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- Rammed earth (3)
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Supplementary comparison study - measurement capabilities for the quantification of ethanol in water
(2022)
The accurate quantification of ethanol in water is essential for forensic applications such as blood and breath alcohol testing and for commercial applications such as the assessment of alcoholic beverages.
The intercomparison EURAMET.QM-S14 is part of a capacity building project named ALCOREF “Certified forensic alcohol reference materials”
that is running within the European Metrology Programme for Innovation and Research (EMPIR). The intercomparison should allow project partners and other interested National Metrology Institutes (NMIs) and Designated Institutes (DIs) to benchmark their analytical methods for the quantification of ethanol in water. The study plan was agreed by the European Association of National Metrology Institutes (EURAMET) Subcommittee Bio- and Organic Analysis (SCBOA) and the Organic Analysis Working Group (OAWG) of the Comité Consultatif pour la Quantité de Matière (CCQM) in February and April 2019, respectively. The intercomparison was coordinated by BAM. Two concentration levels relevant for the calibration and verification of evidential breath alcohol analysers were distributed to study participants. Fifteen institutes from 15 countries registered for the intercomparison and returned results. Participants mostly applied gas chromatography with flame ionisation detection (GC-FID) or mass spectroscopy (GC-MS), one participant used titrimetry and one participant employed a test bench for breath analyser calibration (“bubble train”). Participants did either in-house purity assessment of their commercial ethanol calibrants by Karl-Fischer titration, chromatographic methods, quantitative nuclear magnetic resonance spectroscopy (qNMR) and/or density measurements; or they used ethanol/water Certified Reference Materials (CRMs) from NMIs/DIs for calibration.
CCQM OAWG agreed to use a consensus value from participants results that utilizes the reported uncertainties as Key Comparison Reference Value (KCRV). The Gaussian Random effects model with Hierarchical Bayesian solution (HB-REM) is a reasonable approach in this case. The KCRVs and Degrees of Equivalence (DoEs) were calculated with the NIST consensus builder version 1.2 Hierarchical Bayes procedure.
Successful participation in the interlaboratory comparison has demonstrated the capabilities in determining the mass fraction of ethanol in aqueous matrices in the range 0.1 mg/g to 8 mg/g. Fourteen out of 15 participants have successfully quantified both samples, one participant successfully quantified only the lower-level (0.6 mg/g) sample.
Objectives: Using a murine model of multiple sclerosis, we previously showed that repeated administration of gadopentetate dimeglumine led to retention of gadolinium (Gd) within cerebellar structures and that this process was enhanced with inflammation. This study aimed to compare the kinetics and retention profiles of Gd in inflamed and healthy brains after application of the macrocyclic Gd-based contrast agent (GBCA) gadobutrol or the linear GBCA gadopentetate. Moreover, potential Gd-induced neurotoxicity was investigated in living hippocampal slices ex vivo.
Materials and Methods: Mice at peak of experimental autoimmune encephalomyelitis (EAE; n = 29) and healthy control mice (HC; n = 24) were exposed to a cumulative dose of 20 mmol/kg bodyweight of either gadopentetate dimeglumine or gadobutrol (8 injections of 2.5 mmol/kg over 10 days). Magnetic resonance imaging (7 T) was performed at baseline as well as at day 1, 10, and 40 post final injection (pfi) of GBCAs. Mice were sacrificed after magnetic resonance imaging and brain and blood Gd content was assessed by laser ablation-inductively coupled plasma (ICP)-mass spectrometry (MS) and ICP-MS, respectively. In addition, using chronic organotypic hippocampal slice cultures, Gd-induced neurotoxicity was addressed in living brain tissue ex vivo, both under control or inflammatory (tumor necrosis factor α [TNF-α] at 50 ng/μL) conditions.
Results: Neuroinflammation promoted a significant decrease in T1 relaxation times after multiple injections of both GBCAs as shown by quantitative T1 mapping of EAE brains compared with HC. This corresponded to higher Gd retention within the EAE brains at 1, 10, and 40 days pfi as determined by laser ablation-ICP-MS. In inflamed cerebellum, in particular in the deep cerebellar nuclei (CN), elevated Gd retention was observed until day 40 after last gadopentetate application (CN: EAE vs HC, 55.06 ± 0.16 μM vs 30.44 ± 4.43 μM). In contrast, gadobutrol application led to a rather diffuse Gd content in the inflamed brains, which strongly diminished until day 40 (CN: EAE vs HC, 0.38 ± 0.08 μM vs 0.17 ± 0.03 μM). The analysis of cytotoxic effects of both GBCAs using living brain tissue revealed an elevated cell death rate after incubation with gadopentetate but not gadobutrol at 50 mM. The cytotoxic effect due to gadopentetate increased in the presence of the inflammatory mediator TNF-α (with vs without TNF-α, 3.15% ± 1.18% vs 2.17% ± 1.14%; P = 0.0345).
