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A pharmacokinetic-pharmacodynamic model for single dose administration of Dexamethasone in dairy cows

Please always quote using this URN: urn:nbn:de:0297-zib-75043
  • We present a mechanistic pharmacokinetic-pharmacodynamic model to simulate the effect of dexamethasone on the glucose metabolism in dairy cows. The coupling of the pharmacokinetic model to the pharmacodynamic model is based on mechanisms underlying homeostasis regulation by dexamethasone. In particular, the coupling takes into account the predominant role of dexamethasone in stimulating glucagon secretion, glycogenolysis and lipolysis and in impairing the sensitivity of cells to insulin. Simulating the effect of a single dose of dexamethasone on the physiological behaviour of the system shows that the adopted mechanisms are able to induce a temporary hyperglycemia and hyperinsulinemia, which captures the observed data in non-lactating cows. In lactating cows, the model simulations show that a single dose of dexamethasone reduces the lipolytic effect, owing to the reduction of glucose uptake by the mammary gland.
Author:Mohamed Omari, Julia Plöntzke, Susanna RöblitzORCiD
Document Type:ZIB-Report
Tag:systems biology; modelling; differential equations; metabolism; nutrition; bovine; fertility; reproduction; hormones; follicles; Dexamethasone; PK-PD
Date of first Publication:2019/11/12
Series (Serial Number):ZIB-Report (19-53)
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