Structural changes in plasmid DNA verified by gel electrophoresis and AFM: Sample radiation and damage detection
- Many microorganisms possess circular molecules of plasmid DNA. Their conformation may vary from more compact to relaxed forms. Structural changes have important consequences for the physiological role of plasmids and will influence plasmid transcription, replication and their susceptibility to environmental stresses. Radiation is a common form of stress and can cause structural damage to DNA such as single (SSB) and double strand breaks (DSB). Recently, it has been indicated that secondary low-energy electrons play an important role in biological damage under vacuum condition. Therefore, our studies focus on irradiating the plasmid pUC19 with low-energy electrons for the first time under physiological conditions.
Autor*innen: | Susann Meyer |
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Koautor*innen: | Astrid-Maria Schröter, Marc Benjamin HahnORCiD, Tihomir Solomun, Heinz SturmORCiD, Hans-Jörg KunteORCiD |
Dokumenttyp: | Posterpräsentation |
Veröffentlichungsform: | Präsentation |
Sprache: | Englisch |
Jahr der Erstveröffentlichung: | 2016 |
DDC-Klassifikation: | Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Sanitär- und Kommunaltechnik; Umwelttechnik |
Freie Schlagwörter: | DNA; Irradiation damage; Low energy electrons |
Veranstaltung: | AFM BioMed Conference |
Veranstaltungsort: | Porto, Portugal |
Beginndatum der Veranstaltung: | 11.04.2016 |
Enddatum der Veranstaltung: | 15.04.2016 |
Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
Datum der Freischaltung: | 28.04.2016 |
Referierte Publikation: | Nein |