TY - CHAP A1 - Taylor, William R. A1 - Kassi, J.-P. A1 - Schwarzkopf, J. A1 - Ehrig, Rainald A1 - Schell, H. A1 - Duda, G. T1 - The Profile of Mechanical Loading is Independent of Fracture Fixation Principle T2 - Proceedings of the 51th Annual Meeting of the Orthopedic Society Y1 - 2005 CY - Washington ER - TY - JOUR A1 - Taylor, William R. A1 - Pöpplau, Berry M. A1 - König, Christian A1 - Ehrig, Rainald A1 - Zachow, Stefan A1 - Duda, Georg A1 - Heller, Markus O. T1 - The medial-lateral force distribution in the ovine stifle joint during walking JF - Journal of Orthopaedic Research Y1 - 2011 U6 - https://doi.org/10.1002/jor.21254 VL - 29 IS - 4 SP - 567 EP - 571 ER - TY - JOUR A1 - Boeth, Heide A1 - Duda, Georg A1 - Heller, Markus O. A1 - Ehrig, Rainald A1 - Doyscher, Ralf A1 - Jung, Tobias A1 - Moewis, Philippe A1 - Scheffler, Sven A1 - Taylor, William R. T1 - Anterior cruciate ligament-deficient patients with passive knee joint laxity have a decreased range of anterior-posterior motion during active movements JF - The American Journal of Sports Medicine Y1 - 2013 U6 - https://doi.org/10.1177/0363546513480465 VL - 41 IS - 5 SP - 1051 EP - 7 ER - TY - CHAP A1 - Taylor, William R. A1 - Ehrig, Rainald A1 - Duda, G. A1 - Heller, Markus O. T1 - The Symmetrical Axis of Rotation Approach (SARA) for Determination of Joint Axes in Clinical Gait Analysis T2 - 1st Joint ESMAC-GCMAS Meeting, Amsterdam Y1 - 2006 ER - TY - CHAP A1 - Taylor, William R. A1 - Ehrig, Rainald A1 - Heller, Markus O. A1 - Schell, H. A1 - Duda, G. T1 - Can Skin Markers Determine the Kinematics of Underlying Bones? T2 - Proceedings of the 50th Annual Meeting of the Orthopedic Society Y1 - 2004 CY - San Francisco ER - TY - JOUR A1 - Taylor, William R. A1 - Ehrig, Rainald A1 - Heller, Markus O. A1 - Schell, H. A1 - Klein, P. A1 - Duda, G. T1 - On the Influence of Soft Tissue Coverage in the Determination of Bone Kinematics using Bone Markers JF - Journal of Orthopedic Research Y1 - 2005 IS - 23 SP - 726 EP - 734 ER - TY - CHAP A1 - Taylor, William R. A1 - Ehrig, Rainald A1 - Heller, Markus O. A1 - Schell, H. A1 - Seebeck, P. A1 - Duda, G. T1 - Animal Models for Knee Injury Frequently Underestimate the Mechanical Conditions of the Clinical Situation T2 - Proceedings of the 51th Annual Meeting of the Orthopedic Society Y1 - 2005 CY - Washington ER - TY - JOUR A1 - Taylor, William R. A1 - Ehrig, Rainald A1 - Heller, Markus O. A1 - Schell, H. A1 - Seebeck, P. A1 - Duda, G. T1 - Tibio-femoral Joint Contact Forces in Sheep JF - Journal of Biomechanics Y1 - 2006 IS - 39 SP - 791 EP - 798 ER - TY - CHAP A1 - Taylor, William R. A1 - Kornaropoulos, Evgenios I. A1 - Ehrig, Rainald A1 - Heller, Markus O. A1 - Duda, Georg T1 - Reproducibility of a functional approach to gait analysis T2 - Annual meeting of the ESMAC 2009 Y1 - 2009 CY - London ER - TY - CHAP A1 - Taylor, William R. A1 - Kratzenstein, Stefan A1 - Kornaropoulos, Evgenios I. A1 - Ehrig, Rainald A1 - Moewis, Philippe A1 - Heller, Markus O. T1 - Non-invasive Assessment of Skeletal Kinematics T2 - Measurement and Sensing in Medicine and Health Y1 - 2009 CY - London ER - TY - CHAP A1 - Taylor, William R. A1 - Kornaropoulos, Evgenios I. A1 - Kratzenstein, Stefan A1 - Ehrig, Rainald A1 - Plank, F. A1 - Heller, Markus O. T1 - Targeted Marker Placement for the Functional Identification of the Hip Joint Centre T2 - Transactions Vol. 36, 2011 Annual Meeting of the Orthopedic Society Y1 - 2011 CY - Long Beach ER - TY - CHAP A1 - Taylor, William R. A1 - König, Christian A1 - Speirs, A. A1 - Ehrig, Rainald A1 - Duda, G. A1 - Heller, Markus O. T1 - The medio-lateral force distribution in the sheep knee during walking T2 - 5. World Congress of Biomechanics, Munich, Journal of Biomechanics Y1 - 2006 IS - 39, Suppl. 