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Epidemiological analysis of Leishmania tropica strains and giemsa-stained smears from Syrian and Turkish leishmaniasis patients using multilocus microsatellite typing (MLMT)

  • Turkey is located in an important geographical location, in terms of the epidemiology of vector-borne diseases, linking Asia and Europe. Cutaneous leishmaniasis (CL) is one of the endemic diseases in a Turkey and according to the Ministry Health of Turkey, 45% of CL patients originate from Şanlıurfa province located in southeastern Turkey. Herein, the epidemiological status of CL, caused by L. tropica, in Turkey was examined using multilocus microsatellite typing (MLMT) of strains obtained from Turkish and Syrian patients. A total of 38 cryopreserved strains and 20 Giemsa-stained smears were included in the present study. MLMT was performed using 12 highly specific microsatellite markers. Delta K (ΔK) calculation and Bayesian statistics were used to determine the population structure. Three main populations (POP A, B and C) were identified and further examination revealed the presence of three subpopulations for POP B and C. Combined analysis was performed using the data of previously typed L. tropica strains and Mediterranean and Şanlıurfa populations were identified. This finding suggests that the epidemiological status of L. tropica is more complicated than expected when compared to previous studies. A new population, comprised of Syrian L. tropica samples, was reported for the first time in Turkey, and the data presented here will provide new epidemiological information for further studies.

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Metadaten
Verfasserangaben:Mehmet Karakuş, Abed Nasereddin, Hüseyin Onay, Emin Karaca, Ahmet Özkeklikçi, Charles L. Jaffe, Katrin KuhlsORCiD, Ahmet Özbilgin, Hatice Ertabaklar, Samiye Demir, Yusuf Özbel, Seray Töz
URN:urn:nbn:de:kobv:526-opus4-9313
DOI:https://doi.org/10.1371/journal.pntd.0005538
ISSN:1935-2735
Titel des übergeordneten Werkes (Englisch):PLoS Neglected Tropical Diseases
Dokumentart:Wissenschaftlicher Artikel
Sprache:Englisch
Erscheinungsjahr:2017
Veröffentlichende Institution:Technische Hochschule Wildau
Datum der Freischaltung:26.04.2017
Jahrgang:11
Ausgabe / Heft:4
Seitenzahl:12
Quelle:Karakuş M, Nasereddin A, Onay H, Karaca E, Özkeklikçi A, Jaffe CL, et al. (2017) Epidemiological analysis of Leishmania tropica strains and giemsa-stained smears from Syrian and Turkish leishmaniasis patients using multilocus microsatellite typing (MLMT). PLoS Negl Trop Dis 11(4): e0005538. https://doi.org/10.1371/journal.pntd.0005538
Fachbereiche und Einrichtungen:Fachbereich Ingenieur- und Naturwissenschaften
DDC-Klassifikation:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Lizenz (Deutsch):Creative Commons - CC BY - Namensnennung 4.0 International
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