Somatic loss of function mutations in neurofibromin 1 and MYC associated factor X genes identified by exome-wide sequencing in a wild-type GIST case
- Approximately 10–15 % of gastrointestinal stromal tumors (GISTs) lack gain of function mutations in the KIT and platelet-derived growth factor receptor alpha (PDGFRA) genes. An alternate mechanism of oncogenesis through loss of function of the succinate-dehydrogenase (SDH) enzyme complex has been identified for a subset of these “wild type” GISTs.
Author: | Martin G. Belinsky, Lori Rink, Kathy Q. Cai, Stephen J. Capuzzi, Yen Hoang, Jeremy ChienORCiD, Andrew K. Godwin, Margaret von Mehren |
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URN: | urn:nbn:de:kobv:526-opus4-6292 |
DOI: | https://doi.org/10.1186/s12885-015-1872-y |
ISSN: | 1471-2407 |
Parent Title (English): | BMC Cancer |
Document Type: | Article |
Language: | English |
Year of Publication: | 2015 |
Publishing Institution: | Technische Hochschule Wildau |
Release Date: | 2016/07/05 |
Tag: | KIT; MAX; NF1; PDGFRA; gastrointestinal stromal tumor (GIST); succinate dehydrogenase (SDH); wild type |
Volume: | 15 |
Issue: | 887 |
Source: | Belinsky et al. Somatic loss of function mutations in neurofibromin 1 and MYC associated factor X genes identified by exome-wide sequencing in a wild-type GIST case. BMC Cancer (2015) 15:887 |
Faculties an central facilities: | Fachbereich Ingenieur- und Naturwissenschaften |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten |
Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |