TY - JOUR A1 - Schulz, Robert A1 - Yamamoto, Kenji A1 - Klossek, André A1 - Rancan, Fiorenza A1 - Vogt, Annika A1 - Schütte, Christof A1 - Rühl, Eckart A1 - Netz, Roland R. T1 - Modeling of Drug Diffusion Based on Concentration Profiles in Healthy and Damaged Human Skin JF - Biophysical Journal N2 - Based on experimental drug concentration profiles in healthy as well as tape-stripped ex vivo human skin, we model the penetration of the antiinflammatory drug dexamethasone into the skin layers by the one-dimensional generalized diffusion equation. We estimate the position-dependent free-energy and diffusivity profiles by solving the conjugated minimization problem, in which the only inputs are concentration profiles of dexamethasone in skin at three consecutive penetration times. The resulting free-energy profiles for damaged and healthy skin show only minor differences. In contrast, the drug diffusivity in the first 10 μm of the upper skin layer of damaged skin is 200-fold increased compared to healthy skin, which reflects the corrupted barrier function of tape-stripped skin. For the case of healthy skin, we examine the robustness of our method by analyzing the behavior of the extracted skin parameters when the number of input and output parameters are reduced. We also discuss techniques for the regularization of our parameter extraction method. Y1 - 2019 U6 - https://doi.org/10.1016/j.bpj.2019.07.027 VL - 117 IS - 5 SP - 998 EP - 1008 ER - TY - CHAP A1 - Grimm, Boris A1 - Borndörfer, Ralf A1 - Schulz, Christof A1 - Weider, Steffen T1 - The Rolling Stock Rotation Planning Problem under Revenue Considerations T2 - Proceedings of the Rail Transport Demand Management Conference N2 - In many railway undertakings a railway timetable is offered that is valid for a longer period of time. At DB Fernverkehr AG, one of our industrial partners, this results in a summer and a winter timetable. For both of these timetables rotation plans, i.e., a detailed plan of railway vehicle movements is constructed as a template for this period. Sometimes there are be periods where you know for sure that vehicle capacities are not sufficient to cover all trips of the timetable or to transport all passenger of the trips. Reasons for that could be a heavy increase of passenger flow, a heavy decrease of vehicle availability, impacts from nature, or even strikes of some employees. In such events the rolling stock rotations have to be adapted. Optimization methods are particularly valuable in such situations in order to maintain a best possible level of service or to maximize the expected revenue using the resources that are still available. In most cases found in the literature, a rescheduling based on a timetable update is done, followed by the construction of new rotations that reward the recovery of parts of the obsolete rotations. We consider a different, novel, and more integrated approach. The idea is to guide the cancellation of the trips or reconfiguration of the vehicle composition used to operate a trip of the timetable by the rotation planning process, which is based on the mixed integer programming approach presented in Reuther (2017). The goal is to minimize the operating costs while cancelling or operating a trip with an insufficient vehicle configuration in sense of passenger capacities inflicts opportunity costs and loss of revenue, which are based on an estimation of the expected number of passengers. The performance of the algorithms presented in two case studies, including real world scenarios from DB Fernverkehr AG and a railway operator in North America. Y1 - 2018 ER - TY - GEN A1 - Grimm, Boris A1 - Borndörfer, Ralf A1 - Schulz, Christof A1 - Weider, Steffen T1 - The Rolling Stock Rotation Planning Problem under Revenue Considerations N2 - In many railway undertakings a railway timetable is offered that is valid for a longer period of time. At DB Fernverkehr AG, one of our industrial partners, this results in a summer and a winter timetable. For both of these timetables rotation plans, i.e., a detailed plan of railway vehicle movements is constructed as a template for this period. Sometimes there are be periods where you know for sure that vehicle capacities are not sufficient to cover all trips of the timetable or to transport all passenger of the trips. Reasons for that could be a heavy increase of passenger flow, a heavy decrease of vehicle availability, impacts from nature, or even strikes of some employees. In such events the rolling stock rotations have to be adapted. Optimization methods are particularly valuable in such situations in order to maintain a best possible level of service or to maximize the expected revenue using the resources that are still available. In most cases found in the literature, a rescheduling based on a timetable update is done, followed by the construction of new rotations that reward the recovery of parts of the obsolete rotations. We consider a different, novel, and more integrated approach. The idea is to guide the cancellation of the trips or reconfiguration of the vehicle composition used to operate a trip of the timetable by the rotation planning process, which is based on the mixed integer programming approach presented in Reuther (2017). The goal is to minimize the operating costs while cancelling or operating a trip with an insufficient vehicle configuration in sense of passenger capacities inflicts opportunity costs and loss of revenue, which are based on an estimation of the expected number of passengers. The performance of the algorithms presented in two case studies, including real world scenarios from DB Fernverkehr AG and a railway operator in North America. T3 - ZIB-Report - 19-01 Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-71339 SN - 1438-0064 ER - TY - GEN A1 - Schlechte, Thomas A1 - Blome, Christian A1 - Gerber, Stefan A1 - Hauser, Stefan A1 - Kasten, Jens A1 - Müller, Gilbert A1 - Schulz, Christof A1 - Thüring, Michel A1 - Weider, Steffen T1 - The Bouquet of Features in Rolling Stock Rotation Planning T2 - Conference Proceedings RailBelgrade 2023 N2 - Rolling stock is one of the major assets for a railway transportation company. Hence, their utilization should be as efficiently and effectively as possible. Railway undertakings are facing rolling stock scheduling challenges in different forms - from rather idealized weekly strategic problems to very concrete operational ones. Thus, a vast of optimization models with different features and objectives exist. Thorlacius et al. (2015) provides a comprehensive and valuable collection on technical requirements, models, and methods considered in the scientific literature. We contribute with an update including recent works. The main focus of the paper is to present a classification and elaboration of the major features which our solver R-OPT is able to handle. Moreover, the basic optimization model and algorithmic ingredients of R-OPT are discussed. Finally, we present computational results for a cargo application at SBB CARGO AG and other railway undertakings for passenger traffic in Europe to show the capabilities of R-OPT. Y1 - 2023 UR - https://easychair.org/publications/preprint/Nms6 ER - TY - JOUR A1 - Breugem, Thomas A1 - Schlechte, Thomas A1 - Schulz, Christof A1 - Borndörfer, Ralf T1 - A three-phase heuristic for the Fairness-Oriented Crew Rostering Problem JF - Computers & Operations Research N2 - The Fairness-Oriented Crew Rostering Problem (FCRP) considers the joint optimization of attractiveness and fairness in cyclic crew rostering. Like many problems in scheduling and logistics, the combinatorial complexity of cyclic rostering causes exact methods to fail for large-scale practical instances. In case of the FCRP, this is accentuated by the additionally imposed fairness requirements. Hence, heuristic methods are necessary. We present a three-phase heuristic for the FCRP combining column generation techniques with variable-depth neighborhood search. The heuristic exploits different mathematical formulations to find feasible solutions and to search for improvements. We apply our methodology to practical instances from Netherlands Railways (NS), the main passenger railway operator in the Netherlands Our results show the three-phase heuristic finds good solutions for most instances and outperforms a state-of-the-art commercial solver. Y1 - 2023 U6 - https://doi.org/https://doi.org/10.1016/j.cor.2023.106186 VL - 154 ER -