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How hydrodynamic fractionation influences MPI performance of resovist

  • We studied the magnetic resonance imaging liver contrast agent Resovist by a variety of magnetic measurement techniques, in order to understand the physical mechanism of their high magnetic particle imaging (MPI) performance, wirh a focus on the size-dependent contributions of the MPI signal. To this end, we used asymmetric flow field-flow fractionation to separate Resovist into a set of fractions with defined hydrodynamic diameters. The individual fractions were magnetically characterized by static magnetization and magnetorelaxometry measurements to obtain the corresponding effective magnetic anisotropy and effective size distribution parameters. In addition, the MPI performance of each fraction was assessed by magnetic particle spectroscopy. We observed an MPI signal gain of about 100% with respect to their iron amount for the best fraction. Relating these finding to the results from magnetic characterization provides more insight into mechanisms of MPI performance of Resovist. ThisWe studied the magnetic resonance imaging liver contrast agent Resovist by a variety of magnetic measurement techniques, in order to understand the physical mechanism of their high magnetic particle imaging (MPI) performance, wirh a focus on the size-dependent contributions of the MPI signal. To this end, we used asymmetric flow field-flow fractionation to separate Resovist into a set of fractions with defined hydrodynamic diameters. The individual fractions were magnetically characterized by static magnetization and magnetorelaxometry measurements to obtain the corresponding effective magnetic anisotropy and effective size distribution parameters. In addition, the MPI performance of each fraction was assessed by magnetic particle spectroscopy. We observed an MPI signal gain of about 100% with respect to their iron amount for the best fraction. Relating these finding to the results from magnetic characterization provides more insight into mechanisms of MPI performance of Resovist. This knowledge may help to improve the design of novel MPI tracers.zeige mehrzeige weniger

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Metadaten
Autor*innen:N. Löwa, Patrick Knappe, F. Wiekhorst, D. Eberbeck, Andreas ThünemannORCiD, L. Trahms
Dokumenttyp:Zeitschriftenartikel
Veröffentlichungsform:Verlagsliteratur
Sprache:Englisch
Titel des übergeordneten Werkes (Englisch):IEEE transactions on magnetics
Jahr der Erstveröffentlichung:2015
Herausgeber (Institution):Magnetics Society
Verlag:Institute of Electrical and Electronics Engineers
Verlagsort:New York, NY
Jahrgang/Band:51
Ausgabe/Heft:2
Erste Seite:5300104-1
Letzte Seite:5300104-4
Freie Schlagwörter:Asymmetric flow field-flow fractionation; Magnetic nanoparticles (MNP); Magnetic particle imaging (MPI); Magnetic particle spectroscopy; Magnetic separation; Magnetorelaxometry (MRX); Nanoparticles; Nanotechnology; Resovist
DOI:10.1109/TMAG.2014.2326833
ISSN:0018-9464
ISSN:1941-0069
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:20.02.2016
Referierte Publikation:Ja
Datum der Eintragung als referierte Publikation:04.06.2015
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