TY - JOUR A1 - Maher, Stephen J. A1 - Murray, John M. T1 - The unrooted set covering connected subgraph problem differentiating between HIV envelope sequences JF - European Journal of Operational Research N2 - This paper presents a novel application of operations research techniques to the analysis of HIV Env gene sequences, aiming to identify key features that are possible vaccine targets. These targets are identified as being critical to the transmission of HIV by being present in early transmitted (founder) sequences and absent in later chronic sequences. Identifying the key features of Env involves two steps: first, calculating the covariance of amino acid combinations and positions to form a network of related and compensatory mutations; and second, developing an integer program to identify the smallest connected subgraph of the constructed covariance network that exhibits a set covering property. The integer program developed for this analysis, labelled the unrooted set covering connected subgraph problem (USCCSP), integrates a set covering problem and connectivity evaluation, the latter formulated as a network flow problem. The resulting integer program is very large and complex, requiring the use of Benders' decomposition to develop an efficient solution approach. The results will demonstrate the necessity of applying acceleration techniques to the Benders' decomposition solution approach and the effectiveness of these techniques and heuristic approaches for solving the USCCSP. Y1 - 2016 U6 - https://doi.org/doi:10.1016/j.ejor.2015.07.011 VL - 248 IS - 2 SP - 668 EP - 680 ER - TY - CHAP A1 - Gamrath, Gerald A1 - Hiller, Benjamin A1 - Witzig, Jakob T1 - Reoptimization Techniques in MIP Solvers N2 - Recently, there have been many successful applications of optimization algorithms that solve a sequence of quite similar mixed-integer programs (MIPs) as subproblems. Traditionally, each problem in the sequence is solved from scratch. In this paper we consider reoptimization techniques that try to benefit from information obtained by solving previous problems of the sequence. We focus on the case that subsequent MIPs differ only in the objective function or that the feasible region is reduced. We propose extensions of the very complex branch-and-bound algorithms employed by general MIP solvers based on the idea to ``warmstart'' using the final search frontier of the preceding solver run. We extend the academic MIP solver SCIP by these techniques to obtain a reoptimizing branch-and-bound solver and report computational results which show the effectiveness of the approach. Y1 - 2015 SN - 978-3-319-20086-6 U6 - https://doi.org/10.1007/978-3-319-20086-6_14 VL - 9125 SP - 181 EP - 192 PB - Springer ET - Experimental Algorithms, Lecture Notes in Computer Science ER - TY - GEN A1 - Gamrath, Gerald A1 - Berthold, Timo A1 - Heinz, Stefan A1 - Winkler, Michael T1 - Structure-driven fix-and-propagate heuristics for mixed integer programming N2 - Primal heuristics play an important role in the solving of mixed integer programs (MIPs). They often provide good feasible solutions early in the solving process and help to solve instances to optimality faster. In this paper, we present a scheme for primal start heuristics that can be executed without previous knowledge of an LP solution or a previously found integer feasible solution. It uses global structures available within MIP solvers to iteratively fix integer variables and propagate these fixings. Thereby, fixings are determined based on the predicted impact they have on the subsequent domain propagation. If sufficiently many variables can be fixed that way, the resulting problem is solved as an LP and the solution is rounded. If the rounded solution did not provide a feasible solution already, a sub-MIP is solved for the neighborhood defined by the variable fixings performed in the first phase. The global structures help to define a neighborhood that is with high probability significantly easier to process while (hopefully) still containing good feasible solutions. We present three primal heuristics that use this scheme based on different global structures. Our computational experiments on standard MIP test sets show that the proposed heuristics find solutions for about three out of five instances and therewith help to improve several performance measures for MIP solvers, including the primal integral and the average solving time. T3 - ZIB-Report - 17-56 KW - mixed-integer programming KW - primal heuristics KW - fix-and-propagate KW - large neighborhood search KW - domain propagation Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-65387 SN - 1438-0064 ER - TY - GEN A1 - Berthold, Timo A1 - Hendel, Gregor A1 - Koch, Thorsten T1 - The Three Phases of MIP Solving N2 - Modern MIP solvers employ dozens