Overview Statistic: PDF-Downloads (blue) and Frontdoor-Views (gray)
The search result changed since you submitted your search request. Documents might be displayed in a different sort order.
  • search hit 9 of 76
Back to Result List

A Mathematical Model for the Influence of Glucose-Insulin Dynamics on the Estrous Cycle in Dairy Cows

Please always quote using this URN: urn:nbn:de:0297-zib-73475
  • Nutrition plays a crucial role in regulating reproductive hormones and follicular development in cattle. This is visible particularly during the time of negative energy balance at the onset of milk production after calving. Here, elongated periods of anovulation have been observed, resulting from alterations in luteiniz- ing hormone concentrations, likely caused by lower glucose and insulin concen- trations in the blood. The mechanisms that result in a reduced fertility are not completely understood, although a close relationship to the glucose-insulin metabolism is widely supported. Following this idea, a mathematical model of the hormonal network combining reproductive hormones and hormones that are coupled to the glucose compartments within the body of the cow was developed. The model is built on ordinary differential equations and relies on previously introduced models on the bovine estrous cycle and the glucose-insulin dynam- ics. Necessary modifications and coupling mechanisms are thoroughly discussed. Depending on the composition and the amount of food, in particular the glu- cose content in the dry matter, the model quantifies reproductive hormones and follicular development over time. Simulation results for different nutritional regimes in lactating and non-lactating dairy cows are examined and compared with experimental studies. Regarding its applicability, this work is an early attempt towards developing in silico feeding strategies and may eventually help refining and reducing animal experiments.
Metadaten
Author:Mohamed Omari, Alexander Lange, Julia Plöntzke, Susanna RöblitzORCiD
Document Type:ZIB-Report
Date of first Publication:2019/06/11
Series (Serial Number):ZIB-Report (19-22)
ISSN:1438-0064
Accept ✔
Diese Webseite verwendet technisch erforderliche Session-Cookies. Durch die weitere Nutzung der Webseite stimmen Sie diesem zu. Unsere Datenschutzerklärung finden Sie hier.