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Upgrading hundreds of thousands of already available CPAP home therapy machines to function as BIPAP/Bilevel machines may help to mitigate the current global threat of a shortage of ventilators. The concept may help to prevent the scenario that soon potentially thousands of COVID-19 patients will not be able to receive the necessary and sometimes life-saving respiratory support. This solution could be made available in very short time, because it is purely software based.
Das Upgrade von hunderttausenden vorhandenen CPAP-Heimtherapiegeräten mit BIPAP/Biphase-Beatmungsfunktionalität kann dazu beitragen, der momentan drohenden weltweiten Beatmungsgeräteknappheit entgegenzuwirken und zu verhindern, dass vielleicht bald tausende COVID19-Patienten nicht die erforderliche, teils lebensrettende Atemunterstützung erhalten können. Diese Lösung könnte in kürzester Zeit zur Verfügung gestellt werden, da sie rein softwarebasiert ist.
In a randomized controlled multiple cross-over trial, the effect of a single application of 1000 and 3000 F.I.P. bromelain on 6 cytokines, of male healthy volunteers was studied. The analysis of cytokines (Interferon gamma, IL-2, IL-6, IL8, IL-10, IL13 and MCP-1) was performed with the TrueCulture(tm) whole-blood culture system (EDI GmbH). With a single dose of 3000 F. I. P. bromelain, IFNgamma was found to be significantly stimulated in the afternoon hours compared to placebo (p = 0.043; Mixed Linear Model, Bonferroni adjusted).