Degradation kinetics of the Alternaria mycotoxin tenuazonic acid in aqueous solutions
- The degradation kinetics of the Alternaria mycotoxin tenuazonic acid (l-TA) in aqueous buffer were studied over a period of 4 months at different pH levels (3.5 and 7.0) and temperatures (4, 25 and 40°C). l-TA and its degradation products were quantified by newly developed high-performance liquid chromatography methods with UV or electrospray multistage mass spectrometry detection. At pH 3.5, significant degradation occurred at 25 and 40°C, the respective l-TA half-lives being 73.8±0.4 and 14.0±0.1 days. Two degradation processes, epimerization and hydrolysis, were evaluated kinetically. The hydrolytically formed iso-deacetyl TA (iso-DTA, epimeric mixture) was found to be the stable end product of l-TA degradation under the conditions of this study. This indicates that iso-DTA as well as the l-TA epimer u-TA are formed in aqueous beverage matrices.
Autor*innen: | David Siegel, Stefan Merkel, Wolfram Bremser, Matthias KochORCiD, Irene Nehls |
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Dokumenttyp: | Zeitschriftenartikel |
Veröffentlichungsform: | Verlagsliteratur |
Sprache: | Englisch |
Titel des übergeordneten Werkes (Englisch): | Analytical and bioanalytical chemistry |
Jahr der Erstveröffentlichung: | 2010 |
Verlag: | Springer |
Verlagsort: | Berlin |
Jahrgang/Band: | 397 |
Ausgabe/Heft: | 2 |
Erste Seite: | 453 |
Letzte Seite: | 462 |
Freie Schlagwörter: | Alternaria; Degradation; Epimerization; Kinetics; Tenuazonic acid |
DOI: | 10.1007/s00216-009-3288-5 |
ISSN: | 1618-2642 |
ISSN: | 1618-2650 |
Verfügbarkeit des Dokuments: | Physisches Exemplar in der Bibliothek der BAM vorhanden ("Hardcopy Access") |
Bibliotheksstandort: | Sonderstandort: Publica-Schrank |
Datum der Freischaltung: | 19.02.2016 |
Referierte Publikation: | Ja |
Datum der Eintragung als referierte Publikation: | 07.06.2010 |