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Exploiding termite nest microbiomes for antibiotic drug discovery using an integrated high throughput Microfluidics/FACS pipeline (2017)
Oberpaul, Markus ; Ngyuen, Mai ; Fracowiak, Jochen ; Zubeil, Florian ; Plarre, Rüdiger ; Hammann, Peter ; Vilcinskas, Andreas ; Gläser, Jens
Bacterial infections are a global threat to human health1. Especially nosocomial infections with multidrug-resistant Gram-negative bacteria challenge public health systems and endanger successful treatment of patients in various modern medicine applications as e.g. organ transplant. In the last three decades classical approaches failed to find novel chemical scaffolds suitable for the development of antibiotics. Insect microbiomes produce potent antibiotics with low toxicity to eukaryotic cells to defend their hosts against entomopathogenic microorganisms2. In order to exploit insect microbiomes efficiently and to identify novel antibiotic producing bacteria, we implemented an high throughput Microfluidics/FACS (fluorescence-associated cell sorting) cultivation and screening pipeline. Here, we present the technical aspects of our pipeline including downstream processing. This includes genomic fingerprinting of identified producer strains, metabolomic analysis and isolation of natural products.
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