Conclusions: In the EAE model, neuroinflammation promoted increased Gd retention in the brain for both GBCAs. Whereas in the inflamed brains, efficient clearance of macrocyclic gadobutrol during the investigated time period was observed, the Gd retention after application of linear gadopentetate persisted over the entire observational period. Gadopentetate but not gadubutrol appeared to be neurotoxic in an ex vivo paradigm of neuronal inflammation.
The paper presents a comparison between two different numerical modelling approaches aimed to simulate the in-plain behaviour of rammed earth walls, namely under axial, diagonal and cyclic shearcompression loading. In the first part of the study the mechanical characterisation of wallets tested under uniaxial compression and diagonal compression and walls tested under in-plane cyclic shear-compression loading is presented. The results were used to implement and validate the finite element simulations.
The numerical modelling of the rammed earth samples tested is then discussed in the second part. A non-linear constitutive law based on the total strain rotating crack model (TSRCM) was employed as implemented in the DIANA® software. The aim of the numerical analyses presented here is to simulate the behaviour of rammed earth under different inplane loading conditions. For the wallets, tests under static loading both macro- and micro-modelling
approaches were considered for the simulation of the experimental tests. For the walls subjected to cyclic loading only the micro-modelling approach was applied for the simulation of the experimental tests.
The respective FEM model was calibrated with the experimental results. The rammed earth layers were represented by continuum elements, the contact surfaces between layers by interface elements. This approach allowed assessing the influence of the apparent weakness of the interfaces between layers on the shear behaviour of rammed earth.
The goal of the numerical simulation of the cyclic tests was to establish the adequacy of common analytical methods (e. g. used for masonry) applied to the analysis of rammed earth. Rammed earth exhibits brittle characteristics similar to masonry materials and is used in geometrical typologies, such as walls, common in masonry construction.
Der Beitrag präsentiert einen Vergleich zwischen verschiedenen numerischen Modellierungsansätzen die dazu dienen sollen, das flächige Verhalten von Stampflehmwänden, genauer unter axialer, diagonaler und zyklischer Scherkraftbelastung zu simulieren.
Im ersten Teil der Studie werden die mechanischen Eigenschaften der Wandscheiben, die unter einachsiger und diagonaler Druckbelastung getestet wurde und der Wände, die in flächigen, zyklischen Scherkraftbelastung getestet wurden, dargestellt. Die Ergebnisse werden verwendet, um die Finite Elemente Simulation anzuwenden und zu bewerten. Die numerische Modellierung der getesteten Stampflehmproben
wird dann im zweiten Teil diskutiert. Ein nichtlineares Materialgesetz basierend auf dem Gesamtdehnungsrissmodell (total strain rotating crack model – TSRCM) wurde, wie durch die Software DIANA® verwendet, angesetzt. Ziel dieser hier präsentierten numerischen Analyse ist es, das Verhalten von Stampflehm unter verschiedenen Lasteinflüssen
zu simulieren. Für die Wandscheiben wurden Versuche unter linearer Last, sowohl in Makro- als auch Mikromodellansätze für die Simulation der experimentellen Versuche gewählt. Für die Wände, welche zyklischer Belastung ausgesetzt waren, wurden nur die Mikromodellansätze für die Simulation der experimentellen Versuche gewählt. Das betreffende FEM Modell wurde mit den experimentellen Ergebnissen kalibriert. Die Stampflehmlagen wurden mit durchgehenden Elementen, die Kontaktflächen zwischen den Lagen mit Oberflächenelementen repräsentiert.
Dieser Ansatz erlaubte die Bewertung des Einflusses der auftretenden Schwächung in den Oberflächen zwischen den Lagen auf das Scherverhalten des Stampflehms. Ziel der numerischen Simulation von zyklischen Versuchen war es, die Eignung allgemeiner Analysemethoden (z. B. für Mauerwerk) für die Analyse von Stampflehm einzuführen und anzuwenden. Stampflehm zeigt brüchige Eigenschaften vergleichbar zu Mauerwerksbaustoffen und wird in geometrischen Formen, wie Wänden, genutzt, die im Mauerwerk üblich sind.
The paper presents a comparison between different numerical modelling approaches aiming to simulate the in-plain behaviour of three types of earthen materials, namely adobe masonry, rammed earth and cob. For this purpose, uniaxial and diagonal compression tests were carried out, which allowed determining important mechanical parameters, such as compressive strength, Young’s modulus, Poisson’s ratio, shear strength and shear modulus. Furthermore, the tests allowed assessing the level of non-linear behaviour of the respective stress–strain relationships as well as the failure modes. The experimental results were then used for the calibration of numerical models (based on the finite element method) for simulating the non-linear behaviour of the earth materials under in-plane shear loading. Both macro- and micro-modelling approaches were considered for this purpose. The procedures adopted for model calibration established the reliability of various modelling strategies for the different loading conditions. The simplified Approach based on macromodelling shows a satisfactory accuracy and low computational costs. The results reproducing the uniaxial compression are in good correspondence with the post-elastic behaviour observed in the experimental campaign. The micro-modelling approach adopted to reproduce the shear behaviour, even with higher computational cost, represents a suitable tool to predict the adobe masonry and rammed earth collapse mechanisms.
