TY - JOUR A1 - Oberlaender, Marcel A1 - de Kock, Christiaan P. J. A1 - Bruno, Randy M. A1 - Ramirez, Alejandro A1 - Meyer, Hanno A1 - Dercksen, Vincent J. A1 - Helmstaedter, Moritz A1 - Sakmann, Bert T1 - Cell Type-Specific Three-Dimensional Structure of Thalamocortical Circuits in a Column of Rat Vibrissal Cortex JF - Cerebral Cortex Y1 - 2012 U6 - https://doi.org/doi:10.1093/cercor/bhr317 VL - 22 IS - 10 SP - 2375 EP - 2391 ER - TY - GEN A1 - Oberlaender, Marcel A1 - Bruno, Randy M. A1 - de Kock, Christiaan P. J. A1 - Meyer, Hanno A1 - Dercksen, Vincent J. A1 - Sakmann, Bert T1 - 3D distribution and sub-cellular organization of thalamocortical VPM synapses for individual excitatory neuronal cell types in rat barrel cortex T2 - Conference Abstract No. 173.19/Y35, 39th Annual Meeting of the Society for Neuroscience (SfN) Y1 - 2009 ER - TY - GEN A1 - Oberlaender, Marcel A1 - Dercksen, Vincent J. A1 - Broser, Philip J. A1 - Bruno, Randy M. A1 - Sakmann, Bert T1 - NeuroMorph and NeuroCount: Automated tools for fast and objective acquisition of neuronal morphology for quantitative structural analysis T2 - Frontiers in Neuroinformatics. Conference Abstract: Neuroinformatics Y1 - 2008 U6 - https://doi.org/10.3389/conf.neuro.11.2008.01.065 ER - TY - GEN A1 - Egger, Robert A1 - Dercksen, Vincent J. A1 - Kock, Christiaan P.J. A1 - Oberlaender, Marcel ED - Cuntz, Hermann ED - Remme, Michiel W.H. ED - Torben-Nielsen, Benjamin T1 - Reverse Engineering the 3D Structure and Sensory-Evoked Signal Flow of Rat Vibrissal Cortex T2 - The Computing Dendrite Y1 - 2014 U6 - https://doi.org/10.1007/978-1-4614-8094-5_8 VL - 11 SP - 127 EP - 145 PB - Springer CY - New York ER - TY - JOUR A1 - Egger, Robert A1 - Dercksen, Vincent J. A1 - Udvary, Daniel A1 - Hege, Hans-Christian A1 - Oberlaender, Marcel T1 - Generation of dense statistical connectomes from sparse morphological data JF - Frontiers in Neuroanatomy Y1 - 2014 U6 - https://doi.org/10.3389/fnana.2014.00129 VL - 8 IS - 129 ER - TY - JOUR A1 - Lang, Stefan A1 - Dercksen, Vincent J. A1 - Sakmann, Bert A1 - Oberlaender, Marcel T1 - Simulation of signal flow in 3D reconstructions of an anatomically realistic neural network in rat vibrissal cortex JF - Neural Networks Y1 - 2011 U6 - https://doi.org/doi:10.1016/j.neunet.2011.06.013 VL - 24 IS - 9 SP - 998 EP - 1011 ER - TY - GEN A1 - Dercksen, Vincent J. A1 - Oberlaender, Marcel A1 - Sakmann, Bert A1 - Hege, Hans-Christian T1 - Light Microscopy-Based Reconstruction and Interactive Structural Analysis of Cortical Neural Networks T2 - BioVis 2011 Abstracts, 1st IEEE Symposium on Biological Data Visualization Y1 - 2011 ER - TY - CHAP A1 - Dercksen, Vincent J. A1 - Egger, Robert A1 - Hege, Hans-Christian A1 - Oberlaender, Marcel T1 - Synaptic Connectivity in Anatomically Realistic Neural Networks: Modeling and Visual Analysis T2 - Eurographics Workshop on Visual Computing for Biology and Medicine (VCBM) Y1 - 2012 U6 - https://doi.org/10.2312/VCBM/VCBM12/017-024 SP - 17 EP - 24 CY - Norrköping, Sweden ER - TY - GEN A1 - Pfister, Hanspeter A1 - Kaynig, Verena A1 - Botha, Charl A1 - Bruckner, Stefan A1 - Dercksen, Vincent J. A1 - Hege, Hans-Christian A1 - Roerdink, Jos T1 - Visualization in Connectomics Y1 - 2012 U6 - https://doi.org/10.1007/978-1-4471-6497-5_21 ER - TY - JOUR A1 - Kuß, Anja A1 - Gensel, Maria A1 - Meyer, Björn A1 - Dercksen, Vincent J. A1 - Prohaska, Steffen T1 - Effective Techniques to Visualize Filament-Surface Relationships JF - Comput. Graph. Forum Y1 - 2010 VL - 29 SP - 1003 EP - 1012 ER - TY - JOUR A1 - Oberlaender, Marcel A1 - Dercksen, Vincent J. A1 - Egger, Robert A1 - Gensel, Maria A1 - Sakmann, Bert A1 - Hege, Hans-Christian T1 - Automated three-dimensional detection and counting of neuron somata JF - Journal of Neuroscience Methods Y1 - 2009 U6 - https://doi.org/10.1016/j.jneumeth.2009.03.008 VL - 180 IS - 1 SP - 147 EP - 160 ER - TY - GEN A1 - Oberlaender, Marcel A1 - Dercksen, Vincent J. A1 - Lang, Stefan A1 - Sakmann, Bert T1 - 