Optimal control for a tuberculosis model with undetected cases in Cameroon

  • This paper considers the optimal control of tuberculosis through education, diagnosis campaign and chemoprophylaxis of latently infected. A mathematical model which includes important components such as undiagnosed infectious, diagnosed infectious, latently infected and lost-sight infectious is formulated. The model combines a frequency dependent and a density dependent force of infection for TB transmission. Through optimal control theory and numerical simulations, a cost-effective balance of two different intervention methods is obtained. Seeking to minimize the amount of money the government spends when tuberculosis remain endemic in the Cameroonian population, Pontryagin's maximum principle is used to characterize the optimal control. The optimality system is derived and solved numerically using the forward-backward sweep method (FBSM). Results provide a framework for designing cost-effective strategies for diseases with multiple intervention methods. It comes out that combining chemoprophylaxis and education, the burden of TB can be reduced by 80 % in 10 years.
Author:Dany Pascal Moualeu-Ngangue, Martin WeiserORCiD, Rainald Ehrig, Peter Deuflhard
Document Type:Article
Parent Title (English):Communications in Nonlinear Science and Numerical Simulation
First Page:986
Last Page:1003
Year of first publication:2015