TY - GEN A1 - Deuflhard, Peter A1 - Hege, Hans-Christian A1 - Seebass, Martin T1 - Progress Towards a Combined MRI/Hyperthermia System N2 - Regional hyperthermia, a clinical cancer therapy, is the main topic of the Sonderforschungsbereich Hyperthermia: Scientific Methods and Clinical Applications'' at Berlin. In recent years, technological improvements towards a better concentration of heat to the desired target region have been achieved. These include a rather sophisticated integrated software environment for therapy planning and a new hyperthermia applicator. In a next step, a detailed closed loop monitoring of the actual treatment is to be developed. For this purpose the hyperthermia applicator is combined with an MRI system, which will allow to check the positioning of the patients and to measure individual blood perfusion as well as the 3D temperature distribution. The measurements will then be employed for an on-line control of the whole treatment. In this intended setting, new fast feedback control algorithms will come into play. T3 - ZIB-Report - 00-07 KW - hyperthermia KW - medical therapy planning KW - applicator design KW - interventional MRI Y1 - 2000 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-5755 ER - TY - GEN A1 - Deuflhard, Peter A1 - Louis, Alfred A1 - Schlegel, W. A1 - Seebass, Martin T1 - Workshop "Scientific Computing in der Medizin" SCMED '97 N2 - Die Arbeitstagung \glqq Scientific Computing in der Medizin\grqq , kurz SCMED \grq 97, findet vom 22. - 23. September 1997 im neu errichteten Gebäude des Konrad-Zuse-Zentrums auf dem Dahlemer naturwissenschaftlichen Campus der Freien Universtät Berlin statt. T3 - ZIB-Report - TR-97-05 Y1 - 1997 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-5474 ER - TY - GEN A1 - Seebass, Martin A1 - Beck, Rudolf A1 - Gellermann, Johanna A1 - Nadobny, Jacek A1 - Wust, Peter T1 - Electromagnetic phased arrays for regional hyperthermia -- optimal frequency and antenna arrangement N2 - In this paper we investigate the effects of the three-dimensional arrangement of antennas and frequency on temperature distributions that can be achieved in regional hyperthermia using an electromagnetic phased array. We compare the results of power-based and temperature-based optimization. Thus we are able to explain the discrepancies between previous studies favouring more antenna rings on the one hand and more antennas per ring on the other hand. We analyze the sensitivity of the results with respect to changes in amplitudes and phases as well as patient position. This analysis can be used for different purposes. First, it provides additional criteria for selecting the optimal frequency. Second, it can be used for specifying the required phase and amplitude accuracy for a real phased array system. Furthermore, it may serve as a basis for technological developments in order to reduce both types of sensitivities described above. T3 - ZIB-Report - 00-28 KW - Pelvic heating KW - phased array optimization Y1 - 2000 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-5961 ER - TY - GEN A1 - Erdmann, Bodo A1 - Lang, Jens A1 - Seebass, Martin T1 - Adaptive Solutions of Nonlinear Parabolic Equations with Application to Hyperthermia Treatments N2 - We present a self-adaptive finite element method to solve nonlinear evolution problems in 3D. An implicit time integrator of Rosenbrock type is coupled with a multilevel approach in space. The proposed method is applied to hyperthermia treatments to demonstrate its potential for the solving of complicated problems. T3 - ZIB-Report - SC-97-44 Y1 - 1997 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-3130 ER - TY - GEN A1 - Hege, Hans-Christian A1 - Seebass, Martin A1 - Stalling, Detlev A1 - Zöckler, Malte T1 - A Generalized Marching Cubes Algorithm Based on Non-Binary Classifications N2 - We present a new technique for generating surface meshes from a uniform set of discrete samples. Our method extends the well-known marching cubes algorithm used for computing polygonal isosurfaces. While in marching cubes each vertex of a cubic grid cell is binary classified as lying above or below an isosurface, in our approach an arbitrary number of vertex classes can be specified. Consequently the resulting surfaces consist of patches separating volumes of two different classes each. Similar to the marching cubes algorithm all grid cells are traversed and classified according to the number of different vertex classes involved and their arrangement. The solution for each configuration is computed based on a model that assigns probabilities to the vertices and interpolates them. We introduce an automatic method to find a triangulation which approximates the boundary surfaces - implicitly given by our model - in a topological correct way. Look-up tables guarantee a high performance of the algorithm. In medical applications our method can be used to extract surfaces from a 3D segmentation of tomographic images into multiple tissue types. The resulting surfaces are well suited for subsequent volumetric mesh generation, which is needed for simulation as well as visualization tasks. The proposed algorithm provides a robust and unique solution, avoiding ambiguities occuring in other methods. The method is of great significance in modeling and animation too, where it can be used for polygonalization of non-manifold implicit surfaces. T3 - ZIB-Report - SC-97-05 Y1 - 1997 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-2741 ER - TY - GEN A1 - Deuflhard, Peter A1 - Seebass, Martin T1 - Adaptive Multilevel FEM as Decisive Tools in the Clinical Cancer Therapy Hyperthermia N2 - The paper surveys recent progress in a joint mathematical-medical project on cancer therapy planning. Within so-called regional hyperthermia the computational task is to tune a set of coupled radiofrequency antennas such that a carefully measured tumor is locally heated, but any outside hot spots are avoided. A mathematical model of the whole clinical system -- air, applicator with antennas, water bolus, individual patient body -- involves Maxwell's equations in inhomogeneous media and a parabolic bioheat transfer equation, which represents a simplified model of heat transfer in the human body (ignoring strong blood vessel heat transport). Both PDEs need to be computed fast and to medical reliability (!) on a workstation within a clinical environment. This requirement triggered a series of new algorithmic developments to be reported here, among which is an adaptive multilevel FEM for Maxwell's equations, which dominates the numerical simulation time. In total, however, the main bulk of computation time (see Table 3 in Section 4 below) still goes into segmentation -- a necessary preprocessing step in the construction a 3D virtual patient from the input of a stack of 2D computed tomograms (left out here). T3 - ZIB-Report - SC-98-30 KW - hyperthermia KW - Maxwell's equations KW - nonlinear heat transfer KW - finite elements Y1 - 1998 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-3739 ER - TY - GEN A1 - Deuflhard, Peter A1 - Weiser, Martin A1 - Seebass, Martin T1 - A New Nonlinear Elliptic Multilevel FEM Applied to Regional Hyperthermia N2 - In the clinical cancer therapy of regional hyperthermia nonlinear perfusion effects inside and outside the tumor seem to play a not negligible role. A stationary model of such effects leads to a nonlinear Helmholtz term within an elliptic boundary value problem. The present paper reports about the application of a recently designed adaptive multilevel FEM to this problem. For several 3D virtual patients, nonlinear versus linear model is studied. Moreover, the numerical efficiency of the new algorithm is compared with a former application of an adaptive FEM to the corresponding instationary model PDE. T3 - ZIB-Report - SC-98-35 KW - hyperthermia KW - nonlinear elliptic KW - multilevel FEM Y1 - 1998 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-3785 ER - TY - GEN A1 - Seebass, Martin A1 - Sullivan, Dennis A1 - Wust, Peter A1 - Deuflhard, Peter A1 - Felix, Roland T1 - The Berlin Extension of the Stanford Hyperthermia Treatment. N2 - In the field of deep regional hyperthermia, one of the most widely used devices is the BSD--2000 Hyperthermia System which employs the Sigma 60 applicator. The Sigma 60 consists of four independent sources, giving it the potential to control the energy pattern within the patient. The independent amplitudes and phases, as well as frequency selection and applicator position, present a large number of parameters for the operator to determine. Computer simulation has long been recognized as an attractive approach to optimizing these parameters. A treatment planning program was used in clinical practice at Stanford University Medical Center for two years. It demonstrated the feasibility of computer simulation for deep regional hyperthermia in a clinical situation. However, several parts of this system were written in a language specific to one workstation, which severely restricted the wider distribution of the program to other users of the Sigma 60. A new treatment planning system for the BSD 2000 has been developed and put into clinical practice at the Rudolf Virchow Clinic of the Free University of Berlin. The new method, which we will refer to as the Berlin system, has a simpler model construction program and a considerably better graphics capability. However, the most important feature