3D mapping of synaptic connections within “in silico” microcircuits of full compartmental neurons in extended networks on the example of VPM axons projecting into S1 of rats. T2 - Conference Abstract, Neuroinformatics Y1 - 2009 U6 - https://doi.org/10.3389/conf.neuro.11.2009.08.092 ER - TY - CHAP A1 - Homberg, Ulrike A1 - Binner, Richard A1 - Prohaska, Steffen A1 - Dercksen, Vincent J. A1 - Kuß, Anja A1 - Kalbe, Ute T1 - Determining Geometric Grain Structure from X-Ray Micro-Tomograms of Gradated Soil T2 - Workshop Internal Erosion Y1 - 2009 VL - 21 SP - 37 EP - 52 ER - TY - JOUR A1 - Landau, Itamar D. A1 - Egger, Robert A1 - Dercksen, Vincent J. A1 - Oberlaender, Marcel A1 - Sompolinsky, Haim T1 - The Impact of Structural Heterogeneity on Excitation-Inhibition Balance in Cortical Networks JF - Neuron N2 - Models of cortical dynamics often assume a homogeneous connectivity structure. However, we show that heterogeneous input connectivity can prevent the dynamic balance between excitation and inhibition, a hallmark of cortical dynamics, and yield unrealistically sparse and temporally regular firing. Anatomically based estimates of the connectivity of layer 4 (L4) rat barrel cortex and numerical simulations of this circuit indicate that the local network possesses substantial heterogeneity in input connectivity, sufficient to disrupt excitation-inhibition balance. We show that homeostatic plasticity in inhibitory synapses can align the functional connectivity to compensate for structural heterogeneity. Alternatively, spike-frequency adaptation can give rise to a novel state in which local firing rates adjust dynamically so that adaptation currents and synaptic inputs are balanced. This theory is supported by simulations of L4 barrel cortex during spontaneous and stimulus-evoked conditions. Our study shows how synaptic and cellular mechanisms yield fluctuation-driven dynamics despite structural heterogeneity in cortical circuits. Y1 - 2016 U6 - https://doi.org/10.1016/j.neuron.2016.10.027 VL - 92 IS - 5 SP - 1106 EP - 1121 ER - TY - JOUR A1 - Dercksen, Vincent J. A1 - Hege, Hans-Christian A1 - Oberlaender, Marcel T1 - The Filament Editor: An Interactive Software Environment for Visualization, Proof-Editing and Analysis of 3D Neuron Morphology JF - NeuroInformatics Y1 - 2014 U6 - https://doi.org/10.1007/s12021-013-9213-2 VL - 12 IS - 2 SP - 325 EP - 339 PB - Springer US ER - TY - CHAP A1 - Papazov, Chavdar A1 - Dercksen, Vincent J. A1 - Lamecker, Hans A1 - Hege, Hans-Christian T1 - Visualizing morphogenesis and growth by temporal interpolation of surface-based 3D atlases T2 - Proceedings of the 2008 IEEE International Symposium on Biomedical Imaging Y1 - 2008 U6 - https://doi.org/10.1109/ISBI.2008.4541123 SP - 824 EP - 827 ER - TY - CHAP A1 - Dercksen, Vincent J. A1 - Weber, Britta A1 - Günther, David A1 - Oberlaender, Marcel A1 - Prohaska, Steffen A1 - Hege, Hans-Christian T1 - Automatic alignment of stacks of filament data T2 - Proc. IEEE International Symposium on Biomedical Imaging Y1 - 2009 SP - 971 EP - 974 PB - IEEE press CY - Boston, USA ER - TY - GEN A1 - Dercksen, Vincent J. A1 - Gensel, Maria A1 - Kuß, Anja T1 - Visual Accentuation of Spatial Relationships between Filamentous and Voluminous Surface Structures T2 - Conference Abstract, Eurographics / IEEE Symposium on Visualization Y1 - 2009 ER - TY - CHAP A1 - Dercksen, Vincent J. A1 - Brüß, Cornelia A1 - Stalling, Detlev A1 - Gubatz, Sabine A1 - Seiffert, Udo A1 - Hege, Hans-Christian T1 - Towards automatic generation of 3D models of biological objects based on serial sections T2 - Visualization in Medicine and Life Sciences Y1 - 2008 U6 - https://doi.org/10.1007/978-3-540-72630-2 SP - 3 EP - 25 PB - Springer-Verlag Berlin Heidelberg ER - TY - CHAP A1 - Dercksen, Vincent J. A1 - Prohaska, Steffen A1 - Hege, Hans-Christian T1 - Fast cross-sectional display of large data sets T2 - IAPR Conference on Machine Vision Applications Y1 - 2005 SP - 336 EP - 339 CY - Tsukuba, Japan ER -