Double and Multiple Knockout Simulations for Genome-Scale Metabolic Network Reconstructions

Please always quote using this URN:urn:nbn:de:0296-matheon-12815
  • Constraint-based modeling of genome-scale metabolic network reconstructions has become a widely used approach in computational biology. Flux coupling analysis is a constraint-based method that analyses the impact of single reaction knockouts on other reactions in the network.We present an extension of flux coupling analysis for double and multiple gene or reaction knockouts, and develop corresponding algorithms for an in silico simulation. To evaluate our method, we perform a full single and double knockout analysis on a selection of genome-scale metabolic network reconstructions and compare the results.

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Author:Yaron A. B. Goldstein, Alexander Bockmayr
Referee:Peter Deuflhard
Document Type:Preprint, Research Center Matheon
Date of first Publication:2014/04/14
Release Date:2014/04/14
Tag:constraint-based modeling; flux coupling analysis; knockout simulation; metabolic network
Institute:Research Center Matheon
Freie Universität Berlin
MSC-Classification:92-XX BIOLOGY AND OTHER NATURAL SCIENCES / 92Cxx Physiological, cellular and medical topics / 92C42 Systems biology, networks
Preprint Number:1055
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