of auxiliary algorithmic components to support the branch-and-bound search in finding and improving primal solutions and in strengthening the dual bound. Typically, all components are tuned to minimize the average running time to prove optimality. In this article, we take a different look at the run of a MIP solver. We argue that the solution process consists of three different phases, namely achieving feasibility, improving the incumbent solution, and proving optimality. We first show that the entire solving process can be improved by adapting the search strategy with respect to the phase-specific aims using different control tunings. Afterwards, we provide criteria to predict the transition between the individual phases and evaluate the performance impact of altering the algorithmic behavior of the MIP solver SCIP at the predicted phase transition points. T3 - ZIB-Report - 16-78 KW - optimization software KW - mixed-integer programming KW - branch-and-bound KW - adaptive search behavior KW - optimality prediction Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-61607 SN - 1438-0064 ER - TY - CHAP A1 - Schenker, Sebastian A1 - Vierhaus, Ingmar A1 - Borndörfer, Ralf A1 - Fügenschuh, Armin A1 - Skutella, Martin ED - Stark, Rainer ED - Seliger, Günther ED - Bonvoisin, Jérémy T1 - Optimisation Methods in Sustainable Manufacturing BT - Challenges, Solutions and Implementation Perspectives T2 - Sustainable Manufacturing N2 - Sustainable manufacturing is driven by the insight that the focus on the economic dimension in current businesses and lifestyles has to be broadened to cover all three pillars of sustainability: economic development, social development, and environmental protection. Y1 - 2017 SN - 978-3-319-48514-0 U6 - https://doi.org/10.1007/978-3-319-48514-0_15 SP - 239 EP - 253 PB - Springer International Publishing ER - TY - GEN A1 - Maher, Stephen J. A1 - Desaulniers, Guy A1 - Soumis, Francois T1 - The tail assignment problem with look-ahead maintenance constraints N2 - The tail assignment problem is a critical part of the airline planning process that assigns specific aircraft to sequences of flights, called lines-of-flight, to be operated the next day. The aim of this paper is to develop an operationally flexible tail assignment that satisfies short-range---within the next three days---aircraft maintenance requirements and performs the aircraft/flight gate assignment for each input line-of-flight. While maintenance plans commonly span multiple days, the related tail assignment problems can be overly complex and provide little recourse in the event of schedule perturbations. The presented approach addresses operational uncertainty by extending the one-day routes aircraft maintenance routing approach to satisfy maintenance requirements explicitly for the current day and implicitly for the subsequent two days. A mathematical model is presented that integrates the gate assignment and maintenance planning problems. To increase the satisfaction of maintenance requirements, an iterative algorithm is developed that modifies the fixed lines-of-flight provided as input to the tail assignment problem. The tail assignment problem and iterative algorithm are demonstrated to effectively satisfy maintenance requirements within appropriate run times using input data collected from three different airlines. T3 - ZIB-Report - 15-56 KW - Tail assignment KW - Column generation KW - Iterative algorithm Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-56717 SN - 1438-0064 ER - TY - JOUR A1 - Gamrath, Gerald A1 - Koch, Thorsten A1 - Martin, Alexander A1 - Miltenberger, Matthias A1 - Weninger, Dieter T1 - Progress in presolving for mixed integer programming JF - Mathematical Programming Computation N2 - This paper describes three presolving techniques for solving mixed integer programming problems (MIPs) that were implemented in the academic MIP solver SCIP. The task of presolving is to reduce the problem size and strengthen the formulation, mainly by eliminating redundant information and exploiting problem structures. The first method fixes continuous singleton columns and extends results known from duality fixing. The second analyzes and exploits pairwise dominance relations between variables, whereas the third detects isolated subproblems and solves them independently. The performance of the presented techniques is demonstrated on two MIP test sets. One contains all benchmark instances from the last three MIPLIB versions, while the other consists of real-world supply chain management problems. The computational results show that the combination of all three presolving techniques almost halves the solving time for the considered supply chain management problems. For the MIPLIB instances we obtain a speedup of 20 % on affected instances while