TY - JOUR A1 - Moewis, Philippe A1 - Boeth, Heide A1 - Heller, Markus O. A1 - Yntema, Caroline A1 - Jung, Tobias A1 - Doyscher, Ralf A1 - Ehrig, Rainald A1 - Zhong, Yanlin A1 - Taylor, William R. T1 - Towards understanding knee joint laxity: Errors in non-invasive assessment of joint rotation can be corrected JF - Medical Engineering and Physics Y1 - 2014 U6 - https://doi.org/doi.org/10.1016/j.medengphy.2014.03.017 VL - 36 IS - 7 SP - 889 EP - 895 ER - TY - JOUR A1 - Gupta, Pooja A1 - Peter, Sarah A1 - Jung, Markus A1 - Lewin, Astrid A1 - Hemmrich-Stanisak, Georg A1 - Franke, Andre A1 - von Kleist, Max A1 - Schütte, Christof A1 - Einspanier, Ralf A1 - Sharbati, Soroush A1 - zur Bruegge, Jennifer T1 - Analysis of long non-coding RNA and mRNA expression in bovine macrophages brings up novel 2 aspects of Mycobacterium avium subspecies paratuberculosis infections JF - Scientific Reports in Nature N2 - Paratuberculosis is a major disease in cattle that severely affects animal welfare and causes huge economic losses worldwide. Development of alternative diagnostic methods is of urgent need to control the disease. Recent studies suggest that long non-coding RNAs (lncRNAs) play a crucial role in regulating immune function and may confer valuable information about the disease. However, their role has not yet been investigated in cattle with respect to infection towards Paratuberculosis. Therefore, we investigated the alteration in genomic expression profiles of mRNA and lncRNA in bovine macrophages in response to Paratuberculosis infection using RNA-Seq. We identified 397 potentially novel lncRNA candidates in macrophages of which 38 were differentially regulated by the infection. A total of 820 coding genes were also significantly altered by the infection. Co-expression analysis of lncRNAs and their neighbouring coding genes suggest regulatory functions of lncRNAs in pathways related to immune response. For example, this included protein coding genes such as TNIP3, TNFAIP3 and NF-κB2 that play a role in NF-κB2 signalling, a pathway associated with immune response. This study advances our understanding of lncRNA roles during Paratuberculosis infection. Y1 - 2019 U6 - https://doi.org/10.1038/s41598-018-38141-x VL - 9 ER - TY - JOUR A1 - Boeth, Heide A1 - Duda, Georg A1 - Heller, Markus O. A1 - Ehrig, Rainald A1 - Doyscher, Ralf A1 - Jung, Tobias A1 - Moewis, Philippe A1 - Scheffler, Sven A1 - Taylor, William R. T1 - Anterior cruciate ligament-deficient patients with passive knee joint laxity have a decreased range of anterior-posterior motion during active movements JF - The American Journal of Sports Medicine Y1 - 2013 U6 - https://doi.org/10.1177/0363546513480465 VL - 41 IS - 5 SP - 1051 EP - 7 ER -