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Computing Personalised Treatments through In Silico Clinical Trials. A Case Study on Downregulation in Assisted Reproduction

  • In Silico Clinical Trials (ISCT), i.e., clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine. In this paper we present a case study aiming at quantifying, by means of a multi-arm ISCT supervised by intelligent search, the potential impact of precision medicine approaches on a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction.

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Author:Toni Mancini, Federico Mari, Annalisa Massini, Igor Melatti, Ivano Salvo, Stefano Sinisi, Enrico Tronci, Rainald Ehrig, Susanna RöblitzORCiD, Brigitte Leeners
Document Type:In Proceedings
Parent Title (English):Experimental Evaluation of Algorithms for Solving Problems with Combinatorial Explosion, Workshop of the Federated Logic Conference 2018 (FLoC 2018), Oxford
First Page:1
Last Page:16
Date of first Publication:2018/08/10
Page Number:16
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