TY - JOUR A1 - Sontheimer, Tobias A1 - Rudigier-Voigt, Eveline A1 - Bockmeyer, Matthias A1 - Lockau, Daniel A1 - Klimm, Carola A1 - Becker, Christiane A1 - Rech, Bernd T1 - Light harvesting architectures for electron beam evaporated solid phase crystallized Si thin film solar cells JF - Journal of Non-Crystalline Solids Y1 - 2012 U6 - https://doi.org/10.1016/j.jnoncrysol.2011.10.025 VL - 358 IS - 17 SP - 2303 EP - 2307 ER - TY - JOUR A1 - Becker, Christiane A1 - Amkreutz, Daniel A1 - Sontheimer, Tobias A1 - Preidel, Veit A1 - Lockau, Daniel A1 - Haschke, Jan A1 - Jogschies, Lisa A1 - Klimm, Carola A1 - Merkel, Janis J. A1 - Plocica, Paul A1 - Steffens, Simon A1 - Rech, Bernd T1 - Polycrystalline silicon thin-film solar cells: Status and perspectives JF - Solar Energy Materials and Solar Cells Y1 - 2013 U6 - https://doi.org/10.1016/j.solmat.2013.05.043 VL - 119 SP - 112 EP - 123 ER - TY - JOUR A1 - Haase, Tobias A1 - Sunkara, Vikram A1 - Kohl, Benjamin A1 - Meier, Carola A1 - Bußmann, Patricia A1 - Becker, Jessica A1 - Jagielski, Michal A1 - von Kleist, Max A1 - Ertel, Wolfgang T1 - Discerning the spatio-temporal disease patterns of surgically induced OA mouse models JF - PLOS One N2 - Osteoarthritis (OA) is the most common cause of disability in ageing societies, with no effective therapies available to date. Two preclinical models are widely used to validate novel OA interventions (MCL-MM and DMM). Our aim is to discern disease dynamics in these models to provide a clear timeline in which various pathological changes occur. OA was surgically induced in mice by destabilisation of the medial meniscus. Analysis of OA progression revealed that the intensity and duration of chondrocyte loss and cartilage lesion formation were significantly different in MCL-MM vs DMM. Firstly, apoptosis was seen prior to week two and was narrowly restricted to the weight bearing area. Four weeks post injury the magnitude of apoptosis led to a 40–60% reduction of chondrocytes in the non-calcified zone. Secondly, the progression of cell loss preceded the structural changes of the cartilage spatio-temporally. Lastly, while proteoglycan loss was similar in both models, collagen type II degradation only occurred more prominently in MCL-MM. Dynamics of chondrocyte loss and lesion formation in preclinical models has important implications for validating new therapeutic strategies. Our work could be helpful in assessing the feasibility and expected response of the DMM- and the MCL-MM models to chondrocyte mediated therapies. Y1 - 2019 U6 - https://doi.org/10.1371/journal.pone.0213734 VL - 14 IS - 4 PB - PLOS One ER - TY - GEN A1 - Knötel, David A1 - Becker, Carola A1 - Scholtz, Gerhard A1 - Baum, Daniel T1 - Global and Local Mesh Morphing for Complex Biological Objects from microCT Data N2 - We show how biologically coherent mesh models of animals can be created from μCT data to generate artificial yet naturally looking intermediate objects. The whole pipeline of processing algorithms is presented, starting from generating topologically equivalent surface meshes, followed by solving the correspondence problem, and, finally, creating a surface morphing. In this pipeline, we address all the challenges that are due to dealing with complex biological, non-isometric objects. For biological objects it is often particularly important to obtain deformations that look as realistic as possible. In addition, spatially non-uniform shape morphings that only change one part of the surface and keep the rest as stable as possible are of interest for evolutionary studies, since functional modules often change independently from one another. We use Poisson interpolation for this purpose and show that it is well suited to generate both global and local shape deformations. T3 - ZIB-Report - 18-53 KW - Mesh interpolation KW - Geometry processing KW - microCT Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-70618 SN - 1438-0064 ER - TY - CHAP A1 - Knötel, David A1 - Becker, Carola A1 - Scholtz, Gerhard A1 - Baum, Daniel T1 - Global and Local Mesh Morphing for Complex Biological Objects from microCT Data T2 - Eurographics Workshop on Visual Computing for Biology and Medicine (VCBM) N2 - We show how biologically coherent mesh models of animals can be created from μCT data to generate artificial yet naturally looking intermediate objects. The whole pipeline of processing algorithms is presented, starting from generating topologically equivalent surface meshes, followed by solving the correspondence problem, and, finally, creating a surface morphing. In this pipeline, we address all the challenges that are due to dealing with complex biological, non-isometric objects. For biological objects it is often particularly important to obtain deformations that look as realistic as possible. In addition, spatially non-uniform shape morphings that only change one part of the surface and keep the rest as stable as possible are of interest for evolutionary studies, since functional modules often change independently from one another. We use Poisson interpolation for this purpose and show that it is well suited to generate both global and local shape deformations. Y1 - 2018 U6 - https://doi.org/10.2312/vcbm.20181243 SP - 179 EP - 183 CY - Granada, Spain ER -