SNP microarray analyses reveal copy number alterations and progressive genome reorganization during tumor development in SVT/t driven mice breast cancer
- Tumor development is known to be a stepwise process involving dynamic changes that affect cellular integrity and cellular behavior. This complex interaction between genomic organization and gene, as well as protein expression is not yet fully understood. Tumor characterization by gene expression analyses is not sufficient, since expression levels are only available as a snapshot of the cell status. So far, research has mainly focused on gene expression profiling or alterations in oncogenes, even though DNA microarray platforms would allow for high-throughput analyses of copy number alterations (CNAs).
Author: | Christoph Standfuß, Heike Pospisil, Andreas Klein |
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URN: | urn:nbn:de:kobv:526-opus4-6414 |
DOI: | https://doi.org/10.1186/1471-2407-12-380 |
ISSN: | 1471-2407 |
Parent Title (English): | BMC Cancer |
Document Type: | Article |
Language: | English |
Year of Publication: | 2012 |
Publishing Institution: | Technische Hochschule Wildau |
Release Date: | 2016/07/06 |
Tag: | CNV; breast cancer; copy number alteration; fragile sites; genome reorganization |
Volume: | 12 |
Issue: | 380 |
Page Number: | 15 |
Source: | Standfuß et al.: SNP microarray analyses reveal copy number alterations and progressive genome reorganization during tumor development in SVT/t driven mice breast cancer. BMC Cancer 2012 12:380. |
Faculties an central facilities: | Fachbereich Ingenieurwesen / Wirtschaftsingenieurwesen (bis 8/2014) |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten |
Licence (German): | Creative Commons - CC BY - Namensnennung 2.0 Generic |