TY - JOUR A1 - Lange, Alexander T1 - Reconstruction of disease transmission rates: applications to measles, dengue, and influenza JF - Journal of Theoretical Biology Y1 - 2016 U6 - https://doi.org/10.1016/j.jtbi.2016.04.017 VL - 400 SP - 138 EP - 153 ER - TY - JOUR A1 - Bauer, Gernot A1 - Gribova, Nadezhda A1 - Lange, Alexander A1 - Holm, Christian A1 - Gross, Joachim T1 - Three-body effects in triplets of capped gold nanocrystals JF - Molecular Physics Y1 - 2017 U6 - https://doi.org/10.1080/00268976.2016.1213909 VL - 115 SP - 1031 EP - 1040 ER - TY - CHAP A1 - Lange, Alexander A1 - Plöntzke, Julia A1 - Schäfer, Stefan A1 - Röblitz, Susanna T1 - Follicular maturation in cows: mathematical models and data T2 - 10. European Conference on Mathematical and Theoretical Biology Y1 - 2016 ER - TY - CHAP A1 - Lange, Alexander T1 - A mathematical framework for predicting lifestyles of viral pathogens T2 - Modelling Biological Evolution 2017: Developing Novel Approaches Y1 - 2017 ER - TY - GEN A1 - Lange, Alexander A1 - Schwieger, Robert A1 - Plöntzke, Julia A1 - Schäfer, Stefan A1 - Röblitz, Susanna T1 - Follicular competition: the selection of dominant follicles as a synergistic effect N2 - The estrous cycle of mono-ovulatory species such as cows or humans, is known to show two or more waves of follicular growth and decline between two successive ovulations. Within each wave, there is one dominant follicle escorted by subordinate follicles of varying number. Under the surge of the luteinizing hormone a growing dominant follicle ovulates. Rarely the number of ovulating follicles exceeds one. In the biological literature, the change of hormonal concentrations and individually varying numbers of follicular receptors are made responsible for the selection of exactly one dominant follicle, yet a clear cause has not been identified. In this paper, we suggest a synergistic explanation based on competition, formulated by a parsimoniously defined system of ordinary differential equations (ODEs) that quantifies the time evolution of multiple follicles and their competitive interaction during one wave. Not discriminating between follicles, growth and decline are given by fixed rates. Competition is introduced via a growth-suppressing term, equally supported by all follicles. We prove that the number of dominant follicles is determined exclusively by the ratio of follicular growth and competition. This number turns out to be independent of the number of subordinate follicles. The asymptotic behavior of the corresponding dynamical system is investigated rigorously, where we demonstrate that the omega-limit set only contains fixed points. When also including follicular decline, our ODEs perfectly resemble ultrasound data of bovine follicles. Implications for the involved but not explicitly modeled hormones are discussed. T3 - ZIB-Report - 17-21 Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-63863 SN - 1438-0064 ER - TY - JOUR A1 - Omari, Mohamed A1 - Lange, Alexander A1 - Plöntzke, Julia A1 - Röblitz, Susanna T1 - Model-based exploration of the impact of glucose metabolism on the estrous cycle dynamics in dairy cows JF - Biology Direct Y1 - 2019 U6 - https://doi.org/10.1186/s13062-019-0256-7 VL - 15 ER - TY - GEN A1 - Omari, Mohamed A1 - Lange, Alexander A1 - Plöntzke, Julia A1 - Röblitz, Susanna T1 - A Mathematical Model for the Influence of Glucose-Insulin Dynamics on the Estrous Cycle in Dairy Cows N2 - Nutrition plays a crucial role in regulating reproductive hormones and follicular development in cattle. This is visible particularly during the time of negative energy balance at the onset of milk production after calving. Here, elongated periods of anovulation have been observed, resulting from alterations in luteiniz- ing hormone concentrations, likely caused by lower glucose and insulin concen- trations in the blood. The mechanisms that result in a reduced fertility are not completely understood, although a close relationship to the glucose-insulin metabolism is widely supported. Following this idea, a mathematical model of the hormonal network combining reproductive hormones and hormones that are coupled to the glucose compartments within the body of the cow was developed. The model is built on ordinary differential equations and relies on previously introduced models on the bovine estrous cycle and the glucose-insulin dynam- ics. Necessary modifications and coupling mechanisms are thoroughly discussed. Depending on the composition and the amount of food, in particular the glu- cose content in the dry matter, the model quantifies reproductive hormones and follicular development over time. Simulation results for different nutritional regimes in lactating and non-lactating dairy cows are examined and compared with experimental studies. Regarding its applicability, this work is an early attempt towards developing in silico feeding strategies and may eventually help refining and reducing animal experiments. T3 - ZIB-Report - 19-22 Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-73475 SN - 1438-0064 ER - TY - JOUR A1 - Lange, Alexander A1 - Schwieger, Robert A1 - Plöntzke, Julia A1 - Schäfer, Stefan A1 - Röblitz, Susanna T1 - Follicular competition in cows: the selection of dominant follicles as a synergistic effect JF - Journal of Mathematical Biology N2 - The reproductive cycle of mono-ovulatory species such as cows or humans is known to show two or more waves of follicular growth and decline between two successive ovulations. Within each wave, there is one dominant follicle escorted by subordinate follicles of varying number. Under the surge of the luteinizing hormone a growing dominant follicle ovulates. Rarely the number of ovulating follicles exceeds one. In the biological literature, the change of hormonal concentrations and individually varying numbers of follicular receptors are made responsible for the selection of exactly one dominant follicle, yet a clear cause has not been identified. In this paper, we suggest a synergistic explanation based on competition, formulated by a parsimoniously defined system of ordinary differential equations (ODEs) that quantifies the time evolution of multiple follicles and their competitive interaction during one wave. Not discriminating between follicles, growth and decline are given by fixed rates. Competition is introduced via a growth-suppressing term, equally supported by all follicles. We prove that the number of dominant follicles is determined exclusively by the ratio of follicular growth and competition. This number turns out to be independent of the number of subordinate follicles. The asymptotic behavior of the corresponding dynamical system is investigated rigorously, where we demonstrate that the ω-limit set only contains fixed points. When also including follicular decline, our ODEs perfectly resemble ultrasound data of bovine follicles. Implications for the involved but not explicitly modeled hormones are discussed. Y1 - 2018 U6 - https://doi.org/https://doi.org/10.1007/s00285-018-1284-0 ER -