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Coupling of Monodomain and Eikonal Models for Cardiac Electrophysiology

  • The primary goal of this paper is to study the coupling of monodomain and eikonal models for the numerical simulation of cardiac electrophysiology. Eikonal models are nonlinear elliptic equations describing the excitation time of the cardiac tissue. They are often used as very fast approximations for monodomain or bidomain models - parabolic reaction-diffusion systems describing the excitation wavefront in terms of ionic currents. The excitation front is a thin region with high gradients, whereas excitation times vary over larger domains. Hence, eikonal equations can be solved on much coarser grids than monodomain equations. Moreover, as eikonal models are not time-dependent, no time integration is needed. Eikonal models are derived from monodomain models making additional assumptions and using certain approximations. While generally the approximation is rather good, several specific situations are not well captured by eikonal models. We consider coupling the two models, i.e. using the monodomain model in regions where more accurate results or the shape of the wavefront are needed, and the eikonal model in the remaining parts of the domain, where the excitation time is sufficient. Restricting the monodomain simulation to a small subdomain reduces the computational effort considerably. Numerical methods for the simulation of the individual models are presented, with the finite element method as the main ingredient. Coupling conditions as well as algorithms for implementing the coupling are explained. The approximation quality and efficiency of the coupled model is illustrated on simple geometries using an Aliev-Panfilov membrane model.
Author:Adrian Sali
Document Type:Master's Thesis
Granting Institution:Freie Universität Berlin
Advisor:Martin Weiser
Year of first publication:2016
Page Number:63
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