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The present article is an attempt to elucidate the epistemological- ethical significance of the x experience in humanistic psychology and ethics. The aim is to show the epistemological-ethical relevance of the x experience phenomenon for developing a new integral self-understanding of the scientific task as a integral anthropology. The aim is to pick up where Fromm left off in his previously unpublished, cautiously formulated programmatic essay entitled >Institute for the Science of Man.< The article begins with a section looking at Fromm’s conception of >the conscious mind< and >the unconscious<. Particularly stressed here is the radical reform of the Freudian concept of >the unconscious< undertaken by Fromm in his analytical social psychology and humanist psychoanalysis. The second section outlines what the x experience phenomenon is and explains its importance for humanistic psychoanalysis. Fromm’s concept of >derepression< is presented and its important anthropological and epistemological implications discussed. The fact that there had been as good as no scientific study of the logic of the x experience, nor of its epistemological, ethical and anthropological implications, led Fromm to call for what he called an >empirically based psychological anthropology<, which would serve as the basis for all individual disciplines within the human sciences. The third section, given the heading >The Importance of the X- Experience in Humanistic Psychoanalysis for Achieving an Integrally Expanded Self-Understanding in the Sciences and in Mankind,< takes Armin Bader’s epistemological ideal of a integrally expanded self-understanding (the so-called comprehensive method of research) as a key starting point from which a theoretical scientific basis can then be developed for purposes of realizing the Frommian ideal of science as integral anthropology. The article closes by discussing the significance of the x experience for the development of an evolutionary theory of man.