Influenza and other respiratory viruses: standardizing disease severity in surveillance and clinical trials

  • Introduction: Influenza-Like Illness is a leading cause of hospitalization in children. Disease burden due to influenza and other respiratory viral infections is reported on a population level, but clinical scores measuring individual changes in disease severity are urgently needed.   Areas covered: We present a composite clinical score allowing individual patient data analyses of disease severity based on systematic literature review and WHO-criteria for uncomplicated and complicated disease. The 22-item ViVI Disease Severity Score showed a normal distribution in a pediatric cohort of 6073 children aged 0-18 years (mean age 3.13; S.D. 3.89; range: 0 to 18.79).   Expert commentary: The ViVI Score was correlated with risk of antibiotic use, hospitalization and intensive care and was used to track children with influenza, respiratory syncytial virus, human metapneumovirus, human rhinovirus, and adenovirus infections and is fully compliant with regulatory data standards. The ViVI Disease Severity Score mobile application allows physicians to measure disease severity at the point-of care thereby taking clinical trials to the next level.

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Metadaten
Author:Tim Conrad, Barbara Rath, Puja Myles, Maren Alchikh, Xiaolin Ma, Christian Hoppe, Franziska Tief, Xi Chen, Patrick Obermeier, Bron Kisler, Brunhilde Schweiger
Document Type:Article
Parent Title (English):Expert Review of Anti-infective Therapy (IERZ)
Volume:16
Year of first publication:2017
DOI:http://dx.doi.org/10.1080/14787210.2017.1295847

$Rev: 13581 $