1 SP - S491 ER - TY - CHAP A1 - Taylor, William R. A1 - König, Christian A1 - Speirs, A. A1 - Ehrig, Rainald A1 - Duda, G. A1 - Heller, Markus O. T1 - Die medio-laterale Kraftverteilung im Schafsknie T2 - Deutscher Kongress für Orthpädie und Unfallchirurgie, Berlin Y1 - 2006 ER - TY - JOUR A1 - Kratzenstein, Stefan A1 - Kornaropoulos, Evgenios I. A1 - Ehrig, Rainald A1 - Heller, Markus O. A1 - Pöpplau, Berry M. A1 - Taylor, William R. T1 - Effective marker placement for functional identification of the centre of rotation at the hip JF - Gait & Posture Y1 - 2012 U6 - https://doi.org/http://dx.doi.org/10.1016/j.gaitpost.2012.04.011 VL - 36 IS - 3 SP - 482 EP - 486 ER - TY - CHAP A1 - Taylor, William R. A1 - Fröhlich, Annika A1 - Buttgereit, Frank A1 - Ehrig, Rainald A1 - Witaschek, Tom A1 - Duda, Georg ED - Kersting, Uwe ED - Morlock, Michael ED - Jirova-Enzmann, Daniela ED - Dremstrup, Kim T1 - Metacarpophalangeal joint stiffness is reduced in patients affected by rheumatoid arthritis after glucocorticoid medication T2 - Proceedings of the ESM-2012, Aalborg Y1 - 2012 SP - 39 PB - Department of Health Science and Technology, Aalborg University ER - TY - CHAP A1 - Kornaropoulos, Evgenios I. A1 - Taylor, William R. A1 - Duda, Georg A1 - Ehrig, Rainald A1 - Heller, Markus O. T1 - Frontal plane lower limb alignment using functionally determined joint centers and axes T2 - International Conference on Computational Bioengineering Y1 - 2009 ER - TY - CHAP A1 - Kornaropoulos, Evgenios I. A1 - Taylor, William R. A1 - Duda, Georg A1 - Ehrig, Rainald A1 - Heller, Markus O. T1 - An imageless method to quantify the Mechanical Femoral-Tibial Angle (MFTA) using functionally defined joint centers and axes. T2 - 6th Annual meeting of the German Society for Biomechanics (DGfB) Y1 - 2009 ER - TY - JOUR A1 - Weber, Marie-Christin A1 - Fischer, Lisa A1 - Damerau, Alexandra A1 - Ponomarev, Igor A1 - Pfeiffenberger, Moritz A1 - Gaber, Timo A1 - Götschel, Sebastian A1 - Lang, Jens A1 - Röblitz, Susanna A1 - Buttgereit, Frank A1 - Ehrig, Rainald A1 - Lang, Annemarie T1 - Macroscale mesenchymal condensation to study cytokine-driven cellular and matrix-related changes during cartilage degradation JF - Biofabrication N2 - Understanding the pathophysiological processes of cartilage degradation requires adequate model systems to develop therapeutic strategies towards osteoarthritis (OA). Although different in vitro or in vivo models have been described, further comprehensive approaches are needed to study specific disease aspects. This study aimed to combine in vitro and in silico modeling based on a tissue-engineering approach using mesenchymal condensation to mimic cytokine-induced cellular and matrix-related changes during cartilage degradation. Thus, scaffold-free cartilage-like constructs (SFCCs) were produced based on self-organization of mesenchymal stromal cells (mesenchymal condensation) and i) characterized regarding their cellular and matrix composition or secondly ii) treated with interleukin-1β (IL-1β) and tumor necrosis factor α (TNFα) for 3 weeks to simulate OA-related matrix degradation. In addition, an existing mathematical model based on partial differential equations was optimized and transferred to the underlying settings to simulate distribution of IL-1β, type II collagen degradation and cell number reduction. By combining in vitro and in silico methods, we aim to develop a valid, efficient alternative approach to examine and predict disease progression and effects of new therapeutics. Y1 - 2020 U6 - https://doi.org/10.1088/1758-5090/aba08f VL - 12 IS - 4 ER - TY - JOUR A1 - Alves, Sónia