TY - JOUR A1 - Goubergrits, Leonid A1 - Hellmeier, Florian A1 - Bruening, Jan Joris A1 - Spuler, Andreas A1 - Hege, Hans-Christian A1 - Voss, Samuel A1 - Janiga, Gábor A1 - Saalfeld, Sylvia A1 - Beuing, Oliver A1 - Berg, Philipp T1 - Multiple Aneurysms AnaTomy CHallenge 2018 (MATCH): Uncertainty Quantification of Geometric Rupture Risk Parameters JF - BioMedical Engineering OnLine N2 - Background Geometric parameters have been proposed for prediction of cerebral aneurysm rupture risk. Predicting the rupture risk for incidentally detected unruptured aneurysms could help clinicians in their treatment decision. However, assessment of geometric parameters depends on several factors, including the spatial resolution of the imaging modality used and the chosen reconstruction procedure. The aim of this study was to investigate the uncertainty of a variety of previously proposed geometric parameters for rupture risk assessment, caused by variability of reconstruction procedures. Materials 26 research groups provided segmentations and surface reconstructions of five cerebral aneurysms as part of the Multiple Aneurysms AnaTomy CHallenge (MATCH) 2018. 40 dimensional and non-dimensional geometric parameters, describing aneurysm size, neck size, and irregularity of aneurysm shape, were computed. The medians as well as the absolute and relative uncertainties of the parameters were calculated. Additionally, linear regression analysis was performed on the absolute uncertainties and the median parameter values. Results A large variability of relative uncertainties in the range between 3.9 and 179.8% was found. Linear regression analysis indicates that some parameters capture similar geometric aspects. The lowest uncertainties < 6% were found for the non-dimensional parameters isoperimetric ratio, convexity ratio, and ellipticity index. Uncertainty of 2D and 3D size parameters was significantly higher than uncertainty of 1D parameters. The most extreme uncertainties > 80% were found for some curvature parameters. Conclusions Uncertainty analysis is essential on the road to clinical translation and use of rupture risk prediction models. Uncertainty quantification of geometric rupture risk parameters provided by this study may help support development of future rupture risk prediction models. Y1 - 2019 U6 - https://doi.org/10.1186/s12938-019-0657-y VL - 18 IS - 35 ER - TY - CHAP A1 - Goubergrits, Leonid A1 - Pöthke, Jens A1 - Petz, Christoph A1 - Hege, Hans-Christian A1 - Spuler, Andreas A1 - Kertzscher, Ulrich T1 - 3D Bildgebung von zerebralen Aneurysmen T2 - Bildverarbeitung für die Medizin Y1 - 2008 U6 - https://doi.org/10.1007/978-3-540-78640-5_31 SP - 153 EP - 157 ER - TY - JOUR A1 - Goubergrits, Leonid A1 - Schaller, Jens A1 - Kertzscher, Ulrich A1 - Petz, Christoph A1 - Hege, Hans-Christian A1 - Spuler, Andreas T1 - Reproducibility of Image-Based Analysis of Cerebral Aneurysm Geometry and Hemodynamics: An In-Vitro Study of Magnetic Resonance Imaging, Computed Tomography, and Three-Dimensional Rotational Angiography JF - Journal of Neurological Surgery, Part A: Central European Neurosurgery Y1 - 2013 U6 - https://doi.org/10.1055/s-0033-1342937 VL - 74 IS - 5 SP - 294 EP - 302 ER - TY - JOUR A1 - Goubergrits, Leonid A1 - Schaller, Jens A1 - Kertzscher, Ulrich A1 - van den Bruck, Nils A1 - Pöthkow, Kai A1 - Petz, Christoph A1 - Hege, Hans-Christian A1 - Spuler, Andreas T1 - Statistical wall shear stress maps of ruptured and unruptured middle cerebral artery aneurysms JF - J. R. Soc. Interface Y1 - 2012 U6 - https://doi.org/10.1098/rsif.2011.0490 VL - 9 IS - 69 SP - 677 EP - 688 ER - TY - JOUR A1 - Goubergrits, Leonid A1 - Spuler, Andreas A1 - Schaller, Jens A1 - Wiegmann, Nils A1 - Berthe, Andre A1 - Hege, Hans-Christian A1 - Affeld, Klaus A1 - Kertzscher, Ulrich T1 - In vitro study of hemodynamic treatment improvement: Hunterian ligation of a fenestrated basilar artery aneurysm after coiling JF - The International Journal of Artificial Organs N2 - Hunterian ligation affecting hemodynamics in vessels was proposed to avoid rebleeding in a case of a fenestrated basilar artery aneurysm after incomplete coil occlusion. We studied the hemodynamics in vitro to predict the hemodynamic changes near the aneurysm remnant caused by Hunterian ligation. A transparent model was fabricated based on three-dimensional rotational angiography imaging. Arteries were segmented and reconstructed. Pulsatile flow in the artery segments near the partially occluded (coiled) aneurysm was investigated by means of particle image velocimetry. The hemodynamic situation was investigated before and after Hunterian ligation of either the left or the right vertebral artery (LVA/RVA). Since post-ligation flow rate in the basilar artery was unknown, reduced and retained flow rates were simulated for both ligation options. Flow in the RVA and in the corresponding fenestra vessel is characterized by a vortex at the vertebrobasilar junction, whereas the LVA exhibits undisturbed laminar flow. Both options (RVA or LVA ligation) cause a significant flow reduction near the aneurysm remnant with a retained flow rate. The impact of RVA ligation is, however, significantly higher. This in vitro case study shows that flow reduction near the aneurysm remnant can be achieved by Hunterian ligation and that this effect depends largely on the selection of the ligated vessel. Thus the ability of the proposed in vitro pipe-line to improve hemodynamic impact of the proposed therapy was successfully proved. Y1 - 2014 U6 - https://doi.org/10.5301/ijao.5000314 VL - 37 IS - 4 SP - 325 EP - 335 ER - TY - JOUR A1 - Goubergrits, Leonid A1 - Thamsen, Bente A1 - Berthe, André A1 - Poethke, Jens A1 - Kertzscher, Ulrich A1 - Affeld, Klaus A1 - Petz, Christoph A1 - Hege, Hans-Christian A1 - Hoch, Heinrich A1 - Spuler, Andreas T1 - In Vitro Study of Near-Wall Flow in a Cerebral Aneurysm Model with and without Coils JF - American Journal of Neuroradiology Y1 - 2010 U6 - https://doi.org/10.3174/ajnr.A2121 VL - 31:8 SP - 1521 EP - 1528 ER - TY - JOUR A1 - Goubergrits, Leonid A1 - Weber, Sarah A1 - Petz, Christoph A1 - Spuler, Andreas A1 - Pöthke, Jens A1 - Berthe, André A1 - Hege, Hans-Christian T1 - Wall-PIV as a Near Wall Flow Validation Tool for CFD JF - Journal of Visualization Y1 - 2009 VL - 12 IS - 3 SP - 241 EP - 250 ER - TY - CHAP A1 - Petz, Christoph A1 - Stalling, Detlev A1 - Goubergrits, Leonid A1 - Affeld, Klaus A1 - Spuler, Andreas ED - Tolxdorff, Thomas T1 - Validierung von Strömungssimulationen in kardiovaskulären Anwendungen T2 - Bildverabeitung für die Medizin 2004 Y1 - 2004 SP - 356 EP - 360 ER - TY - CHAP A1 - Poethke, Jens A1 - Goubergrits, Leonid A1 - Kertzscher, Ulrich A1 - Spuler, Andreas A1 - Petz, Christoph A1 - Hege, Hans-Christian ED - Jos Vander Sloten, Pascal ED - Haueisen, Jens T1 - Impact of imaging modality for analysis of a cerebral aneurysm: Comparison between CT, MRI and 3DRA T2 - Proceedings of the 4th European Conference of the International Federation for Medical and Biological Engineering Y1 - 2008 U6 - https://doi.org/10.1007/978-3-540-89208-3 SP - 1889 EP - 1893 PB - Springer-Verlag CY - Antwerp, Belgium ER -