is that all programs are written in FORTRAN, C, or the X Window graphics system. Therefore, the entire treatment planning system is completely portable to other workstations. T3 - ZIB-Report - SC-93-35 Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-1304 ER - TY - GEN A1 - Beck, Rudolf A1 - Deuflhard, Peter A1 - Hege, Hans-Christian A1 - Seebass, Martin A1 - Stalling, Detlev T1 - Numerical Algorithms and Visualization in Medical Treament Planning N2 - After a short summary on therapy planning and the underlying technologies we discuss quantitative medicine by giving a short overview on medical image data, summarizing some applications of computer based treatment planning, and outlining requirements on medical planning systems. Then we continue with a description of our medical planning system {\sf HyperPlan}. It supports typical working steps in therapy planning, like data aquisition, segmentation, grid generation, numerical simulation and optimization, accompanying these with powerful visualization and interaction techniques. T3 - ZIB-Report - SC-96-54 Y1 - 1996 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-2643 ER - TY - GEN A1 - Deuflhard, Peter A1 - Seebass, Martin A1 - Stalling, Detlev A1 - Beck, Rudolf A1 - Hege, Hans-Christian T1 - Hyperthermia Treatment Planning in Clinical Cancer Therapy: Modelling, Simulation and Visualization N2 - \noindent The speaker and his co-workers in Scientific Computing and Visualization have established a close cooperation with medical doctors at the Rudolf--Virchow--Klinikum of the Humboldt University in Berlin on the topic of regional hyperthermia. In order to permit a patient--specific treatment planning, a special software system ({\sf\small HyperPlan}) has been developed. \noindent A mathematical model of the clinical system ({\it radio frequency applicator with 8 antennas, water bolus, individual patient body}) involves Maxwell's equations in inhomogeneous media and a so--called bio--heat transfer PDE describing the temperature distribution in the human body. The electromagnetic field and the thermal phenomena need to be computed at a speed suitable for the clinical environment. An individual geometric patient model is generated as a quite complicated tetrahedral ``coarse'' grid (several thousands of nodes). Both Maxwell's equations and the bio--heat transfer equation are solved on that 3D--grid by means of {\em adaptive} multilevel finite element methods, which automatically refine the grid where necessary in view of the required accuracy. Finally optimal antenna parameters for the applicator are determined . \noindent All steps of the planning process are supported by powerful visualization methods. Medical images, contours, grids, simulated electromagnetic fields and temperature distributions can be displayed in combination. A number of new algorithms and techniques had to be developed and implemented. Special emphasis has been put on advanced 3D interaction methods and user interface issues. T3 - ZIB-Report - SC-97-26 Y1 - 1997 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-2958 ER - TY - GEN A1 - Lang, Jens A1 - Erdmann, Bodo A1 - Seebass, Martin T1 - Impact of Nonlinear Heat Transfer on Temperature Control in Regional Hyperthermia N2 - We describe an optimization process specially designed for regional hyperthermia of deep seated tumors in order to achieve desired steady--state temperature distributions. A nonlinear three--dimensional heat transfer model based on temperature--dependent blood perfusion is applied to predict the temperature. Using linearly implicit methods in time and adaptive multilevel finite elements in space, we are able to integrate efficiently the instationary nonlinear heat equation with high accuracy. Optimal heating is obtained by minimizing an integral object function which measures the distance between desired and model predicted temperatures. A sequence of minima is calculated from successively improved constant--rate perfusion models employing a damped Newton method in an inner iteration. We compare temperature distributions for two individual patients calculated on coarse and fine spatial grids and present numerical results of optimizations for a Sigma 60 Applicator of the BSD 2000 Hyperthermia System. T3 - ZIB-Report - SC-97-73 Y1 - 1998 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-3426 ER - TY - GEN A1 - Erdmann, Bodo A1 - Lang, Jens A1 - Seebass, Martin T1 - Optimization of Temperature Distributions for Regional Hyperthermia Based on a Nonlinear Heat Transfer Model N2 - We describe an optimization process specially designed for regional hyperthermia of deap seated tumors in order to achieve desired steady--state temperature distributions. A