TY - CHAP A1 - Taylor, William R. A1 - König, Christian A1 - Speirs, A. A1 - Ehrig, Rainald A1 - Duda, G. A1 - Heller, Markus O. T1 - The medio-lateral force distribution in the sheep knee during walking T2 - 5. World Congress of Biomechanics, Munich, Journal of Biomechanics Y1 - 2006 IS - 39, Suppl. 1 SP - S491 ER - TY - CHAP A1 - Taylor, William R. A1 - König, Christian A1 - Speirs, A. A1 - Ehrig, Rainald A1 - Duda, G. A1 - Heller, Markus O. T1 - Die medio-laterale Kraftverteilung im Schafsknie T2 - Deutscher Kongress für Orthpädie und Unfallchirurgie, Berlin Y1 - 2006 ER - TY - JOUR A1 - Kratzenstein, Stefan A1 - Kornaropoulos, Evgenios I. A1 - Ehrig, Rainald A1 - Heller, Markus O. A1 - Pöpplau, Berry M. A1 - Taylor, William R. T1 - Effective marker placement for functional identification of the centre of rotation at the hip JF - Gait & Posture Y1 - 2012 U6 - https://doi.org/http://dx.doi.org/10.1016/j.gaitpost.2012.04.011 VL - 36 IS - 3 SP - 482 EP - 486 ER - TY - CHAP A1 - Taylor, William R. A1 - Fröhlich, Annika A1 - Buttgereit, Frank A1 - Ehrig, Rainald A1 - Witaschek, Tom A1 - Duda, Georg ED - Kersting, Uwe ED - Morlock, Michael ED - Jirova-Enzmann, Daniela ED - Dremstrup, Kim T1 - Metacarpophalangeal joint stiffness is reduced in patients affected by rheumatoid arthritis after glucocorticoid medication T2 - Proceedings of the ESM-2012, Aalborg Y1 - 2012 SP - 39 PB - Department of Health Science and Technology, Aalborg University ER - TY - CHAP A1 - Kornaropoulos, Evgenios I. A1 - Taylor, William R. A1 - Duda, Georg A1 - Ehrig, Rainald A1 - Heller, Markus O. T1 - Frontal plane lower limb alignment using functionally determined joint centers and axes T2 - International Conference on Computational Bioengineering Y1 - 2009 ER - TY - CHAP A1 - Kornaropoulos, Evgenios I. A1 - Taylor, William R. A1 - Duda, Georg A1 - Ehrig, Rainald A1 - Heller, Markus O. T1 - An imageless method to quantify the Mechanical Femoral-Tibial Angle (MFTA) using functionally defined joint centers and axes. T2 - 6th Annual meeting of the German Society for Biomechanics (DGfB) Y1 - 2009 ER - TY - JOUR A1 - Trepczynski, Adam A1 - Kneifel, Paul A1 - Heyland, Mark A1 - Leskovar, Marko A1 - Moewis, Philippe A1 - Damm, Philipp A1 - Taylor, William R. A1 - Zachow, Stefan A1 - Duda, Georg N. T1 - Impact of the external knee flexion moment on patello-femoral loading derived from in vivo loads and kinematics JF - Frontiers in Bioengineering and Biotechnology N2 - Introduction: Anterior knee pain and other patello-femoral (PF) complications frequently limit the success of total knee arthroplasty as the final treatment of end stage osteoarthritis. However, knowledge about the in-vivo loading conditions at the PF joint remains limited, as no direct measurements are available. We hypothesised that the external knee flexion moment (EFM) is highly predictive of the PF contact forces during activities with substantial flexion of the loaded knee. Materials and methods: Six patients (65–80 years, 67–101 kg) with total knee arthroplasty (TKA) performed two activities of daily living: sit-stand-sit and squat. Tibio-femoral (TF) contact forces were measured in vivo using instrumented tibial components, while synchronously internal TF and PF kinematics were captured with mobile fluoroscopy. The measurements were used to compute PF contact forces using patient specific musculoskeletal models. The relationship between the EFM and the PF contact force was quantified using linear regression. Results: Mean peak TF contact forces of 1.97–3.24 times body weight (BW) were found while peak PF forces reached 1.75 to 3.29 times body weight (BW). The peak EFM ranged from 3.2 to 5.9 %BW times body height, and was a good predictor of the PF contact force (R2 = 0.95 and 0.88 for sit-stand-sit and squat, respectively). Discussion: The novel combination of in vivo TF contact forces and internal patellar kinematics enabled a reliable assessment of PF contact forces. The results of the regression analysis suggest that PF forces can be estimated based solely on the EFM from quantitative gait analysis. Our study also demonstrates the relevance of PF contact forces, which reach magnitudes similar to TF forces during activities of daily living. Y1 - 2024 U6 - https://doi.org/10.3389/fbioe.2024.1473951 SN - 2296-4185 VL - 12/2024 PB - Frontiers Media SA ER - TY - JOUR A1 - Heller, Markus O. A1 - Matziolis, Georg A1 - König, Christian A1 - Taylor, William R. A1 - Hinterwimmer, S. A1 - Graichen, H. A1 - Hege, Hans-Christian A1 - Bergmann, G. A1 - Perka, Carsten A1 - Duda, G. N. T1 - Muskuloskelettale Biomechanik des Kniegelenks - Grundlagen für die präoperative Planung von Umstellung und Gelenkersatz JF - Der Orthopäde Y1 - 2007 U6 - https://doi.org/10.1007/s00132-007-1115-2 VL - 36 IS - 7 SP - 628 EP - 634 ER - TY - JOUR A1 - Boeth, Heide A1 - Duda, Georg A1 - Hinzmann, Daniel A1 - Hermann, Sandra