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Many different cell types are able to migrate by formation of a thin actin-based cytoskeletal extension. Recently, it became evident that this extension consists of two distinct substructures, designated lamellipodium and lamellum, which differ significantly in their kinetic and kinematic properties as well as their biochemical composition. We developed a stochastic two-dimensional computer simulation that includes chemical reaction kinetics, G-actin diffusion, and filament transport to investigate the formation of growing actin networks in migrating cells. Model parameters were chosen based on experimental data or theoretical considerations. In this work, we demonstrate the system's ability to form two distinct networks by self-organization. We found a characteristic transition in mean filament length as well as a distinct maximum in depolymerization flux, both within the first 1-2 microm. The separation into two distinct substructures was found to be extremely robust with respect to initial conditions and variation of model parameters. We quantitatively investigated the complex interplay between ADF/cofilin and tropomyosin and propose a plausible mechanism that leads to spatial separation of, respectively, ADF/cofilin- or tropomyosin-dominated compartments. Tropomyosin was found to play an important role in stabilizing the lamellar actin network. Furthermore, the influence of filament severing and annealing on the network properties is explored, and simulation data are compared to existing experimental data.
Increasing global awareness of the benefits of electromobility has brought about the need for new concepts in terms of the acoustic design of future vehicle generations. This includes both the creative design process and the development of suitable methods for the evaluation of target sounds by trial participants. The main difference between e-car sound surveys and those carried out on familiar sound categories is the potential consumer’s lack of experience with electric vehicles. Thus the consumer has no, or very unspecific, expectations in this regard. Several studies have consequently shown that many subjects have to construct their personal frame of reference for evaluation within the listening experiment. However, this is possibly at odds with experience-based expectations relating to the sounds of conventional combustion engines. The result is a conflict of objectives between the traditional and the modern, familiarity and strangeness and not least between driving freedom and ecological awareness. In this context, the authenticity of the sound and the subjective interpretability of the sound information also appear as moderator variables. Moreover, associations with other vehicle categories, for example streetcars, also influence the perceived sound quality. In the course of this contribution, these factors will be expounded and their influence on the evaluation of interior noise discussed.