nonlinear three--dimensional heat--transfer model based on temperature--dependent blood perfusion is applied to predict the temperature. Optimal heating is obtained by minimizing an integral object function which measures the distance between desired and model predicted temperatures. Sequential minima are calculated from successively improved constant--rate perfusion models employing a damped Newton method in an inner iteration. Numerical results for a Sigma 60 applicator are presented. This work has been supported by Deutsche Forschungsgemeinschaft (DFG) within the Sonderforschungsbereich 273 \glqq Hyperthermie: Methodik und Klinik \grqq . T3 - ZIB-Report - SC-97-59 Y1 - 1997 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-3283 ER - TY - CHAP A1 - Beck, Rudolf A1 - Deuflhard, Peter A1 - Hege, Hans-Christian A1 - Seebass, Martin A1 - Stalling, Detlev ED - Hege, Hans-Christian ED - Polthier, Konrad T1 - Numerical Algorithms and Visualization in Medical Treament Planning T2 - Visualization and Mathematics Y1 - 1997 SP - 303 EP - 328 PB - Springer-Verlag ER - TY - CHAP A1 - Beck, Rudolf A1 - Hege, Hans-Christian A1 - Seebass, Martin A1 - Wust, Peter A1 - Deuflhard, Peter A1 - Felix, Roland ED - Franconi, Cafiero T1 - Adaptive finite element codes for numerical calculations in hyperthermia treatment planning T2 - Proc. of the 7th Int. Congress on Hyperthermic Oncology, Rome, Italy, April 1996 Y1 - 1996 VL - 2 SP - 515 EP - 517 ER - TY - CHAP A1 - Nadobny, Johanna A1 - Sullivan, Dennis A1 - Wust, Peter A1 - Seebass, Martin A1 - Deuflhard, Peter A1 - Felix, Roland T1 - A High Resolution Interpretation at Arbitrary Interfaces for the FDTD Method T2 - IEEE Transactions on Microwave Theory and Techniques Y1 - 1998 VL - 46 IS - 11 SP - 1759 EP - 1766 ER - TY - CHAP A1 - Nadobny, Johanna A1 - Wust, Peter A1 - Seebass, Martin A1 - Deuflhard, Peter A1 - Felix, Roland ED - Simunic, D. T1 - The Use of the Volume-Surface Integral Equation Method (VSIE) for Antenna Problems T2 - Proc. COST 244 meeting on Reference Models for Bioelectromagnetic Test of Mobile Communication Systems, Roma, November 1994 Y1 - 1995 SP - 67 EP - 74 ER - TY - JOUR A1 - Nadobny, Johanna A1 - Wust, Peter A1 - Seebass, Martin A1 - Deuflhard, Peter A1 - Felix, Roland T1 - A Volume-Surface Integral Method for Solving Maxwell’s Equations in Electrically Inhomogeneous Media Using Tetrahedral Grids JF - IEEE Transactions on Microwave Theory and Techniques Y1 - 1996 VL - 44 IS - 4 SP - 543 EP - 554 ER - TY - CHAP A1 - Nadobny, Johanna A1 - Wust, Peter A1 - Seebass, Martin A1 - Stalling, Detlev A1 - Hege, Hans-Christian A1 - Deuflhard, Peter A1 - Felix, Roland T1 - A Quantitative Comparison between the VSIE and the FDTD method using Electrically Equivalent Patient and Antenna Models T2 - Proc. 16th Ann. Meeting Europ. Soc. Hyperthermic Oncology (ESHO-97), Berlin, Germany, April 1997 Y1 - 1997 SP - 145 ER - TY - CHAP A1 - Nadobny, Johanna A1 - Wust, Peter A1 - Wlodarczyk, Waldemar A1 - Seebass, Martin A1 - Deuflhard, Peter A1 - Felix, Roland ED - Franconi, Cafiero T1 - Simulation Studies for Combination of Hyperthermia and Magnetic Resonance Systems T2 - Proc. of the 7th Int. Congress on Hyperthermic Oncology, Rome, Italy, April 1996 Y1 - 1996 VL - 2 SP - 549 EP - 551 ER - TY - CHAP A1 - Deuflhard, Peter A1 - Hege, Hans-Christian A1 - Seebass, Martin ED - Grönemeyer, W. T1 - Progress Towards a Combined MRI Hyperthermia System T2 - Proc. Second Int. Congress HIGH CARE 2000, Bochum Y1 - 2000 ER - TY - JOUR A1 - Gellermann, Johanna A1 - Wust, Peter A1 - Stalling, Detlev A1 - Seebass, Martin A1 - Nadobny, Johanna A1 - Beck, Rudolf A1 - Hege, Hans-Christian A1 - Deuflhard, Peter A1 - Felix, Roland T1 - Clinical evaluation and verification of the hyperthermia treatment planning system hyperplan JF - Int J Radiat Oncol Biol Phys Y1 - 2000 VL - 47 IS - 4 SP - 1145 EP - 1156 ER - TY - CHAP A1 - Deuflhard, Peter A1 - Seebass, Martin ED - Lai, Choi-Hong ED - Bjørstad, Petter E. ED - Cross, Mark ED - Widlund, Olof T1 - Adaptive Multilevel FEM as Decisive Tools in the Clinical Cancer Therapy Hyperthermia T2 - Procs. Eleventh International Conference on Domain Decomposition Methods Y1 - 1999 SP - 403 EP - 414 PB - DDM-org Press,Bergen ER - TY - CHAP A1 - Deuflhard, Peter A1 - Seebass, Martin A1 - Stalling, Detlev A1 - Beck, Rudolf A1 - Hege, Hans-Christian ED - Sydow, Achim T1 - Hyperthermia Treatment Planning in Clinical Cancer Therapy:Modelling, Simulation, and Visualization T2 - Computational Physics, Chemistry and Biology Y1 - 1997 VL - 3 PB - Wissenschaft und Technik Verlag CY - Plenary keynote talk, 15th IMACS World Congress 1997 on Scientific Computation, Modelling and Applied Mathematics ER - TY - CHAP