A1 - Taylor, William R. A1 - Ehrig, Rainald A1 - Witaschek, Tom A1 - Buttgereit, Frank T1 - A Novel Approach to Quantify Morning Stiffness in Patients with Rheumatoid Arthritis JF - Annual European Congress of Rheumatology, EULAR 2015, Rome Y1 - 2015 ER - TY - CHAP A1 - Boeth, Heide A1 - Duda, Georg A1 - Hinzmann, Daniel A1 - Taylor, William R. A1 - Ehrig, Rainald A1 - Witaschek, Tom A1 - Buttgereit, Frank T1 - Objektive Quantifizierung der Morgensteifigkeit als Parameter für rheumatoide Arthritis im Metacarpophalangealgelenk T2 - 9. Jahrestagung der Deutschen Gesellschaft für Biomechanik (DGfB), Bonn Y1 - 2015 ER - TY - JOUR A1 - Boeth, Heide A1 - Biesen, Robert A1 - Hollnagel, Jeremias A1 - Herrmann, Sandra A1 - Ehrig, Rainald A1 - Pelli, Lorenzo A1 - Taylor, William R. A1 - Duda, Georg A1 - Buttgereit, Frank T1 - Quantification of morning stiffness to assess disease activity and treatment effects in rheumatoid arthritis JF - Rheumatology N2 - Objectives The clinical parameter “morning stiffness” is widely used to assess the status of rheumatoid arthritis (RA), but its accurate quantitative assessment in a clinical setting has not yet been successful. This lack of individual quantification limits both personalized medication and efficacy evaluation in the treatment of RA. Methods We have developed a novel technology to assess passive resistance of the metacarpophalangeal (MCP) III joint (stiffness) and its Passive Range of Motion (PRoM). Within this pilot study, nineteen female postmenopausal RA patients and nine healthy controls were examined in the evening as well as in the morning of the following day. To verify the specificity of the biomechanical quantification, eleven patients with RA were assessed both prior to and ∼3 h after glucocorticoid therapy. Results While the healthy controls showed only minor changes between afternoon and morning, in RA patients mean±SD PRoM decreased significantly by 18 ± 22% and stiffness increased significantly by 20 ± 18% in the morning compared with the previous afternoon. We found a significant positive correlation between RA activity and biomechanical measures. Glucocorticoids significantly increased mean PRoM by 16 ± 11% and reduced mean stiffness by 23 ± 22%. Conclusion This technology allowed mechanical stiffness to be quantified in MCP joints, and has demonstrated high sensitivity in respect to disease status as well as medication effect in RA patients. Such non-invasive, low risk, and rapid assessment of biomechanical joint stiffness opens a novel avenue for judging therapy efficacy in patients with RA, and potentially also in other non-RA inflammatory joint diseases. Y1 - 2021 U6 - https://doi.org/10.1093/rheumatology/keab323 VL - 60 IS - 11 SP - 5282 EP - 5291 ER - TY - JOUR A1 - Trepczynski, Adam A1 - Kneifel, Paul A1 - Heyland, Mark A1 - Leskovar, Marko A1 - Moewis, Philippe A1 - Damm, Philipp A1 - Taylor, William R. A1 - Zachow, Stefan A1 - Duda, Georg T1 - Impact of the External Knee Flexion Moment on Patello-Femoral Loading Derived from in vivo Loads and Kinematics JF - Frontiers in Bioengineering and Biotechnology N2 - Anterior knee pain and other patello-femoral (PF) complications frequently limit the success of total knee arthroplasty as the final treatment of end stage osteoarthritis. However, knowledge about the invivo loading conditions at the PF joint remains limited, as no direct measurements are available. We hypothesised that the external knee flexion moment (EFM) is highly predictive of the PF contact forces during activities with substantial flexion of the loaded knee.Six patients (65-80 years, 67-101 kg) with total knee arthroplasty (TKA) performed two activities of daily living: sit-stand-sit and squat. Tibio-femoral (TF) contact forces were measured in vivo using instrumented tibial components, while synchronously internal TF and PF kinematics were captured with mobile fluoroscopy. The measurements were used to compute PF contact forces using patient specific musculoskeletal models. The relationship between the EFM and the PF contact force was quantified using linear regression.Mean peak TF contact forces of 1.97 to 3.24 times body weight (BW) were found while peak PF forces reached 1.75 to 3.29 times body weight (BW). The peak EFM ranged from 3.2 to 5.9 %BW times body height, and was a good predictor of the PF contact force (R^2 = 0.95 and 0.88 for sit-standsit and squat, respectively).The novel combination of in vivo TF contact forces and internal patellar kinematics enabled a reliable assessment of PF contact forces. The results of the regression analysis suggest that PF forces can be estimated based solely on the EFM from quantitative gait analysis. Our study also demonstrates the relevance of PF contact forces, which reach magnitudes similar to TF forces during activities of daily living. Y1 - 2024 U6 - https://doi.org/10.3389/fbioe.2024.1473951 VL - 12 ER -