OVERLOAD of joints and its role in osteoarthritis - Towards understanding and preventing progression of primary osteoarthritis

  • Intact joints are necessary for skeletal function and mobility in daily life. A healthy musculoskeletal system is the basis for a functional cardiovascular system as well as an intact immune system. Locomotion, physiotherapy, and various forms of patient activity are essential clinical therapies used in the treatment of neurodegeneration, stroke, diabetes, and cancer. Mobility is substantially impaired with degeneration of joints and, in advanced stages, nighttime pain and sleep disturbance are particularly cumbersome. Osteoarthritis (OA) is also known as degenerative joint disease. OA involves structural and compositional changes in the articular cartilage, as well as in the calcified cartilage, subchondral cortical bone, subchondral cancellous bone, meniscus, joint capsular tissue, and synovium; which eventually lead to degeneration of these tissues comprising synovial joints.
Metadaten
Author:Bettina M. Willie, Thomas Pap, Carsten Perka, Carsten Oliver Schmidt, Felix Eckstein, Adamantios Arampatzis, Hans-Christian Hege, Henning Madry, Andrea Vortkamp, Georg N. Duda
Document Type:Article
Parent Title (English):Zeitschrift für Rheumatologie
Volume:74
First Page:618
Last Page:621
Year of first publication:2015
DOI:https://doi.org/10.1007/s00393-014-1561-2