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Optimization of Temperature Distributions for Regional Hyperthermia Based on a Nonlinear Heat Transfer Model

Please always quote using this URN: urn:nbn:de:0297-zib-3283
  • We describe an optimization process specially designed for regional hyperthermia of deap seated tumors in order to achieve desired steady--state temperature distributions. A nonlinear three--dimensional heat--transfer model based on temperature--dependent blood perfusion is applied to predict the temperature. Optimal heating is obtained by minimizing an integral object function which measures the distance between desired and model predicted temperatures. Sequential minima are calculated from successively improved constant--rate perfusion models employing a damped Newton method in an inner iteration. Numerical results for a Sigma 60 applicator are presented. This work has been supported by Deutsche Forschungsgemeinschaft (DFG) within the Sonderforschungsbereich 273 \glqq Hyperthermie: Methodik und Klinik \grqq .

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Author:Bodo Erdmann, Jens Lang, Martin Seebass
Document Type:ZIB-Report
Date of first Publication:1997/12/03
Series (Serial Number):ZIB-Report (SC-97-59)
Published in:Appeared in: Biotransport: Heat and Mass Transfer in Living Systems, K. Diller ed., 1998, Annals of the New York Academy of Sciences, 858 (1998), 36-46
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