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Organisationseinheit der BAM
This report describes the methodology of the reliability investigation performed on the ultrasonic
phased array NDT system, developed by SKB in collaboration with Posiva, for inspection of the
canisters for permanent storage of nuclear spent fuel.
The canister is composed of a cast iron insert surrounded by a copper shell. The shell is composed
of the tube and the lid/base which are welded to the tube after the fuel has been place, in the
tube. The manufacturing process of the canister parts and the welding process are described.
Possible defects, which might arise in the canister components during the manufacturing
or in the weld during the welding, are indentified.
The number of real defects in manufactured components have been limited. Therefore the reliability
of the NDT system has been determined using a number of test objects with artifical defects.
The reliability analysis is based on the signal response analysis. The conventional signal response
analysis is adopted and further developed before applied on the modern ultrasonic phased-array
NDT system. The concept of multi-parameter a, where the response of the NDT system is dependent
on more than just one parameter, is introduced. The weakness of use of the peak signal response
in the analysis is demonstrated and integration of the amplitudes in the C-scan is proposed as an
alternative. The calculation of the volume POD, when the part is inspected with more configurations,
is also presented. The reliability analysis is supported by the ultrasonic simulation based on the
point source synthesis method.
A modern day light microscope has evolved from a tool devoted to making primarily empirical observations to what is now a sophisticated, quantitative device that is an integral part of both physical and life science research. Nowadays, microscopes are found in nearly every experimental laboratory. However, despite their prevalent use in capturing and quantifying scientific phenomena, neither a thorough understanding of the principles underlying quantitative imaging techniques nor appropriate knowledge of how to calibrate, operate and maintain microscopes can be taken for granted. This is clearly demonstrated by the well-documented and widespread difficulties that are routinely encountered in evaluating acquired data and reproducing scientific experiments. Indeed, studies have shown that more than 70% of researchers have tried and failed to repeat another scientist’s experiments, while more than half have even failed to reproduce their own experiments1. One factor behind the reproducibility crisis of experiments published in scientific journals is the frequent underreporting of imaging methods caused by a lack of awareness and/or a lack of knowledge of the applied technique2,3. Whereas quality control procedures for some methods used in biomedical research, such as genomics (e.g., DNA sequencing, RNA-seq) or cytometry, have been introduced (e.g. ENCODE4), this issue has not been tackled for optical microscopy instrumentation and images. Although many calibration standards and protocols have been published, there is a lack of awareness and agreement on common Standards and guidelines for quality assessment and reproducibility5.
In April 2020, the QUality Assessment and REProducibility for instruments and images in Light Microscopy (QUAREP-LiMi) initiative6 was formed. This initiative comprises imaging scientists from academia and industry who share a common interest in achieving a better understanding of the performance and limitations of microscopes and improved quality control (QC) in light microscopy. The ultimate goal of the QUAREP-LiMi initiative is to establish a set of common QC standards, guidelines, metadata models7,8, and tools9,10, including detailed protocols, with the ultimate aim of improving reproducible advances in scientific research.
This White Paper 1) summarizes the major obstacles identified in the field that motivated the launch of the QUAREP-LiMi initiative; 2) identifies the urgent need to address these obstacles in a grassroots manner, through a community of Stakeholders including, researchers, imaging scientists11, bioimage analysts, bioimage informatics developers, corporate partners, Funding agencies, standards organizations, scientific publishers, and observers of such; 3) outlines the current actions of the QUAREPLiMi initiative, and 4) proposes future steps that can be taken to improve the dissemination and acceptance of the proposed guidelines to manage QC.
To summarize, the principal goal of the QUAREP-LiMi initiative is to improve the overall quality and reproducibility of light microscope image data by introducing broadly accepted standard practices and accurately captured image data metrics.
The community-driven initiative Quality Assessment and Reproducibility for Instruments & Images in Light Microscopy (QUAREP-LiMi) wants to improve reproducibility for light microscopy image data through Quality control (QC) management of instruments and images. It aims for a common set of QC guidelines for Hardware calibration and image acquisition, management and analysis.