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We consider the problem of pattern detection in large scale
railway timetables. This problem arises in rolling stock optimization planning
in order to identify invariant sections of the timetable for
which a cyclic rotation plan is adequate.
We propose a dual reduction technique which leads to an decomposition
and enumeration method. Computational results for real
world instances demonstrate that the method is able to
produce optimal solutions as fast as standard MIP solvers.
In this paper, we present a new, optimization-based method to exhibit cyclic behavior in non-reversible stochastic processes. While our method is general, it is strongly motivated by discrete simulations of ordinary differential equations representing non-reversible biological processes, in particular molecular simulations. Here, the discrete time steps of the simulation are often very small compared to the time scale of interest, i.e., of the whole process. In this setting, the detection of a global cyclic behavior of the process becomes difficult because transitions between individual states may appear almost reversible on the small time scale of the simulation. We address this difficulty using a mixed-integer programming model that allows us to compute a cycle of clusters with maximum net flow, i.e., large forward and small backward probability. For a synthetic genetic regulatory network consisting of a ring-oscillator with three genes, we show that this approach can detect the most productive overall cycle, outperforming classical spectral analysis methods. Our method applies to general non-equilibrium steady state systems such as catalytic reactions, for which the objective value computes the effectiveness of the catalyst.
State-of-the-art solvers for mixed integer programs (MIP) govern a variety of algorithmic components. Ideally, the solver adaptively learns to concentrate its computational budget on those components that perform well on a particular problem, especially if they are time consuming. We focus on three such algorithms, namely the classes of large neighborhood search and diving heuristics as well as Simplex pricing strategies. For each class we propose a selection strategy that is updated based on the observed runtime behavior, aiming to ultimately select only the best algorithms for a given instance. We review several common strategies for such a selection scenario under uncertainty, also known as Multi Armed Bandit Problem. In order to apply those bandit strategies, we carefully design reward functions to rank and compare each individual heuristic or pricing algorithm within its respective class. Finally, we discuss the computational benefits of using the proposed adaptive selection within the SCIP Optimization Suite on publicly available MIP instances.