A1 - Erdmann, Bodo A1 - Lang, Jens A1 - Seebass, Martin ED - de Vahl Davis, G. ED - Leonardi, E. T1 - Adaptive Solutions of Nonlinear Parabolic Equations with Application to Hyperthermia Treatments T2 - CHT’97 Y1 - 1997 SP - 103 EP - 110 CY - Cesme, Turkey ER - TY - CHAP A1 - Erdmann, Bodo A1 - Lang, Jens A1 - Seebass, Martin ED - Diller, K. T1 - Optimization of Temperature Distributions for Regional Hyperthermia based on a Nonlinear Heat Transfer Model T2 - Biotransport Y1 - 1998 VL - 858 SP - 36 EP - 46 ER - TY - JOUR A1 - Erdmann, Bodo A1 - Lang, Jens A1 - Seebass, Martin T1 - The Impact of a Nonlinear Heat Transfer Model for Temperature Control in Regional Hyperthermia JF - IEEE Transactions on Biomedical Engineering Y1 - 1999 VL - 49 IS - 9 SP - 1129 EP - 1138 ER - TY - CHAP A1 - Gellermann, Johanna A1 - Wust, Peter A1 - Stalling, Detlev A1 - Tilly, Wolfgang A1 - Nadobny, Johanna A1 - Seebass, Martin A1 - Deuflhard, Peter A1 - Felix, Roland A1 - Budach, Volker T1 - First Clinical Experiences with the Hyperthermia Planning System HyperPlan T2 - Proc. 16th Ann. Meeting Europ. Soc. Hyperthermic Oncology (ESHO-97), Berlin, Germany, April 1997 Y1 - 1997 SP - 79 ER - TY - JOUR A1 - Deuflhard, Peter A1 - Weiser, Martin A1 - Seebass, Martin T1 - A new nonlinear elliptic multilevel FEM in clinical cancer therapy planning JF - Comput. Vis. Sci. Y1 - 2000 VL - 3 SP - 115 EP - 120 ER - TY - CHAP A1 - Lamecker, Hans A1 - Seebaß, Martin A1 - Hege, Hans-Christian A1 - Deuflhard, Peter ED - Fitzpatrick, J. ED - Sonka, Milan T1 - A 3d statistical shape model of the pelvic bone for segmentation T2 - Proc. SPIE Medical Imaging 2004 Y1 - 2004 VL - 5370 SP - 1341 EP - 1351 ER - TY - CHAP A1 - Lamecker, Hans A1 - Seebass, Martin A1 - Lange, Thomas A1 - Hege, Hans-Christian A1 - Deuflhard, Peter ED - Westwood, J. T1 - Visualization of the variability of 3D statistical shape models by animation T2 - Proc. Medicine Meets Virtual Reality Y1 - 2004 VL - 98 SP - 190 EP - 196 PB - IOS Press ER - TY - CHAP A1 - Lange, Thomas A1 - Wenckebach, Thomas A1 - Lamecke, Hans A1 - Seebaß, Martin A1 - Hünerbein, Michael A1 - Eulenstein, Sebastian A1 - Schlag, Peter-Michael ED - Lemke, Heinz T1 - Registration of portal and hepatic venous phase of MR/CT data for computer-assisted liver surgery planning T2 - Proc. Computer Assisted Radiology and Surgery (CARS) Y1 - 2005 U6 - https://doi.org/10.1016/j.ics.2005.03.332 SP - 768 EP - 772 PB - Elsevier ER - TY - CHAP A1 - Lange, Thomas A1 - Wenckebach, Thomas A1 - Lamecker, Hans A1 - Seebaß, Martin A1 - Hünerbein, Michael A1 - Eulenstein, Sebastian A1 - Schlag, Peter-Michael T1 - Registration of different phases of contrast-enhanced CT/MRI data for computer-assisted liver surgery planning T2 - Int. J. Medical Robotics and Computer Assisted Surgery Y1 - 2005 U6 - https://doi.org/10.1002/rcs.23 VL - 1 (3) SP - 6 EP - 20 PB - Wiley ER - TY - CHAP A1 - Seebaß, Martin A1 - Lamecker, Hans A1 - Lange, Thomas A1 - Gellermann, Johanna A1 - Wust, Peter T1 - A Statistical Shape Model of the Pelvic Bone for Segmentation T2 - European Society for Hyperthermic Oncology Annual Meeting Proceedings Y1 - 2003 SP - 91 EP - 92 ER - TY - CHAP A1 - Lange, Thomas A1 - Wenckebach, Thomas A1 - Seebaß, Martin A1 - Lamecker, Hans A1 - Hünerbein, Michael T1 - Registration of different phases of contrast-enhanced MR data for liver surgery T2 - 3. Jahrestagung der Deutschen Gesellschaft für Computer-Roboterassistierte Chirurgie CURAC Y1 - 2004 ER - TY - CHAP A1 - Seebaß, Martin A1 - Lamecker, Hans A1 - Gellermann, Johanna A1 - Wust, Peter T1 - The impact of segmentation accuracy on treatment planning for regional hyperthermia T2 - Proceedings of the 9th International Congress on Hyperthermic Oncology Y1 - 2004 ER - TY - CHAP A1 - Lamecker, Hans A1 - Seebaß, Martin A1 - Hege, Hans-Christian A1 - Deuflhard, Peter ED - Fitzpatrick, J. ED - Sonka, Milan T1 - A 3D statistical shape model of the pelvic bone for segmentation T2 - Proceedings of SPIE - Volume 5370 Medical Imaging 2004 Y1 - 2004 U6 - https://doi.org/10.1117/12.534145 SP - 1341 EP - 1351 ER - TY - CHAP A1 - Lamecker, Hans A1 - Lange, Thomas A1 - Seebaß, Martin A1 - Eulenstein, Sebastian A1 - Westerhoff, Malte A1 - Hege, Hans-Christian T1 - Automatic Segmentation of the Liver for Preoperative Planning of Resections T2 - Proc. MMVR 2003 Y1 - 2003 SP - 171 EP - 173 PB - IOS press CY - Newport Beach, CA ER - TY - CHAP A1 - Lamecker, Hans A1 - Lange, Thomas A1 - Seebaß, Martin T1 - A Statistical Shape Model for the Liver T2 - MICCAI 2002 Y1 - 2002 U6 - https://doi.org/10.1007/3-540-45787-9_53 SP - 422 EP - 427 PB - Springer ER - TY - CHAP A1 - Lamecker, Hans A1 - Lange, Thomas A1 - Seebaß, Martin T1 - Erzeugung statistischer 