TY - GEN A1 - Plöntzke, Julia A1 - Berg, Mascha A1 - Stötzel, Claudia A1 - Röblitz, Susanna T1 - A systems biology approach to bovine fertility and metabolism: Development of a glucose insulin model. N2 - To counteract the antagonistic relationship between milk yield and fertility in dairy cow, a deeper understanding of the underlying biological mechanisms is required. For this purpose, we study physiological networks related to reproduction and metabolism in dairy cows. We interactively develop dynamic, mechanistic models by fitting the models to experimental data and mechanistic knowledge. We have already developed models for potassium balance and hormonal regulation of fertility in the dairy cow, which will briefly be reviewed here. The main focus of this article is a glucose-insulin model currently developed by us. This model links the bovine hormonal cycle and the potassium balance to glucose and thus to energy metabolism. The models can be applied in scientific research, education, experimental planning, drug development and production on farms. T3 - ZIB-Report - 15-51 Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-56453 SN - 1438-0064 ER - TY - CHAP A1 - Plöntzke, Julia A1 - Berg, Mascha A1 - Stötzel, Claudia A1 - Röblitz, Susanna T1 - A systems biology approach to bovine fertility and metabolism: Introduction of a glucose insulin model T2 - 15th International Symposium on Mathematical and Computational Biology, Rorkee, India Y1 - 2015 ER - TY - GEN A1 - Stötzel, Claudia A1 - Plöntzke, Julia A1 - Röblitz, Susanna T1 - Advances in modelling of the bovine estrous cycle: Administration of PGF2alpha N2 - Our model of the bovine estrous cycle is a set of ordinary differential equations which generates hormone profiles of successive estrous cycles with several follicular waves per cycle. It describes the growth and decay of the follicles and the corpus luteum, as well as the change of the key substances over time. In this work we describe recent improvements of this model, including the introduction of new components, and elimination of time delays. We validate our model by showing that the simulations agree with observations from synchronization studies and with measured progesterone data after a single dose administration of synthetic prostaglandin F2alpha. T3 - ZIB-Report - 11-17 KW - cow KW - reproduction KW - hormone patterns KW - differential equations KW - systems biology Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-12740 ER - TY - JOUR A1 - Stötzel, Claudia A1 - Plöntzke, Julia A1 - Heuwieser, Wolfgang A1 - Röblitz, Susanna T1 - Advances in modelling of the bovine estrous cycle: Synchronization with PGF2alpha JF - Theriogenology Y1 - 2012 U6 - https://doi.org/10.1016/j.theriogenology.2012.04.017 VL - 78 SP - 1415 EP - 1428 ER - TY - JOUR A1 - Stötzel, Claudia A1 - Ehrig, Rainald A1 - Boer, H. Marike T. A1 - Plöntzke, Julia A1 - Röblitz, Susanna T1 - Exploration of different wave patterns in a model of the bovine estrous cycle by Fourier analysis JF - BIOMAT - Proceedings of the 14th International Symposium on Mathematical and Computational Biology, Bedlewo, Poland N2 - Cows typically have different numbers of follicular waves during their hormonal cycle. Understanding the underlying regulations leads to insights into the reasons for declined fertility, a phenomenon that has been observed during the last decades. We present a systematic approach based on Fourier analysis to examine how parameter changes in a model of the bovine estrous cycle lead to different wave patterns. Even without any biological considerations, this allows to detect the responsible model parameters that control the type of periodicity of the solution, thus supporting experimental planning of animal scientists. Y1 - 2014 ER - TY - GEN A1 - Stötzel, Claudia A1 - Ehrig, Rainald A1 - Boer, H. Marike T. A1 - Plöntzke, Julia A1 - Röblitz, Susanna T1 - Exploration of different wave patterns in a model of the bovine estrous cycle by Fourier analysis N2 - Cows typically have different numbers of follicular waves during their hormonal cycle. Understanding the underlying regulations leads to insights into the reasons for declined fertility, a phenomenon that has been observed during the last decades. We present a systematic approach based on Fourier analysis to examine how parameter changes in a model of the bovine estrous cycle lead to different wave patterns. Even without any biological considerations, this allows to detect the responsible model parameters that control the type of periodicity of the solution, thus supporting experimental planning of animal scientists. T3 - ZIB-Report - 16-02 Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-57039 SN - 1438-0064 ER -