Complexation with C60 Fullerene Increases Doxorubicin Efficiency against Leukemic Cells In Vitro

  • Conventional anticancer chemotherapy is limited because of severe side effects as well as a quickly evolving multidrug resistance of the tumor cells. To address this problem, we have explored a C60 fullerene-based nanosized system as a carrier for anticancer drugs for an optimized drug delivery to leukemic cells. Here, we studied the physicochemical properties and anticancer activity of C60 fullerene noncovalent complexes with the commonly used anticancer drug doxorubicin. C60-Doxorubicin complexes in a ratio 1:1 and 2:1 were characterized with UV/Vis spectrometry, dynamic light scattering, and high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The obtained analytical data indicated that the 140-nm complexes were stable and could be used for biological applications. In leukemic cell lines (CCRF-CEM, Jurkat, THP1 and Molt-16), the nanocomplexes revealed ≤ 3.5 higher cytotoxic potential in comparison with the free drug in a range of nanomolar concentrations. Also, the intracellular drug’s level evidenced C60 fullerene considerable nanocarrier function. The results of this study indicated that C60 fullerene-based delivery nanocomplexes had a potential value for optimization of doxorubicin efficiency against leukemic cells.

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Author:Anna GrebinykORCiD, Svitlana PrylutskaORCiD, Sergii GrebinykORCiD, Yuriy Prylutskyy, Uwe RitterORCiD, Olga Matyshevska, Thomas DandekarORCiDGND, Marcus FrohmeORCiDGND
Parent Title (English):Nanoscale Research Letters
Document Type:Article
Year of Publication:2019
Publishing Institution:Technische Hochschule Wildau
Release Date:2019/03/15
Source:Grebinyk, A., Prylutska, S., Grebinyk, S. et al. Nanoscale Res Lett (2019) 14: 61.
Faculties an central facilities:Fachbereich Ingenieur- und Naturwissenschaften
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Funding:DFG-geförderter Publikationsfonds
Licence (German):Creative Commons - CC BY - Namensnennung 4.0 International
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