not degrading the performance on the remaining problems. Y1 - 2015 U6 - https://doi.org/10.1007/s12532-015-0083-5 VL - 7 IS - 4 SP - 367 EP - 398 ER - TY - GEN A1 - Bestuzheva, Ksenia A1 - Besançon, Mathieu A1 - Chen, Wei-Kun A1 - Chmiela, Antonia A1 - Donkiewicz, Tim A1 - van Doornmalen, Jasper A1 - Eifler, Leon A1 - Gaul, Oliver A1 - Gamrath, Gerald A1 - Gleixner, Ambros A1 - Gottwald, Leona A1 - Graczyk, Christoph A1 - Halbig, Katrin A1 - Hoen, Alexander A1 - Hojny, Christopher A1 - van der Hulst, Rolf A1 - Koch, Thorsten A1 - Lübbecke, Marco A1 - Maher, Stephen J. A1 - Matter, Frederic A1 - Mühmer, Erik A1 - Müller, Benjamin A1 - Pfetsch, Marc E. A1 - Rehfeldt, Daniel A1 - Schlein, Steffan A1 - Schlösser, Franziska A1 - Serrano, Felipe A1 - Shinano, Yuji A1 - Sofranac, Boro A1 - Turner, Mark A1 - Vigerske, Stefan A1 - Wegscheider, Fabian A1 - Wellner, Philipp A1 - Weninger, Dieter A1 - Witzig, Jakob T1 - The SCIP Optimization Suite 8.0 N2 - The SCIP Optimization Suite provides a collection of software packages for mathematical optimization centered around the constraint integer programming framework SCIP. This paper discusses enhancements and extensions contained in version 8.0 of the SCIP Optimization Suite. Major updates in SCIP include improvements in symmetry handling and decomposition algorithms, new cutting planes, a new plugin type for cut selection, and a complete rework of the way nonlinear constraints are handled. Additionally, SCIP 8.0 now supports interfaces for Julia as well as Matlab. Further, UG now includes a unified framework to parallelize all solvers, a utility to analyze computational experiments has been added to GCG, dual solutions can be postsolved by PaPILO, new heuristics and presolving methods were added to SCIP-SDP, and additional problem classes and major performance improvements are available in SCIP-Jack. T3 - ZIB-Report - 21-41 KW - Constraint integer programming KW - Linear programming KW - Mixed-integer linear programming KW - Mixed-integer nonlinear programming KW - Optimization solver KW - Branch-and-cut KW - Branch-and-price KW - Column generation KW - Parallelization KW - Mixed-integer semidefinite programming Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-85309 SN - 1438-0064 ER - TY - GEN A1 - Bolusani, Suresh A1 - Besançon, Mathieu A1 - Bestuzheva, Ksenia A1 - Chmiela, Antonia A1 - Dionísio, João A1 - Donkiewicz, Tim A1 - van Doornmalen, Jasper A1 - Eifler, Leon A1 - Ghannam, Mohammed A1 - Gleixner, Ambros A1 - Graczyk, Christoph A1 - Halbig, Katrin A1 - Hedtke, Ivo A1 - Hoen, Alexander A1 - Hojny, Christopher A1 - van der Hulst, Rolf A1 - Kamp, Dominik A1 - Koch, Thorsten A1 - Kofler, Kevin A1 - Lentz, Jurgen A1 - Manns, Julian A1 - Mexi, Gioni A1 - Mühmer, Erik A1 - E. Pfetsch, Marc A1 - Schlösser, Franziska A1 - Serrano, Felipe A1 - Shinano, Yuji A1 - Turner, Mark A1 - Vigerske, Stefan A1 - Weninger, Dieter A1 - Xu, Liding T1 - The SCIP Optimization Suite 9.0 N2 - The SCIP Optimization Suite provides a collection of software packages for mathematical optimization, centered around the constraint integer programming framework SCIP. This report discusses the enhancements and extensions included in the SCIP Optimization Suite 9.0. The updates in SCIP 9.0 include improved symmetry handling, additions and improvements of nonlinear handlers and primal heuristics, a new cut generator and two new cut selection schemes, a new branching rule, a new LP interface, and several bug fixes. The SCIP Optimization Suite 9.0 also features new Rust and C++ interfaces for SCIP, new Python interface for SoPlex, along with enhancements to existing interfaces. The SCIP Optimization Suite 9.0 also includes new and improved features in the LP solver SoPlex, the presolving library PaPILO, the parallel framework UG, the decomposition framework GCG, and the SCIP extension SCIP-SDP. These additions and enhancements have resulted in an overall performance improvement of SCIP in terms of solving time, number of nodes in the branch-and-bound tree, as well as the reliability of the solver. T3 - ZIB-Report - 24-02-29 KW - Constraint integer programming KW - Linear programming KW - Mixed-integer linear programming KW - Mixed-integer nonlinear programming KW - Optimization solver KW - Branch-and-cut KW - Branch-and-price KW - Column generation KW - Parallelization KW - Mixed-integer semidefinite programming Y1 - 2024 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-95528 SN - 1438-0064 ER - TY - GEN A1 - Turner, Mark A1 - Chmiela, Antonia A1 - Koch, Thorsten A1 - Winkler, Michael T1 - PySCIPOpt-ML: Embedding Trained Machine Learning Models into Mixed-Integer Programs N2 - A standard tool for modelling real-world optimisation problems is mixed-integer programming (MIP). However, for many of these problems there is either