Microbiologically influenced corrosion (MIC) is a phenomenon of increasing concern which affects various materials and sectors of society. MIC describes the effects, often negative, that a material can experience due to the presence of microorganisms. Unfortunately, although several research groups and industrial actors worldwide have already addressed MIC, discussions are fragmented, while information sharing and willingness to reach out to other disciplines is limited. A truly interdisciplinary approach, that would be logical for this material/biology/chemistry-related challenge, is rarely taken. In this review we highlight critical non-biological aspects of MIC that can sometimes be overlooked by microbiologists working on MIC but are highly relevant for an overall understanding of this phenomenon. Here, we identify gaps, methods and approaches to help solve MIC related challenges, with an emphasis on the MIC of metals. We also discuss the application of existing tools and approaches for managing MIC and propose ideas to promote an improved understanding of MIC. Furthermore, we highlight areas where the insights and expertise of microbiologists are needed to help progress this field.
Among the strategies to produce healable thermosetting systems is their modification by the addition of thermoplastic particles. This work investigates the influence of poly(ethylene-co-methacrylic acid) (EMAA) on fibermatrix interfacial properties of a glass fiber reinforced epoxy matrix composite. Epoxy-EMAA interactions were evaluated using differential scanning calorimetry (DSC) and infrared spectroscopy. The effects of EMAA on the epoxy network formation were evidenced by changes in glass transition temperature, cure kinetics and alteration of chemical groups during cure. Interfacial shear strength (IFSS) measurements obtained by single fiber pull-out tests indicate similar interfacial properties for pure and EMAA modified epoxy. Additionally, the potential for self-healing ability of an EMAA modified epoxy was demonstrated. However, IFSS after a healing cycle for the EMAA modified epoxy was lower as compared to the pure epoxy, because of the lower fiber-EMAA interfacial shear strength. So, thermoplastic healing agents has not only to fill cracks in the matrix material, but also have to be optimized regarding its interface properties to the reinforcing fibers.
The awareness of the environmental impact of the building sector is increasing. Steel reinforced concrete is the most commonly used construction material, though with a high-embodied energy and carbon footprint. Large environmental gains may arise if an alternative to steel reinforced concrete is developed. In this context, ultra-high performance concrete (UHPC) materials are shown to be promising alternatives with advantages such as lower embodied energy and reduced environmental impact. Predictions suggest that UHPC composite elements for building envelopes could have other benefits such as an increased service life, optimised use of building area due to thinner elements and minimised maintenance due to the absence of reinforcement or use of non-corrosive reinforcing materials such as carbon fibres. In the framework of the H-HOUSE project funded by the European Commission, composite elements are developed. The aim is to create facade panels combining an autoclaved aerated concrete or cellular lightweight concrete insulation layer with an external UHPC supporting layer. To enhance occupant comfort and health, hygroscopic materials that are capable to buffer indoor air humidity shall be applied to the inside of such elements. Indoor air humidity levels are expected to be more stable, which shall subsequently improve the indoor climate and minimise potential decay to the construction.
The awareness of the environmental impact of the building sector is increasing. Steel reinforced concrete is the most commonly used construction material, though with a high-embodied energy and carbon footprint. Large environmental gains may arise if an alternative to steel reinforced concrete is developed. In this context, ultra-high performance concrete (UHPC) materials are shown to be promising alternatives with advantages such as lower embodied energy and reduced environmental impact. Predictions suggest that UHPC composite elements for building envelopes could have other benefits such as an increased service life, optimised use of building area due to thinner elements and minimised maintenance due to the absence of reinforcement or use of non-corrosive reinforcing materials such as carbon fibres. In the framework of the H-HOUSE project funded by the European Commission, composite elements are developed. The aim is to create facade panels combining an autoclaved aerated concrete or cellular lightweight concrete insulation layer with an external UHPC supporting layer. To enhance occupant comfort and health, hygroscopic materials that are capable to buffer indoor air humidity shall be applied to the inside of such elements. Indoor air humidity levels are expected to be more stable, which shall subsequently improve the indoor climate and minimise potential decay to the construction.
The paper presents the results of a series of combined mechanical and in-situ morphological investigations on highstrength strain-hardening cement-based Composites (SHCC). Tension and compression experiments were performed in a CT scanner employing a dedicated mechanical testing rig. The in-situ microtomographic scans enabled correlating the measured specimen response with relevant microstructural features and fracture processes. The microstructural segmentation of SHCC was performed in the framework of Deep Learning and it targeted an accurate segmentation of pores, fibers and aggregates. Besides their accurate volumetric representation, these phases were quantified in terms of content, size and orientation. The fracture processes were monitored at different loading stages and Digital Volume Correlation (DVC) was employed to spatially map the strains and cracks in the specimens loaded in compression. The DVC analysis highlighted the effect of loading conditions, specimen geometry and material heterogeneity at the mesolevel on the strain distribution and fracture localization.