3D-Formmodelle zur Segmentierung medizinischer Bilddaten T2 - Proc. BVM 2003 Y1 - 2003 SP - 398 EP - 403 PB - Springer CY - Erlangen ER - TY - CHAP A1 - Lange, Thomas A1 - Lamecker, Hans A1 - Seebaß, Martin T1 - Ein Softwarepaket für die modellbasierte Segmentierung anatomischer Strukturen T2 - Proc. BVM 2003 Y1 - 2003 SP - 111 EP - 116 CY - Erlangen ER - TY - JOUR A1 - Deuflhard, Peter A1 - Weiser, Martin A1 - Seebaß, Martin T1 - A New Nonlinear Elliptic Multilevel FEM Applied to Regional Hyperthermia JF - Comput. Visual. Sci. Y1 - 2000 U6 - https://doi.org/10.1007/PL00013546 VL - 3 SP - 1 EP - 6 ER - TY - JOUR A1 - Gellermann, Johanna A1 - Wust, Peter A1 - Stalling, Detlev A1 - Seebaß, Martin A1 - Nadobny, Jacek A1 - Hege, Hans-Christian A1 - Deuflhard, Peter A1 - Felix, Roland T1 - Clinical evaluation and verification of the hyperthermia treatment planning system HyperPlan JF - Int. J. Radiat. Oncol. Biol. Phys. Y1 - 2000 U6 - https://doi.org/10.1016/S0360-3016(00)00425-9 VL - 47(4) SP - 1145 EP - 1156 ER - TY - JOUR A1 - Seebaß, Martin A1 - Beck, Rudolf A1 - Gellermann, Johanna A1 - Nadobny, Jacek A1 - Wust, Peter T1 - Electromagnetic Phased Arrays for Regional Hyperthermia - Optimal Frequency and Antenna Arrangement JF - Int. J. Hyperthermia Y1 - 2000 VL - 17(4) SP - 321 EP - 326 ER - TY - JOUR A1 - Wust, Peter A1 - Beck, Rudolf A1 - Berger, Jörn A1 - Fähling, Horst A1 - Seebaß, Martin A1 - Wlodarczyk, Waldemar A1 - Hoffmann, Werner A1 - Nadobny, Jacek T1 - Electric Field Distributions in a Phased-Array Applicator with 12 Channels - Measurements and Numerical Simulations JF - Medical Physics Y1 - 2000 VL - 27 SP - 2565 EP - 2579 ER - TY - CHAP A1 - Beck, Rudolf A1 - Deuflhard, Peter A1 - Hege, Hans-Christian A1 - Seebaß, Martin A1 - Stalling, Detlev ED - Hege, Hans-Christian ED - Polthier, Konrad T1 - Numerical Algorithms and Visualization in Medical Treatment Planning T2 - Visualization and Mathematics 1997 Y1 - 1996 SP - 303 EP - 328 PB - Springer, Heidelberg ER - TY - CHAP A1 - Beck, Rudolf A1 - Hege, Hans-Christian A1 - Seebaß, Martin A1 - Wust, Peter A1 - Deuflhard, Peter A1 - Felix, Roland T1 - Adaptive Finite Element Codes for Numerical Calculations in Hyperthermia Treatment Planning T2 - Proceedings of the 17th Congress on Hyperthermic Oncology Y1 - 1996 VL - 2 SP - 515 EP - 517 CY - Rome, Italy ER - TY - JOUR A1 - Nadobny, Jacek A1 - Wust, Peter A1 - Seebaß, Martin A1 - Deuflhard, Peter A1 - Felix, Roland T1 - A Volume Surface Integral Equation Method for Solving Maxwell’s Equations in Electrically Inhomogeneous Media Using Tetrahedral Grids JF - IEEE Transactions Microwave Theory Techn. Y1 - 1996 U6 - https://doi.org/10.1109/22.491022 VL - 44 IS - 4 SP - 543 EP - 554 ER - TY - CHAP A1 - Deuflhard, Peter A1 - Hege, Hans-Christian A1 - Seebaß, Martin T1 - Progress Towards a Combined MRI/Hyperthermia System T2 - Proceedings Second International Congress HIGH CARE 2000 Y1 - 2000 CY - Bochum ER - TY - JOUR A1 - Wust, Peter A1 - Nadobny, Jacek A1 - Seebaß, Martin A1 - Stalling, Detlev A1 - Gellermann, Johanna A1 - Hege, Hans-Christian A1 - Deuflhard, Peter T1 - Influence of Patient Models and Numerical Methods on Predicted Power Deposition Patterns JF - Int. Journal Hyperthermia Y1 - 1999 VL - 15 IS - 6 SP - 519 EP - 540 ER - TY - CHAP A1 - Stalling, Detlev A1 - Seebaß, Martin A1 - Zachow, Stefan T1 - Mehrschichtige Oberflächenmodelle zur computergestützten Planung in der Chirurgie T2 - Bildverarbeitung für die Medizin 1999 - Algorithmen, Anwendungen Y1 - 1999 SP - 203 EP - 207 PB - Springer-Verlag, Berlin ER - TY - CHAP A1 - Seebaß, Martin A1 - Stalling, Detlev A1 - Hege, Hans-Christian A1 - Wust, Peter A1 - Felix, Roland A1 - Deuflhard, Peter T1 - New Features of HyperPlan, a Hyperthermia Planning System T2 - Proc. Hyperthermia in Clincal Oncology Y1 - 1998 SP - 16 CY - Venice ER - TY - CHAP A1 - Seebaß, Martin A1 - Stalling, Detlev A1 - Zöckler, Malte A1 - Hege, Hans-Christian A1 - Wust, Peter A1 - Felix, Roland A1 - Deuflhard, Peter T1 - Surface Mesh Generation for Numerical Simulations of Hyperthermia Treatments T2 - Proceedings of the 16th Annual Meeting of the European Society for Hyperthermic Oncology (ESHO-97) Y1 - 1997 SP - 146 ER - TY - CHAP A1 - Deuflhard, Peter A1 - Seebaß, Martin A1 - Stalling, Detlev A1 - Beck, Rudolf A1 - Hege, Hans-Christian ED - Sydow, Achim T1 - Hyperthermia Treatment Planning in Clinical Therapy T2 - Computational Physics, Chemistry and Biology (Proceedings of the 15th IMACS World Congress 1997 on Scientific Computation 3, Modelling and Applied Mathematics) Y1 - 1997 SP - 9 EP - 17 PB - Wissenschaft und Technik Verlag ER - TY - CHAP A1 - Wust, Peter A1 - Nadobny, Jacek A1 - Gellermann, Johanna A1 - Seebaß, Martin A1 - Stalling, Detlev A1 - Hege, Hans-Christian A1 - Deuflhard, Peter A1 - Felix, Roland T1 - Patient Models and Algorithms for Hyperthermia Planning T2 - Proceedings of the 16th Annual Meeting of the European Society for Hyperthermic Oncology ESHO-97 Y1 - 1997 ER - TY - JOUR A1 - Nadobny, Jacek A1 - Sullivan, Dennis A1 - Wust, Peter A1 - Seebaß, Martin A1 - Deuflhard, Peter A1 - Felix, Roland T1 - A High-Resolution Interpolation at Arbitary Interfaces for the FDTD Method JF - IEEE Trans. Microwave Theory Tech. Y1 - 1998 U6 - https://doi.org/10.1109/22.734576 VL - 46 IS - 11 SP - 1759 EP - 1766 ER - TY - CHAP A1 - Nadobny, Jacek A1 - Wust, Peter A1 - Fähling, Horst A1 - Stalling, Detlev A1 - Seebaß, Martin A1 - Deuflhard, Peter A1 - Felix, Roland T1 - Numerical and Experimental Evaluation of E-Field and Absorbed Power in the Pelvic Region Using a Bone-Equivalent Phantom T2 - Proc. PIERS Progress in Electromagnetic Research Symposium Y1 - 1998 SP - 264 CY - Nantes ER - TY - JOUR A1 - Lang, Jens A1 - Erdmann, Bodo A1 - Seebaß, Martin T1 - Impact of Nonlinear Heat Tansfer on Temperature Control in Regional Hypertermia JF - IEEE Trans. Biomed. Engrg. Y1 - 1999 U6 - https://doi.org/10.1109/10.784145 VL - 46 SP - 1129 EP - 1138 ER - TY - JOUR A1 - Seebaß, Martin A1 - Wust, Peter A1 - Gellermann, Johanna A1 - Stalling, Detlev A1 - Nadobny, Jacek A1 - Felix, Roland T1 - Dreidimensionale Simulation der nicht-invasiven Radiowellen-Hyperthermie JF - Minimal Invasive Medizin Y1 - 1995 VL - 6 IS - 1 SP - 29 EP - 35 ER - TY - CHAP A1 - Nadobny, Jacek A1 - Wust, Peter A1 - Wlodarczyk, Waldemar A1 - Seebaß, Martin A1 - Deuflhard, Peter A1 - Mönich, Gerhard A1 - Felix, Roland T1 - Simulation Studies for Combination of Hyperthermia and Magnetic Resonance Systems T2 - Proceedings of the 17th Congress on Hyperthermic Oncology Y1 - 1996 VL - 2 SP - 549 EP - 551 CY - Rome, Italy ER - TY - CHAP A1 - Seebaß, Martin A1 - Stalling, Detlev A1 - Nadobny, Jacek A1 - Wust, Peter A1 - Felix, Roland A1 - Deuflhard, Peter T1 - Three-Dimensional Finite Elements Mesh Generation for Numerical Simulations of Hyperthermia Treatments T2 - Proceedings of the 17th Congress on Hyperthermic Oncology Y1 - 1996 VL - 2 SP - 547 EP - 548 CY - Rome, Italy ER - TY - CHAP A1 - Stalling, Detlev A1 - Seebaß, Martin A1 - Hege, Hans-Christian A1 - Wust, Peter A1 - Deuflhard, Peter A1 - Felix, Roland T1 - HyperPlan - an Integrated System for Treatment Planning in Regional Hyperthermia T2 - Proceedings of the 17th Congress on Hyperthermic Oncology Y1 - 1996 VL - 2 SP - 552 EP - 554 CY - Rome, Italy ER - TY - JOUR A1 - Wust, Peter A1 - Seebaß, Martin A1 - Nadobny, Jacek A1 - Deuflhard, Peter A1 - Mönich, Gerhard A1 - Felix, Roland T1 - Simulation Studies Promote Technological Development of Radiofrequency Phased Array Hyperthermia JF - Int. Journal of Hyperthermia Y1 - 1996 VL - 12 SP - 477 EP - 494 ER - TY - JOUR A1 - Wust, Peter A1 - Nadobny, Johanna A1 - Seebass, Martin A1 - Stalling, Detlev A1 - Gellermann, Johanna A1 - Hege, Hans-Christian A1 - Deuflhard, Peter A1 - Felix, Roland T1 - Influence of patient models and numerical methods on predicted power deposition patterns JF - Int. J. Hyperthermia Y1 - 1999 VL - 15 IS - 6 SP - 519 EP - 540 ER - TY - JOUR A1 - Wust, Peter A1 - Seebass, Martin A1 - Nadobny, Johanna A1 - Deuflhard, Peter A1 - Mönich, Gerhard A1 - Felix, Roland T1 - Simulation studies promote technological development of radiofrequency phased array hyperthermia JF - Int J Hyperthermia Y1 - 1996 VL - 12 IS - 4 SP - 477 EP - 494 ER - TY - CHAP A1 - Seebass, Martin A1 - Stalling, Detlev A1 - Nadobny, Johanna A1 - Wust, Peter A1 - Felix, Roland A1 - Deuflhard, Peter ED - Franconi, Cafiero T1 - Three-Dimensional Finite Element Mesh Generation for Numerical Simulations of Hyperthermia Treatments T2 - Proc. of the 7th Int. Congress on Hyperthermic Oncology, Rome, Italy, April 1996 Y1 - 1996 VL - 2 SP - 547 EP - 548 ER - TY - CHAP A1 - Seebass, Martin A1 - Stalling, Detlev A1 - Zöckler, M. A1 - Hege, Hans-Christian A1 - Wust, Peter A1 - Felix, Roland A1 - Deuflhard, Peter T1 - Surface Mesh Generation for Numerical Simulations of Hyperthermia Treatments T2 - Proc. 16th Ann. Meeting Europ. Soc. Hyperthermic Oncology (ESHO-97), Berlin, Germany, April 1997 Y1 - 1997 SP - 146 ER - TY - JOUR A1 - Wust, Peter A1 - Fahling, Horst A1 - Wlodarczyk, Waldemar A1 - Seebass, Martin A1 - Gellermann, Johanna A1 - Deuflhard, Peter A1 - Nadobny, Johanna T1 - Antenna arrays in the SIGMA-eye applicator JF - Med Phys Y1 - 2001 VL - 28 IS - 8 SP - 1793 EP - 1805 ER - TY - CHAP A1 - Wust, Peter A1 - Nadobny, Johanna A1 - Gellermann, Johanna A1 - Seebass, Martin A1 - Stalling, Detlev A1 - Hege, Hans-Christian