incomplete information describing variable relations, or the relations between variables are highly complex. To overcome both these hurdles, machine learning (ML) models are often used and embedded in the MIP as surrogate models to represent these relations. Due to the large amount of available ML frameworks, formulating ML models into MIPs is highly non-trivial. In this paper we propose a tool for the automatic MIP formulation of trained ML models, allowing easy integration of ML constraints into MIPs. In addition, we introduce a library of MIP instances with embedded ML constraints. The project is available at https://github.com/Opt-Mucca/PySCIPOpt-ML. T3 - ZIB-Report - 23-28 Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-93095 SN - 1438-0064 ER - TY - JOUR A1 - Bestuzheva, Ksenia A1 - Besançon, Mathieu A1 - Chen, Wei-Kun A1 - Chmiela, Antonia A1 - Donkiewicz, Tim A1 - Doornmalen, Jasper A1 - Eifler, Leon A1 - Gaul, Oliver A1 - Gamrath, Gerald A1 - Gleixner, Ambros A1 - Gottwald, Leona A1 - Graczyk, Christoph A1 - Halbig, Katrin A1 - Hoen, Alexander A1 - Hojny, Christopher A1 - Hulst, Rolf A1 - Koch, Thorsten A1 - Lübbecke, Marco A1 - Maher, Stephen J. A1 - Matter, Frederic A1 - Mühmer, Erik A1 - Müller, Benjamin A1 - Pfetsch, Marc A1 - Rehfeldt, Daniel A1 - Schlein, Steffan A1 - Schlösser, Franziska A1 - Serrano, Felipe A1 - Shinano, Yuji A1 - Sofranac, Boro A1 - Turner, Mark A1 - Vigerske, Stefan A1 - Wegscheider, Fabian A1 - Wellner, Philipp A1 - Weninger, Dieter A1 - Witzig, Jakob T1 - Enabling research through the SCIP optimization suite 8.0 JF - ACM Transactions on Mathematical Software N2 - The SCIP Optimization Suite provides a collection of software packages for mathematical optimization centered around the constraint integer programming framework SCIP. The focus of this article is on the role of the SCIP Optimization Suite in supporting research. SCIP’s main design principles are discussed, followed by a presentation of the latest performance improvements and developments in version 8.0, which serve both as examples of SCIP’s application as a research tool and as a platform for further developments. Furthermore, this article gives an overview of interfaces to other programming and modeling languages, new features that expand the possibilities for user interaction with the framework, and the latest developments in several extensions built upon SCIP. Y1 - 2023 U6 - https://doi.org/10.1145/3585516 VL - 49 IS - 2 SP - 1 EP - 21 ER - TY - CHAP A1 - Turner, Mark A1 - Chmiela, Antonia A1 - Koch, Thorsten A1 - Winkler, Michael T1 - PySCIPOpt-ML: Embedding Trained Machine Learning Models into Mixed-Integer Programs T2 - Integration of Constraint Programming, Artificial Intelligence, and Operations Research. CPAIOR 2025 N2 - A standard tool for modelling real-world optimisation problems is mixed-integer programming (MIP). However, for many of these problems there is either incomplete information describing variable relations, or the relations between variables are highly complex. To overcome both these hurdles, machine learning (ML) models are often used and embedded in the MIP as surrogate models to represent these relations. Due to the large amount of available ML frameworks, formulating ML models into MIPs is highly non-trivial. In this paper we propose a tool for the automatic MIP formulation of trained ML models, allowing easy integration of ML constraints into MIPs. In addition, we introduce a library of MIP instances with embedded ML constraints. The project is available at https://github.com/Opt-Mucca/PySCIPOpt-ML. Y1 - 2025 U6 - https://doi.org/10.1007/978-3-031-95976-9_14 VL - 15763 ER - TY - JOUR A1 - Bestuzheva, Ksenia A1 - Chmiela, Antonia A1 - Müller, Benjamin A1 - Serrano, Felipe A1 - Vigerske, Stefan A1 - Wegscheider, Fabian T1 - Global Optimization of Mixed-Integer Nonlinear Programs with SCIP 8.0 JF - Journal of Global Optimization N2 - For over ten years, the constraint integer programming framework SCIP has been extended by capabilities for the solution of convex and nonconvex mixed-integer nonlinear programs (MINLPs). With the recently published version 8.0, these capabilities have been largely reworked and extended. This paper discusses the motivations for recent changes and provides an overview of features that are particular to MINLP solving in SCIP. Further, difficulties in benchmarking global MINLP solvers are discussed and a comparison with several state-of-the-art global MINLP solvers is provided. Y1 - 2023 U6 - https://doi.org/10.1007/s10898-023-01345-1 ER - TY - JOUR A1 - Chmiela, Antonia A1 - Muñoz, Gonzalo A1 - Serrano, Felipe T1 - Monoidal strengthening and unique lifting in MIQCPs JF - Mathematical Programming B Y1 - 2025 U6 - https://doi.org/10.1007/s10107-024-02112-0 VL - 210 SP - 189 EP - 222 ER -