A1 - Ehrig, Rainald A1 - Raffalt, Peter C. A1 - Bender, Alwina A1 - Duda, Georg A1 - Agres, Alison N. T1 - Quantifying Asymmetry in Gait: A Weighted Universal Symmetry Index to Evaluate 3D Ground Reaction Forces JF - Frontiers in Bioengineering and Biotechnology N2 - Though gait asymmetry is used as a metric of functional recovery in clinical rehabilitation, there is no consensus on an ideal method for its evaluation. Various methods have been proposed but are limited in scope, as they can often use only positive signals or discrete values extracted from time-scale data as input. By defining five symmetry axioms, a framework for benchmarking existing methods was established and a new method was described here for the first time: the weighted universal symmetry index (wUSI), which overcomes limitations of other methods. Both existing methods and the wUSI were mathematically compared to each other and in respect to their ability to fulfill the proposed symmetry axioms. Eligible methods that fulfilled these axioms were then applied using both discrete and continuous approaches to ground reaction force (GRF) data collected from healthy gait, both with and without artificially induced asymmetry using a single instrumented elbow crutch. The wUSI with a continuous approach was the only symmetry method capable of determining GRF asymmetries in different walking conditions in all three planes of motion. When used with a continuous approach, the wUSI method was able to detect asymmetries while avoiding artificial inflation, a common problem reported in other methods. In conclusion, the wUSI is proposed as a universal method to quantify three-dimensional GRF asymmetries, which may also be expanded to other biomechanical signals. Y1 - 2020 ER - TY - JOUR A1 - Fischer, Sophie A1 - Ehrig, Rainald A1 - Schäfer, Stefan A1 - Tronci, Enrico A1 - Mancini, Toni A1 - Egli, Marcel A1 - Ille, Fabian A1 - Krüger, Tillmann H. C. A1 - Leeners, Brigitte A1 - Röblitz, Susanna T1 - Mathematical Modelling and Simulation Provides Evidence for New Strategies of Ovarian Stimulation JF - Frontiers in Endocrinology N2 - New approaches to ovarian stimulation protocols, such as luteal start, random start or double stimulation, allow for flexibility in ovarian stimulation at different phases of the menstrual cycle which is especially useful when time for assisted reproductive technology is limited, e.g. for emergency fertility preservation in cancer patients. It has been proposed that the success of these methods is based on the continuous growth of multiple cohorts ("waves") of follicles throughout the menstrual cycle which leads to the availability of ovarian follicles for ovarian controlled stimulation at several time points. Though several preliminary studies have been published, their scientific evidence has not been considered as being strong enough to integrate these results into routine clinical practice. This work aims at adding further scientific evidence about the efficiency of variable-start protocols and underpinning the theory of follicular waves by using mathematical modelling and numerical simulations. For this purpose, we have modified and coupled two previously published models, one describing the time course of hormones and one describing competitive follicular growth in a normal menstrual cycle. The coupled model is used to test stimulation protocols in silico. Simulation results show the occurrence of follicles in a wave-like manner during a normal menstrual cycle and qualitatively predict the outcome of ovarian stimulation initiated at different time points of the menstrual cycle. Y1 - 2021 U6 - https://doi.org/10.3389/fendo.2021.613048 VL - 12 ER -