A1 - Deuflhard, Peter A1 - Budach, Volker A1 - Felix, Roland T1 - Patient Models and Algorithms for Hyperthermia Planning T2 - Proc. 16th Ann. Meeting Europ. Soc. Hyperthermic Oncology (ESHO-97), Berlin, Germany, April 1997 Y1 - 1997 SP - 75 ER - TY - CHAP A1 - Stalling, Detlev A1 - Seebass, Martin A1 - Hege, Hans-Christian A1 - Wust, Peter A1 - Deuflhard, Peter A1 - Felix, Roland ED - Franconi, Cafiero T1 - HyperPlan - an integrated system for treatment planning in regional hyperthermia T2 - Proc. of the 7th Int. Congress on Hyperthermic Oncology, Rome, Italy, April 1996 Y1 - 1996 VL - 2 SP - 552 EP - 554 ER - TY - GEN A1 - Stalling, Detlev A1 - Seebass, Martin A1 - Zachow, Stefan T1 - Mehrschichtige Oberflächenmodelle zur computergestützten Planung in der Chirurgie N2 - Polygonale Schädelmodelle bilden ein wichtiges Hilfsmittel für computergestützte Planungen im Bereich der plastischen Chirurgie. Wir beschreiben, wie derartige Modelle automatisch aus hochaufgelösten CT-Datensätzen erzeugt werden können. Durch einen lokal steuerbaren Simplifizierungsalgorithmus werden die Modelle so weit vereinfacht, daß auch auf kleineren Graphikcomputern interaktives Arbeiten möglich wird. Die Verwendung eines speziellen Transparenzmodells ermöglicht den ungehinderten Blick auf die bei der Planung relevanten Knochenstrukturen und läßt den Benutzer zugleich die Kopfumrisse des Patienten erkennen. T3 - ZIB-Report - TR-98-05 KW - Isoflächen KW - Simplifizierung KW - Transparenzen Y1 - 1998 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-5661 ER - TY - GEN A1 - Lamecker, Hans A1 - Lange, Thomas A1 - Seebass, Martin T1 - Segmentation of the Liver using a 3D Statistical Shape Model N2 - This paper presents an automatic approach for segmentation of the liver from computer tomography (CT) images based on a 3D statistical shape model. Segmentation of the liver is an important prerequisite in liver surgery planning. One of the major challenges in building a 3D shape model from a training set of segmented instances of an object is the determination of the correspondence between different surfaces. We propose to use a geometric approach that is based on minimizing the distortion of the correspondence mapping between two different surfaces. For the adaption of the shape model to the image data a profile model based on the grey value appearance of the liver and its surrounding tissues in contrast enhanced CT data was developed. The robustness of this method results from a previous nonlinear diffusion filtering of the image data. Special focus is turned to the quantitative evaluation of the segmentation process. Several different error measures are discussed and implemented in a study involving more than 30 livers. T3 - ZIB-Report - 04-09 KW - Statistical Shape Model KW - 3D Correspondence Problem KW - Model-Based Segmentation KW - Diffusion Filtering KW - Geometric Distortion KW - Surface Distance Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-7847 ER - TY - GEN A1 - Stalling, Detlev A1 - Seebass, Martin A1 - Zöckler, Malte A1 - Hege, Hans-Christian T1 - Hyperthermia Treatment Planning with HyperPlan - User's Manual N2 - HyperPlan is a software system for performing 3D-simulations and treatment planning in regional hyperthermia. It allows the user to understand the complex effects of electromagnetic wave propagation and heat transport inside a patient's body. Optimized power amplitudes and phase settings can be calculated for the BSD radiowave applicators Sigma 60 and Sigma 2000 (eye-applicator). HyperPlan is built on top of the modular, object-oriented visualization system Amira. This system already contains powerful algorithms for image processing, geometric modelling and 3D graphics display. HyperPlan provides a number of hyperthermia-specific modules, allowing the user to create 3D tetrahedral patient models suitable for treatment planning. In addition, all numerical simulation modules required for hyperthermia simulation are part of HyperPlan. This guide provides a step-by-step introduction to hyperthermia planning using HyperPlan. It also describes the usage of the underlying visualization system Amira. T3 - ZIB-Report - 00-27 KW - image segmentation KW - grid generation KW - visualization KW - therapy planning Y1 - 2000 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:0297-zib-5957 ER - TY - CHAP A1 - Deuflhard, Peter A1 - Seebaß, Martin ED - Lai, Choi-Hong ED - Bjorstad, Petter ED - Cross, Mark ED - Widlund, Olof T1 - Adaptive Multilevel FEM as Decisive Tools in the Clinical Cancer Therapy Hyerthermia T2 - Proc. Eleventh International Conference on Domain Decomposition Methods in Sciences and Engineering Y1 - 1998 SP - 410 EP - 421 CY - Greenwich, UK ER -