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Combining in vitro simulation and in silico modelling towards a sophisticated human osteoarthritis model

  • Our project aimed at building an in silico model based on our recently developed in vitro osteoarthritis (OA) model seeking for refinement of the model to enhance validity and translatability towards the more sophisticated simulation of OA. In detail, the previously 3D in vitro model is based on 3D chondrogenic constructs generated solely from human bone marrow derived mesenchymal stromal cells (hMSCs). Besides studying the normal state of the model over 3 weeks, the in vitro model was treated with interleukin-1β (IL-1β) and tumor necrosis factor alpha (TNFα) to mimic an OA-like environment.

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Author:Annemarie Lang, Lisa Fischer, Marie-Christin Weber, Timo Gaber, Rainald Ehrig, Susanna RöblitzORCiD, Frank Buttgereit
Document Type:Article
Parent Title (English):Osteoarthritis and Cartilage
First Page:S183
Year of first publication:2019
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