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- Optimal Experimental Design (3)
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We prove a mathematical programming characterisation of approximate partial D-optimality under general linear constraints. We use this characterisation with a branch-and-bound method to compute a list of all exact D-optimal designs for estimating a pair of treatment contrasts in the presence of a nuisance time trend up to the size of 24 consecutive trials.
We study a family of combinatorial optimization problems
defined by a parameter $p\in[0,1]$, which involves spectral
functions applied to positive semidefinite matrices, and has
some application in the theory of optimal experimental design.
This family of problems tends to a generalization of the classical
maximum coverage problem as $p$ goes to $0$, and to a trivial instance
of the knapsack problem as $p$ goes to $1$.
In this article, we establish a matrix inequality which shows that the objective function is submodular for all $p\in[0,1]$, from which it follows
that the greedy approach, which has often been used for this problem, always gives a design within $1-1/e$ of the optimum.
We next study the design found by rounding the solution of the continuous relaxed problem, an approach which has been applied by several authors.
We prove an inequality which generalizes a classical result from the theory
of optimal designs, and allows us to give a rounding procedure with an approximation
factor which tends to $1$ as $p$ goes to $1$.
In the past few years several applications of optimal
experimental designs have emerged to optimize the measurements
in communication networks. The optimal design problems arising from
this kind of applications share three interesting properties:
(i) measurements are only available at a small number of locations of the network;
(ii) each monitor can simultaneously measure several quantities, which
can be modeled by ``multiresponse experiments";
(iii) the observation matrices depend on the topology of the network.
In this paper, we give an overview of these experimental design
problems and recall recent results for the computation of optimal
designs by Second Order Cone Programming (SOCP). New results for the
network-monitoring of a discrete time process are presented. In particular, we show
that the optimal design problem for the monitoring of an AR1 process can be reduced
to the standard form and we give experimental results.
We present a new semidefinite representation for the trace of
a real function f applied to symmetric matrices, when a
semidefinite representation of the convex function f is known. Our construction
is intuitive, and yields a representation that is more compact than the previously known one.
We also show with the help of matrix geometric means and the Riemannian metric of the set of positive definite matrices
that for a rational number p in the interval (0,1],
the matrix X raised to the exponent p is the largest element
of a set represented by linear matrix inequalities.
We give numerical results for a problem inspired from the theory
of experimental designs, which show that the new semidefinite programming formulation
yields a speed-up factor in the order of 10.
We show that a class of semidefinite programs (SDP) admits a solution that is a positive semidefinite
matrix of rank at most $r$, where $r$ is the rank of the matrix involved in the objective function of the SDP.
The optimization problems of this class are semidefinite packing problems,
which are the SDP analogs to vector packing problems.
Of particular interest is the case in which our result guarantees the existence of a solution
of rank one: we show that the computation of this solution actually reduces to a
Second Order Cone Program (SOCP).
We point out an application in statistics, in the optimal design of experiments.
PICOS is a user friendly interface
to several conic and integer programming solvers,
very much like YALMIP
under MATLAB.
The main motivation for PICOS is to have the possibility to
enter an optimization problem as a high level model,
and to be able to solve it with several different solvers.
Multidimensional and matrix variables are handled in a natural fashion,
which makes it painless to formulate a SDP or a SOCP.
This is very useful for educational purposes,
and to quickly implement some models and
test their validity on simple examples.
Furthermore, with PICOS you can take advantage of the
python programming language to read and write data,
construct a list of constraints by using python list comprehensions,
take slices of multidimensional variables, etc.
We propose an algorithm to approximate the distribution of the completion time (makespan)
and the tardiness costs of a project, when durations are lognormally distributed. This problem arises naturally for the optimization of surgery scheduling,
where it is very common to assume lognormal procedure times. We present an analogous of Clark's formulas to compute the moments of the maximum of a set of
lognormal variables. Then, we use moment matching formulas to approximate the earliest starting time of each activity of the project by a shifted lognormal variable.
This approach can be seen as a lognormal variant of a state-of-the-art method used for the statistical static timing analysis (SSTA) of digital circuits.
We carried out numerical experiments with instances based on real data from the application to surgery scheduling. We obtained very
promising results, especially for the approximation of the mean overtime in operating rooms,
for which our algorithm yields results of a similar quality to Monte-Carlo simulations
requiring an amount of computing time several orders of magnitude larger.
Robust Allocation of Operating Rooms: a Cutting Plane Approach to handle Lognormal Case Durations
(2016)
The problem of allocating operating rooms (OR) to surgical cases is a challenging task, involving both combinatorial aspects
and uncertainty handling. We formulate this problem as a parallel machines scheduling problem, in which job durations follow a lognormal distribution,
and a fixed assignment of jobs to machines must be computed.
We propose a cutting-plane approach to solve the robust counterpart of this optimization problem.
To this end, we develop an algorithm based on fixed-point iterations that identifies worst-case scenarios and generates cut inequalities.
The main result of this article uses Hilbert's projective geometry to prove the convergence of this procedure under mild conditions.
We also propose two exact solution methods for a similar problem, but with a polyhedral uncertainty set, for which
only approximation approaches were known. Our model can
be extended to balance the load over several planning periods in a rolling horizon.
We present extensive numerical experiments for instances based on real data from a major hospital in Berlin. In particular, we find that:
(i) our approach performs well compared to a previous model that ignored the distribution of case durations;
(ii) compared to an alternative stochastic programming approach, robust optimization yields solutions that are more robust against uncertainty, at a small price in terms of average cost;
(iii) the \emph{longest expected processing time first} (LEPT) heuristic performs well and efficiently protects against extreme scenarios, but only if a good prediction model for the durations is available.
Finally, we draw a number of managerial implications from these observations.
Let G be a directed acyclic graph with n arcs, a source s and a sink t. We introduce the cone K of flow matrices, which is a polyhedral cone
generated by the matrices $\vec{1}_P\vec{1}_P^T\in\RR^{n\times n}$, where
$\vec{1}_P\in\RR^n$ is the incidence vector of the (s,t)-path P.
We show that several hard flow (or path) optimization problems, that cannot be solved by using the standard arc-representation
of a flow, reduce to a linear optimization problem over $\mathcal{K}$.
This cone is intractable: we prove that the membership problem associated to $\mathcal{K}$
is NP-complete. However, the affine hull of this cone admits a nice description,
and we give an algorithm which computes in polynomial-time the decomposition of a matrix
$X\in \operatorname{span} \mathcal{K}$ as a linear combination of some $\vec{1}_P\vec{1}_P^T$'s.
Then, we provide two convergent approximation hierarchies, one of them based on a
completely positive representation of~K.
We illustrate this approach by computing bounds for
the quadratic shortest path problem, as well as
a maximum flow problem with pairwise arc-capacities.
Let $G$ be a directed acyclic graph with $n$ arcs, a source $s$ and a sink $t$. We introduce the cone $K$ of flow matrices, which is a polyhedral cone
generated by the matrices $1_P 1_P^T \in R^{n\times n}$, where
$1_P\in R^n$ is the incidence vector of the $(s,t)$-path $P$.
Several combinatorial problems reduce to a linear optimization problem over $K$.
This cone is intractable, but we provide two convergent approximation hierarchies, one of them based on a
completely positive representation of $K$.
We illustrate this approach by computing bounds for a maximum flow problem with pairwise arc-capacities.