earth crust and therefore ubiquitously detectable in the environment. Mostly found in the form of derivatives such as silicates or oxides, it also occurs as metallic aluminum for example as colorant in sweets or in aluminum foil. With regard to potential toxicological effects, the different solubility of metallic aluminum nanoparticles compared to Al2O3 is of high relevance. Formation of ions may facilitate the crossing of blood-tissue barriers. Distribution towards other organs and subsequent re-formation of particulate aluminum due to milieu changes might occur. Therefore, the determination of solubility is required for proper risk assessment. Inductively coupled plasma mass spectrometry (ICP-MS) allows determination of aluminum with a detection limit of about 6 ppb. It could be proven that dissolution and solubility of metallic aluminum is significantly different when compared to Al2O3. Using ICP-MS in the single particle mode,Aluminum is the third most abundant element in the earth crust and therefore ubiquitously detectable in the environment. Mostly found in the form of derivatives such as silicates or oxides, it also occurs as metallic aluminum for example as colorant in sweets or in aluminum foil. With regard to potential toxicological effects, the different solubility of metallic aluminum nanoparticles compared to Al2O3 is of high relevance. Formation of ions may facilitate the crossing of blood-tissue barriers. Distribution towards other organs and subsequent re-formation of particulate aluminum due to milieu changes might occur. Therefore, the determination of solubility is required for proper risk assessment. Inductively coupled plasma mass spectrometry (ICP-MS) allows determination of aluminum with a detection limit of about 6 ppb. It could be proven that dissolution and solubility of metallic aluminum is significantly different when compared to Al2O3. Using ICP-MS in the single particle mode, a significant change in the behavior of both aluminum species was detected after undergoing the artificial digestion. Nearly unchanged in the saliva, particles show dissolution and high agglomeration during the gastric state before deagglomerating again in the intestine. Further analysis by time-of-flight secondary ion mass spectrometry (ToF-SIMS) revealed the uptake of both aluminum forms by proliferating and differentiated Caco-2 cells. For both particle forms different ions could be detected. Several aluminum-amino acid complex-derived ions from serine and valine were identified. In the case of Al2O3, Al2O2+, AlOH+, AlH2O+ and Al[(H2O)6]3+ were the main ions found co-localizing within treated cells.zeige mehrzeige weniger

Volltext Dateien herunterladen

  • Poster_EWCPS_2017.pdf
    eng

Metadaten exportieren

Weitere Dienste

Teilen auf Twitter Suche bei Google Scholar Anzahl der Zugriffe auf dieses Dokument
Metadaten
Autor*innen:B. Krause
Koautor*innen:H. Sieg, Claudia Kästner, T. Meyer, P. Reichardt, D. Lichtenstein, A. Burel, L. Boehmert, H. Jungnickel, J. Tentschert, P. Laux, A. Braeuning, I. Estrela-Lopis, F. Gauffre, V. Fessard, Andreas Thuenemann, A. Lampen, A. Luch
Dokumenttyp:Posterpräsentation
Veröffentlichungsform:Präsentation
Sprache:Englisch
Jahr der Erstveröffentlichung:2017
DDC-Klassifikation:Naturwissenschaften und Mathematik / Chemie / Analytische Chemie
Freie Schlagwörter:Aluminum; Artificial digestion; Cellular uptake; SAXS; SP-ICP-MS
Veranstaltung:European Winter Conference for Plasma Spectrochemistry 2017
Veranstaltungsort:Sankt Anton, Austria
Beginndatum der Veranstaltung:19.02.2017
Enddatum der Veranstaltung:24.02.2017
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:20.02.2017
Referierte Publikation:Nein
Einverstanden
Diese Webseite verwendet technisch erforderliche Session-Cookies. Durch die weitere Nutzung der Webseite stimmen Sie diesem zu. Unsere Datenschutzerklärung finden Sie hier.