TY - JOUR A1 - Standfuß, Christoph A1 - Pospisil, Heike A1 - Klein, Andreas T1 - SNP microarray analyses reveal copy number alterations and progressive genome reorganization during tumor development in SVT/t driven mice breast cancer TI - BMC Cancer N2 - Tumor development is known to be a stepwise process involving dynamic changes that affect cellular integrity and cellular behavior. This complex interaction between genomic organization and gene, as well as protein expression is not yet fully understood. Tumor characterization by gene expression analyses is not sufficient, since expression levels are only available as a snapshot of the cell status. So far, research has mainly focused on gene expression profiling or alterations in oncogenes, even though DNA microarray platforms would allow for high-throughput analyses of copy number alterations (CNAs). KW - breast cancer KW - genome reorganization KW - copy number alteration KW - CNV KW - fragile sites Y1 - 2012 UR - https://opus4.kobv.de/opus4-th-wildau/frontdoor/index/index/docId/641 UR - https://nbn-resolving.org/urn:nbn:de:kobv:526-opus4-6414 SN - 1471-2407 VL - 12 IS - 380 ER -