Advances in modelling of the bovine estrous cycle: Administration of PGF2alpha

Please always quote using this URN: urn:nbn:de:0297-zib-12740
  • Our model of the bovine estrous cycle is a set of ordinary differential equations which generates hormone profiles of successive estrous cycles with several follicular waves per cycle. It describes the growth and decay of the follicles and the corpus luteum, as well as the change of the key substances over time. In this work we describe recent improvements of this model, including the introduction of new components, and elimination of time delays. We validate our model by showing that the simulations agree with observations from synchronization studies and with measured progesterone data after a single dose administration of synthetic prostaglandin F2alpha.

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Author:Claudia Stötzel, Julia Plöntzke, Susanna Röblitz
Document Type:ZIB-Report
Tag:cow; differential equations; hormone patterns; reproduction; systems biology
MSC-Classification:92-XX BIOLOGY AND OTHER NATURAL SCIENCES / 92Cxx Physiological, cellular and medical topics / 92C30 Physiology (general)
92-XX BIOLOGY AND OTHER NATURAL SCIENCES / 92Cxx Physiological, cellular and medical topics / 92C42 Systems biology, networks
92-XX BIOLOGY AND OTHER NATURAL SCIENCES / 92Cxx Physiological, cellular and medical topics / 92C50 Medical applications (general)
Date of first Publication:2011/06/14
Series (Serial Number):ZIB-Report (11-17)
Published in:Appeared in: Theriogenology 78 (2012), pp. 1415-1428

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