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Modeling potassium balance in dairy cows

Please always quote using this URN: urn:nbn:de:0297-zib-17749
  • Potassium is fundamental for cell functioning including signal transduction, acid-base- and water-metabolism. Since diet of dairy cows is generally rich in potassium, hypokalemia was not in the focus of research for long time. Furthermore, hypokalemia was not frequently diagnosed because blood potassium content is difficult to measure. In recent years, measurement methods have been improved. Nowadays hypokalemia is increasingly diagnosed in cows with disorders such as abomasal displacement, ketosis or down cow syndrome, calling for intensified research on this topic. In this report we describe the development of a basic mechanistic, dynamic model of potassium balance based on ordinary differential and algebraic equations. Parameter values are obtained from data of a clinical trial in which potassium balance and the influence of therapeutic intervention in glucose and electrolyte metabolism on potassium balance in non-lactating dairy cows were studied. The model is formulated at a high abstraction level and includes information and hypotheses from literature. This work represents a first step towards the understanding and design of effective prophylactic feed additives and treatment strategies.

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Author:Julia Plöntzke, Mascha Berg, Amiya Olany, Sabine Leonhard-Marek, Kerstin-Elisabeth Müller, Susanna RöblitzORCiD
Document Type:ZIB-Report
Tag:differential equations; metabolism; systems biology
MSC-Classification:92-XX BIOLOGY AND OTHER NATURAL SCIENCES / 92Cxx Physiological, cellular and medical topics / 92C30 Physiology (general)
92-XX BIOLOGY AND OTHER NATURAL SCIENCES / 92Cxx Physiological, cellular and medical topics / 92C42 Systems biology, networks
Date of first Publication:2013/02/14
Series (Serial Number):ZIB-Report (13-09)
Licence (German):License LogoCreative Commons - Namensnennung-Keine kommerzielle Nutzung-Weitergabe unter gleichen Bedingungen
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