Filtern
Erscheinungsjahr
- 2015 (1) (entfernen)
Dokumenttyp
Sprache
- Englisch (1)
Referierte Publikation
- ja (1)
Schlagworte
- Chlorine (1)
- Konjugate (1)
- Kopplungsmethoden (1)
- Krebstherapie (1)
- Photodynamische Therapie (1)
- Phthalocyanine (1)
- Porphyrine (1)
- Therapeutische Antikörper (1)
Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications
(2015)
Targeting photosensitizers to cancer cells by conjugating them with specific antibodies, able to recognize and bind to tumor-associated antigens, is today one of the most attractive strategies in photodynamic therapy (PDT). This comprehensive review updates on chemical routes available for the preparation of photo-immunoconjugates (PICs), which show dual chemical and biological functionalities: photo-properties of the photosensitizer and the immunoreactivity of the antibody. Moreover, photobiological results obtained with such photo-immunoconjugates using in vitro and in vivo cancer models are also discussed.